Ming H Chen

US Patent:

20090270397, Oct 29, 2009

Filed:

Apr 8, 2009

Appl. No.:

12/384777

Inventors:

Seth J. Orlow - New York NY, US
Ming Chen - Wayne NJ, US

International Classification:

A61K 31/53
A61K 31/4188
A61K 31/505
A61K 31/517
A61K 31/4985
A61K 31/4965
A61P 35/00

US Classification:

514245, 514393, 514275, 5142664, 514249, 51425506

Abstract:

A method of potentiating the efficacy of an antineoplastic agent such as temozolomide, comprises the administration of an antifolate agent as defined herein. Also disclosed are compositions, including pharmaceutical compositions, comprising the antineoplastic agent and an antifolate agent, and the use of such compounds and compositions thereof to treat a variety of cancers, such as melanoma. Unit dosage forms and kits are also contemplated and disclosed.

US Patent:

62219383, Apr 24, 2001

Filed:

Apr 4, 2000

Appl. No.:

9/543020

Inventors:

Ming J. Chen - Valley Cottage NY
Frederick D. Osterholtz - Pleasantville NY

Assignee:

OSi Specialities Inc. - Tarrytown NY

International Classification:

C08F 800

US Classification:

524114

Abstract:

A method of preparing a coating or a sealant wherein a class of epoxysilanes; optionally, an emulsifier; water; a polymer containing a functional group with an active hydrogen; and a curing catalyst are mixed together.

US Patent:

61274623, Oct 3, 2000

Filed:

Jul 30, 1997

Appl. No.:

8/902127

Inventors:

Ming J. Chen - Valley Cottage NY
Frederick D. Osterholtz - Pleasantville NY

Assignee:

OSi Specialities, Inc. - Greenwich CT

International Classification:

C08F 800

US Classification:

524114

Abstract:

The present invention provides stable epoxy silane solutions and emulsions and methods for the preparation of stable epoxy-silane solutions and emulsions comprising: (I) a water insoluble or slightly soluble epoxysilane; (II) optionally, an emulsifier; (III) water; (IV) a water dispersible polymer containing a functional group with an active hydrogen; and (V) a catalyst. Also provided are two part systems such that an epoxysilane solution or emulsion comprising components (I)-(III) are combined and the components (IV) and (V) may be added upon use of components (I) to (III). Moreover, additional components, such as pH buffers may be added. Said compositions may be used for, among other things, coatings, adhesives and sealants. The water epoxy functional silane for use herein are of the general structure R. sup. 1. sub. a R. sup. 2. sub. b Si(OR. sup. 3). sub. 4-a-b where R. sup.

US Patent:

58279229, Oct 27, 1998

Filed:

Feb 28, 1997

Appl. No.:

8/808113

Inventors:

Ming J. Chen - Valley Cottage NY
Frederick D. Osterholtz - Pleasantville NY

Assignee:

OSi Specialties, Inc. - Greenwich CT

International Classification:

C08L 8300

US Classification:

524837

Abstract:

Curable composition comprising a stable, water dispersible, curable polymer containing a sterically hindered alkoxylated silane group at 0. 1 to 75 weight percent of the total composition; a water dispersible or water soluble, hydrolytically stable organotin catalyst, at 0. 1 to 10 weight percent of the total composition; and water at 99. 8 to 24. 9 weight percent of the total composition are taught herein. These compositions are useful as adhesives, sealants and paints. The compositions have improved properties including solvent resistance, adhesion, hardness, abrasion resistance and mar resistance. Particular catalysts for use herein include mercaptoalcohol, mercaptide and sulfide forms of diorganotins having either a Sn--S or Sn. dbd. S bond, and include dibutyltin dimercaptide and dibutyltin bis(1-thioglycerol).