Michelle Lee Young

US Patent:

6797713, Sep 28, 2004

Filed:

Sep 12, 2002

Appl. No.:

10/242346

Inventors:

Ralph Scannell - Hopkinson MA
Pierre Chatelain - Woluwe Saint Pierre, BE
Anna Toy-Palmer - Arlington MA
Edmond Differding - Louvain-la-Neuve, BE
James Ellis - Boxford MA
Marie-Agnes Lassoie - Braine-le-Chateau, BE
Michelle Young - Belmont MA
Xiong Cai - Belmont MA
Sajjat Hussoin - Lexington MA
Gurmit Grewal - Natick MA
Timothy Lewis - Marlborough MA

Assignee:

UCB S.A. - Brussels

International Classification:

A61K 31495

US Classification:

51425504, 544396

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

6894059, May 17, 2005

Filed:

Mar 23, 2000

Appl. No.:

09/937667

Inventors:

Ralph Scannell - Hopkinson MA, US
Pierre Chatelain - Woluwe Saint Pierre, BE
Anna Toy-Palmer - Arlington MA, US
Edmund Differding - Louvain-La-Neuve, BE
James Ellis - Boxford MA, US
Marie-Agnes Lassoie - Braine-Le-Chateau, BE
Michelle Young - Belmont MA, US
Xiong Cai - Belmont MA, US
Sajjat Hussoin - Lexington MA, US
Gurmit Grewal - Natick MA, US
Timothy Lewis - Framingham MA, US

Assignee:

UCB S.A. - Brussels

International Classification:

A61K031/44
A61K031/445

US Classification:

514290, 514325, 514329, 514330, 514331, 514340, 546 93, 546192, 546226, 546229, 5462681

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obsructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.

US Patent:

20030055084, Mar 20, 2003

Filed:

Jul 30, 2002

Appl. No.:

10/209188

Inventors:

Gurmit Grewal - Natick MA, US
Ralph Scannell - Hopkinton MA, US
Xiong Cai - Belmont MA, US
Michelle Young - Belmont MA, US
Aberra Fura - Lawerenceville NJ, US

Assignee:

Millennium Pharmaceutical, Inc.

International Classification:

A61K031/453
A61K031/451
A61K031/4025
A61K031/381
A61K031/343
C 07D 4 9/02
C 07D 4 5/02

US Classification:

514/320000, 514/422000, 514/438000, 514/443000, 514/444000, 514/469000, 546/202000, 546/196000, 548/525000, 549/049000, 549/060000, 549/462000

Abstract:

The present invention provides substituted benzofuran, indene, thianaphthene and oxidized thianaphthene compounds and methods of treatment and pharmaceutical compositions that comprise such compounds. Preferred compounds of the invention contain benzofuran, indene or thianaphthene group substituted with a tetrahydrofuran or other alicyclic group.

US Patent:

20040048875, Mar 11, 2004

Filed:

Aug 8, 2003

Appl. No.:

10/637163

Inventors:

Ralph Scannell - Hopkinson MA, US
Pierre Chatelain - Woluwe Saint Pierre, BE
Anna Toy-Palmer - Arlington MA, US
Edmond Differding - Louvain-La-Neuve, BE
James Ellis - Boxford MA, US
Marie-Agnes Lassoie - Braine-Le-Chateau, BE
Michelle Young - Belmont MA, US
Xiong Cai - Belmont MA, US
Sajjat Hussoin - Lexington MA, US
Gurmit Grewal - Natick MA, US
Timothy Lewis - Marlborough MA, US

Assignee:

UCB S.A.

International Classification:

A61K031/496
A61K031/495
A61K031/473
A61K031/4545

US Classification:

514/253010, 514/253030, 514/255040, 514/290000, 514/317000, 514/316000, 544/360000, 544/361000, 546/093000

Abstract:

The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted,4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting molecules having both leukotriene inhibition properties as well as antihistaminergic properties. The compounds of the invention are useful for treating conditions in which there is likely to be a histamine and/or leukotriene component. These conditions include preferably asthma, seasonal and perennial allergic rhinitis, sinusitus, conjunctivitis, food allergy, scombroid poisoning, psoriasis, urticaria, pruritus, eczema, rheumatoid arthritis, inflammatory bowel disease, chronic obstructive pulmonary disease, thrombotic disease and otitis media. Also provided are methods of treating asthma and rhinitis by administering an effective asthma and rhinitis-relieving amount of the compounds to a subject in need thereof.