Michelle D Walker

US Patent:

7217704, May 15, 2007

Filed:

Oct 12, 2004

Appl. No.:

10/963085

Inventors:

Duane D. Miller - Germantown TN, US
Gabor Tigyi - Memphis TN, US
Gangadhar G. Durgam - Memphis TN, US
Tamas Virag - Chicago IL, US
Michelle D. Walker - Memphis TN, US
Ryoko Tsukahara - Memphis TN, US

Assignee:

The University of Tennessee Research Foundation - Knoxville TN

International Classification:

A61K 31/6615
C07F 9/165
C07D 233/56
C07D 233/20
A61K 31/675

US Classification:

514144, 558213, 514 94, 514119, 5483421, 5483511

Abstract:

The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.

US Patent:

7947665, May 24, 2011

Filed:

May 14, 2007

Appl. No.:

11/748331

Inventors:

Duane D. Miller - Germantown TN, US
Gabor Tigyi - Memphis TN, US
Gangadhar G. Durgam - Memphis TN, US
Tamas Virag - Chicago IL, US
Michelle D. Walker - Memphis TN, US
Ryoko Tsukahara - Memphis TN, US

International Classification:

A61K 31/675

US Classification:

514 94, 514114, 514119, 514120, 514143

Abstract:

Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.

US Patent:

20060270634, Nov 30, 2006

Filed:

May 6, 2006

Appl. No.:

11/418561

Inventors:

Duane Miller - Memphis TN, US
Gabor Tigyi - Memphis TN, US
Yuko Fujiwara - Memphis TN, US
Daniel Baker - Memphis TN, US
Michelle Walker - Alexandria VA, US
Gangadar Durgam - Memphis TN, US

International Classification:

A61K 31/665

US Classification:

514099000, 549216000

Abstract:

Disclosed are compositions that modulate the effects of extracellular LPA receptors, the intracellular PPARγ receptor, and autotaxin, and methods for their use.

US Patent:

20120135967, May 31, 2012

Filed:

May 23, 2011

Appl. No.:

13/114010

Inventors:

Duane D. Miller - Germantown TN, US
Gabor Tigyi - Memphis TN, US
Gangadhar G. Durgam - Memphis TN, US
Tamas Virag - Chicago IL, US
Michelle D. Walker - Memphis TN, US
Ryoko Tsukahara - Memphis TN, US

International Classification:

A61K 31/661
A61P 1/12

US Classification:

514134, 514143

Abstract:

Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.