Ming C Li

US Patent:

8412465, Apr 2, 2013

Filed:

Apr 7, 2010

Appl. No.:

12/755637

Inventors:

Wenjiang Fu - Okemos MI, US
Yalu Wen - East Lansing MI, US
Ming Li - Lansing MI, US

Assignee:

Board of Trustees of Michigan State University - East Lansing MI

International Classification:

G06F 19/00
C12Q 1/68

US Classification:

702 20, 435 61

Abstract:

This invention contemplates an accurate and efficient estimation of gene copy number using oligonucleotide microarrays. The method integrates gene copy number data obtained from perfect match and mismatch probe sequence structure intensities and probe binding affinities. In one embodiment, an accurate determination of single nucleotide polymorphisms (SNPs) sequences is obtained. In another embodiment, an accurate detection and determination of DNA copy number alteration is obtained. In another embodiment, an accurate estimation for RNA gene expression is obtained.

US Patent:

20110059435, Mar 10, 2011

Filed:

Feb 6, 2006

Appl. No.:

12/091395

Inventors:

Bert Vogelstein - Baltimore MD, US
Frank Diehl - Baltimore MD, US
Kenneth W. Kinzler - Bel Air MD, US
Ming Li - Baltimore MD, US

Assignee:

THE JOHN HOPKINS UNIVERSITY - BALTIMORE MD

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

Improvements on the basic method used for BEAMing increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various DNA polymerases and have permitted the detection of rare and subtle mutations in DNA isolated from plasma of cancer patients.

US Patent:

20120035702, Feb 9, 2012

Filed:

Apr 23, 2010

Appl. No.:

13/265315

Inventors:

Keith Horvath - Washington DC, US
Dumitru Mazilu - Lutherville MD, US
Ming Li - Potomac MD, US

International Classification:

A61F 2/84
A61F 2/82

US Classification:

623 111, 623 116, 623 134, 623 146

Abstract:

An expandable stent () for use in the implantation of a valve prosthesis () using a delivery system () is disclosed. The self-expandable stent () includes a tubular lattice structure () defined by longitudinally aligned rods () connected to V- shaped struts () for forming a plurality of interconnected chevron-shaped six-sided polygons () that define a distal end zone () and a middle zone () of the tubular lattice structure (). A flare () or bend may be defined along opposite ends of each rod () to properly seat and prevent undue torsion of the stent () and valve prosthesis () during deployment and placement of the stent () within the lumen.

US Patent:

57042268, Jan 6, 1998

Filed:

Jun 24, 1996

Appl. No.:

8/668899

Inventors:

Henry Beckwith - Ypsilanti MI
Ming Li - Grosse Ile MI

Assignee:

Ford Motor Company - Dearborn MI

International Classification:

F25B 4300
B61G 508

US Classification:

62503

Abstract:

There is provided herein a refrigerant receiver for use in an automotive air conditioning system. The receiver includes a generally cylindrical body, a circular closure member secured at one end of the body and a manifold member configured to engage the closure member. The manifold includes a bottom surface having a stepped configuration which sealingly engages a corresponding stepped surface on the closure member. A single threaded fastener is utilized to secure the manifold to the closure member.

US Patent:

20230059264, Feb 23, 2023

Filed:

Aug 18, 2022

Appl. No.:

17/890864

Inventors:

- College Park MD, US
- Durham NC, US
Jason Madjdi AMINI - Takoma Park MD, US
Kenneth WRIGHT - Berwyn Heights MD, US
Neal PISENTI - Laurel MD, US
Hermann UYS - Annapolis MD, US
Ming LI - Takoma Park MD, US
Michael Lurie GOLDMAN - Annapolis MD, US
Jeremy Matthew SAGE - Acton MA, US
Kai Makoto HUDEK - Hyattsville MD, US
Yunseong NAM - North Bethesda MD, US
Nikodem GRZESIAK - Morges, CH
Reinhold BLUMEL - Middletown CT, US

International Classification:

H01J 49/42
H01J 49/00

Abstract:

The use of multiple ion chains in a single ion trap for quantum information processing (QIP) systems is described. Each chain can have its own set of laser beams with which to implement and operate quantum gates within that chain, where each chain may therefore correspond to a single quantum computing register or core. Operations can be performed in parallel across all of these chains as they can be treated independently from each other. To implement and operate quantum gates between different chains, neighboring chains are merged into a single, larger chain, in which one can perform quantum gates between any of the ions in the larger chain. The combined chains can then be separated again by another shuttling event as needed. To implement and operate quantum gates between ions which do not occupy neighboring chains, swap gates can be used via a sequence of intervening chains.

US Patent:

20150150466, Jun 4, 2015

Filed:

Apr 26, 2013

Appl. No.:

14/396064

Inventors:

- EINDHOVEN, NL
Ming Li - Potomac MD, US
Samuel Kadoury - Olney MD, US
Ankur Kapoor - Cranbury MD, US
Nicolaas Jan Noordhoek - Best, NL
Alessandro Guido Radaelli - Oirschot, NL
Bart Carelsen - Eindhoven, NL
Bradford Johns Wood - Bethesda MD, US

International Classification:

A61B 5/01
A61B 6/03
A61B 5/00
A61B 19/00
A61B 18/20
A61B 18/14
A61B 18/18
A61N 7/02
G06T 7/00
A61B 6/00

Abstract:

A computing device includes a thermal map generator ()that generates a thermal map for image data voxels or pixels representing a volume or region of interest of a subject based on thermometry image data, which includes voxels or pixels indicating a change in a temperature in the volume or region of interest, and a predetermined change in value to temperature lookup table () and a display () that visually presents the thermal map in connection with image data of the volume of interest. A method includes generating a thermal map for image data voxels or pixels representing a volume or region of interest of a subject based on thermometry image data, which includes voxels or pixels indicating a change in a temperature in the volume or region of interest, and a predetermined change in voxel or pixel value to temperature lookup table.

US Patent:

20140357554, Dec 4, 2014

Filed:

May 12, 2014

Appl. No.:

14/275749

Inventors:

- Danbury CT, US
Robert Hauser - Columbia MD, US
Errol De Souza - Cambridge MA, US
Ming Li - Yorktown Heights NY, US
Bryan R. Wilson - Brewster NY, US

International Classification:

A61K 47/02
A61K 38/28

US Classification:

514 64

Abstract:

Compositions and methods for modulating injection site pain associated with rapid acting injectable insulin formulations have been developed for subcutaneous injection. The formulations contain insulin in combination with a zinc chelator such as ethylenediaminetetraacetic acid (“EDTA”), a dissolution/stabilization agent such as citric acid, a magnesium salt, and, optionally, additional excipients. New presentations include rapid acting concentrated insulin formulations and a way to enhance the absorption of commercially available rapid acting analog formulations by mixing them with a vial containing dry powder excipients that accelerate their absorption. Devices for mixing excipient and insulin together at the time of administration, while minimizing residence time of the mixture, are also described.

US Patent:

20140113856, Apr 24, 2014

Filed:

Mar 14, 2013

Appl. No.:

13/826806

Inventors:

Biodel Inc - , US
Robert Hauser - Columbia MD, US
Ming Li - Yorktown Heights NY, US
Bryan R. Wilson - Brewster NY, US

International Classification:

A61K 47/02
A61K 38/28

US Classification:

514 64

Abstract:

Compositions and methods for modulating injection site pain associated with rapid acting injectable insulin formulations have been developed for subcutaneous injection. The formulations contain insulin in combination with a zinc chelator such as ethylenediaminetetraacetic acid (“EDTA”), a dissolution/stabilization agent such as citric acid, a magnesium salt, and, optionally, additional excipients. New presentations include rapid acting concentrated insulin formulations and a way to enhance the absorption of commercially available rapid acting analog formulations by mixing them with a vial containing dry powder excipients that accelerate their absorption. Devices for mixing excipient and insulin together at the time of administration, while minimizing residence time of the mixture, are also described.