Mikhail R Shapiro

US Patent:

20110212163, Sep 1, 2011

Filed:

Jul 23, 2009

Appl. No.:

13/055195

Inventors:

Todd R. Hoare - Ontario, CA
Daniel S. Kohane - Newton MA, US
Robert S. Langer - Newton MA, US
Mikhail G. Shapiro - Boston MA, US
Yoon Yeo - Cambridge MA, US
Grace Y. Kim - Cambridge MA, US

Assignee:

CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
THE GENERAL HOSPITAL CORPORATION D/B/A - Boston MA

International Classification:

A61K 47/02
A61K 9/127

US Classification:

424450, 514769

Abstract:

The present invention generally relates to systems and methods for releasing a compound from an article using an external trigger, for example, magnetic fields. One aspect of the invention is generally directed to an article containing a magnetically-susceptible material. Exposure of the magnetically-susceptible material to a magnetic field, such as an oscillating magnetic field, may cause the magnetically-susceptible material to increase in temperature. This increase in temperature may be used, in some embodiments, to cause the release of a drug or other releasable material from the article. For instance, the drug may be contained in a heat-sensitive material in thermal communication with the magnetically-susceptible material, or the drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material in thermal communication with the magnetically-susceptible material. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, or the like.

US Patent:

20120208706, Aug 16, 2012

Filed:

Dec 29, 2011

Appl. No.:

13/339986

Inventors:

Sean R. Downing - Methuen MA, US
Mirna Jarosz - Arlington MA, US
Doron Lipson - Chestnut Hill MA, US
Geoffrey Alan Otto - Brookline MA, US
Alexander N. Parker - West Roxbury MA, US
Mikhail G. Shapiro - San Francisco CA, US
Philip James Stephens - Lexington MA, US
Roman Yelensky - Newton MA, US

Assignee:

FOUNDATION MEDICINE, INC. - Cambridge MA

International Classification:

C40B 20/00
C40B 40/06
C40B 50/00
C40B 30/04

US Classification:

506 2, 506 9, 506 16, 506 23

Abstract:

A method of analyzing a tumor sample comprising:

US Patent:

20110135575, Jun 9, 2011

Filed:

Aug 28, 2008

Appl. No.:

12/675256

Inventors:

Mikhail G. Shapiro - Boston MA, US
Philip Romero - Pasadena, CA
Robert S. Langer - Newton MA, US
Frances Arnold - La Canda Flintridge, CA
Alan Preadip Jasanoff - Combridge MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

A61B 5/055
G01N 24/08
G01N 33/20
G01N 33/68
C12Q 1/26
C07H 21/00
C12N 15/63
C12N 5/00
C07K 2/00

US Classification:

424 93, 436173, 436 73, 436 86, 436 98, 436129, 436111, 436 81, 436 96, 436 89, 436 94, 435 25, 536 231, 4353201, 435325, 530300

Abstract:

The present invention generally relates to Magnetic Resonance Imaging (MRI) analysis of the location, presence, and/or quantity of a particular molecule or material. In some embodiments, the invention relates to compositions and methods for determination of an analyte, wherein a compositions may produce an MRI signal that can be affected by the presence of a particular composition (e.g., analyte). In a particular embodiment, the composition comprises a protein. The invention also provides related nucleic acid molecules, polypeptides, and fragments thereof. Compositions of the invention may exhibit reduced toxicity and may be readily delivered in vivo. Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like.

US Patent:

20190032118, Jan 31, 2019

Filed:

Feb 15, 2018

Appl. No.:

15/897824

Inventors:

- Cambridge MA, US
Geoffrey Alan Otto - Brookline MA, US
Alexander N. Parker - Boston MA, US
Philip James Stephens - Lexington MA, US
Sean R. Downing - Methuen MA, US
Mirna Jarosz - Palo Alto CA, US
Mikhail G. Shapiro - San Francisco CA, US
Roman Yelensky - Newton MA, US

International Classification:

C12Q 1/6827
C12Q 1/6874

Abstract:

A method of analyzing a tumor sample comprising: