Mina Yaar

US Patent:

6696303, Feb 24, 2004

Filed:

May 29, 2001

Appl. No.:

09/866898

Inventors:

Barbara A. Gilchrest - Boston MA
Mina Yaar - Sharon MA

Assignee:

Trustees of Boston University - Boston MA

International Classification:

G01N 33563

US Classification:

436512, 436501, 435 71, 435 721, 435 78, 530300, 514 2

Abstract:

Methods for evaluating the risk of an individual to develop Alzheimers disease using cultured neural crest-derived melanocytes are described. Also described are methods of therapy for Alzheimers disease using peptides that bind to the neurotrophin receptor (p75 ) and competitively inhibit the binding of -amyloid to the p75.

US Patent:

6867179, Mar 15, 2005

Filed:

Aug 4, 2000

Appl. No.:

09/632748

Inventors:

Barbara A. Gilchrest - Boston MA, US
Mina Yaar - Sharon MA, US
Mark Eller - Boston MA, US

Assignee:

Trustees of Boston University - Boston MA

International Classification:

A61K038/08
A61K038/17
A61K038/18

US Classification:

514 2, 514 12, 514 17, 514 15

Abstract:

Methods to control, or manipulate, melanocyte and keratinocyte cell death are disclosed. In particular, a method of preventing epidermal melanocyte cell loss due to injury in a vertebrate is disclosed. Also disclosed is a method of inducing hair growth in a vertebrate, a method of inducing hair color in a vertebrate, a method of inducing skin color in a vertebrate, a method of treating baldness in an individual, and a method of treating alopecia areata in an individual.

US Patent:

7033829, Apr 25, 2006

Filed:

Apr 12, 2002

Appl. No.:

10/122633

Inventors:

Barbara A. Gilchrest - Boston MA, US
Mark S. Eller - Boston MA, US
Mina Yaar - Sharon MA, US

Assignee:

Trustees of Boston University - Boston MA

International Classification:

C12Q 3/00

US Classification:

435375, 435 6, 435325, 435377, 514 44, 536 231, 536 245

Abstract:

Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e. g. , human) an effective amount of a composition comprising pTT or a composition comprising one or more oligonucleotides which share at least 50% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed.

US Patent:

7094766, Aug 22, 2006

Filed:

Mar 31, 2000

Appl. No.:

09/540843

Inventors:

Barbara A. Gilchrest - Boston MA, US
Mina Yaar - Sharon MA, US
Mark Eller - Boston MA, US

Assignee:

Trustees of Boston University - Boston MA

International Classification:

A61K 31/70
A01N 43/04

US Classification:

514 44

Abstract:

Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative or allergically mediated diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed.

US Patent:

7196055, Mar 27, 2007

Filed:

Feb 4, 1998

Appl. No.:

09/018194

Inventors:

Barbara A. Gilchrest - Boston MA, US
Mina Yaar - Sharon MA, US
Mark S. Eller - Boston MA, US

Assignee:

Trustees of Boston University - Boston MA

International Classification:

A61K 38/00
A61K 38/16

US Classification:

514 2, 4241981, 530300

Abstract:

Methods to control, or manipulate, melanocyte and keratinocyte cell death are disclosed. In particular, a method of preventing epidermal melanocyte cell loss due to injury in a vertebrate is disclosed. Also disclosed is a method of inducing hair growth in a vertebrate, a method of inducing hair color in a vertebrate, a method of inducing skin color in a vertebrate, a method of treating baldness in an individual, and a method of treating alopecia areata in an individual.

US Patent:

20040254110, Dec 16, 2004

Filed:

Feb 24, 2004

Appl. No.:

10/785924

Inventors:

Barbara Gilchrest - Boston MA, US
Mina Yaar - Sharon MA, US

Assignee:

Trustees of Boston University - Boston MA

International Classification:

A61K038/18
A61K038/05

US Classification:

514/012000, 514/018000

Abstract:

Methods for evaluating the risk of an individual to develop Alzheimer's disease using cultured neural crest-derived melanocytes are described. Also described are methods of therapy for Alzheimer's disease using peptides that bind to the neurotrophin receptor (p75) and competitively inhibit the binding of -amyloid to the p75.

US Patent:

20050152860, Jul 14, 2005

Filed:

Oct 12, 2004

Appl. No.:

10/963432

Inventors:

Mina Yaar - Sharon MA, US
Hee-Young Park - Weston MA, US
Vladimir Botchkarev - Sharon MA, US
Barbara Gilchrest - Boston MA, US

Assignee:

Trustees of Boston University - Boston MA

International Classification:

A61K007/135
A61K009/127
A61K038/17

US Classification:

424062000, 514012000, 424450000

Abstract:

Methods are described wherein the skin of a vertebrate, or the skin or hair of a mammal can be lightened by administration of an agent, e.g., protein, peptide, active fusion protein, active fragment, or molecular mimic, that binds to BMP-4 transmembrane receptors on melanocytes and decreases the level of melanin synthesis. Also described are methods to identify molecules that mimic the function of BMP-4 in causing a decrease in melanin in melanocytes.

US Patent:

20060183704, Aug 17, 2006

Filed:

Apr 24, 2006

Appl. No.:

11/409706

Inventors:

Barbara Gilchrest - Boston MA, US
Mark Eller - Boston MA, US
Mina Yaar - Sharon MA, US

International Classification:

A61K 48/00

US Classification:

514044000

Abstract:

Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising pTT or a composition comprising one or more oligonucleotides which share at least 50% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed.