Ming Hsien Wu

US Patent:

6379899, Apr 30, 2002

Filed:

Mar 13, 2001

Appl. No.:

09/805674

Inventors:

Edwin Ullman - Atherton CA
Ming Wu - Castro Valley CA

Assignee:

Discoverx - Fremont CA

International Classification:

C12Q 168

US Classification:

435 6, 435 912

Abstract:

Methods and compositions are provided for performing isothermal amplification of a nucleic acid target employing probes characterized by having a masked RNA polymer promoter unable to bind to a complementary initiator oligonucleotide and RNA polymerase and initiate transcription, a dsDNA sequence which when invaded by the target nucleic acid exposes the masked promoter to initiate transcription, and a template sequence, a portion of which is normally included in the dsDNA region, which when copied produces a product that can reinitiate the process of invading the dsDNA region and initiating transcription of another copy.

US Patent:

6799357, Oct 5, 2004

Filed:

Sep 5, 2002

Appl. No.:

10/235080

Inventors:

Neal Webb - San Jose CA
Philippe Poncet - Sandy Hook CT
Ming H. Wu - Bethel CT
Scott Carpenter - Fremont CA
Jesse Perez - Newark CA
Paul Adler - Livermore CA

Assignee:

Memry Corporation - Bethel CT

International Classification:

B23P 1700

US Classification:

29423, 7237001

Abstract:

The manufacture of seamless tubes in which the process includes providing an assembly having a metal tube blank, and an elongate metal core of shape memory effect material which is surrounded and contacted by the tube blank with a minimal gap. The assembly is elongated by mechanical working thereof at an elevated temperature until the tube blank has been converted into a tube of desired dimensions. After the elongation step, the core is subjected to a treatment which results in the core being in a stretched condition throughout its length, and does not substantially stretch the tube. The core is removed from the tube, and subsequently subjected to drawing passes over a nondeformable mandrel thereby refining the precision of diametric and wall dimensions with improved ID and OD surface quality. There is also decoring and reinserting to improve final dimensions which results in the ability to fabricate smaller, longer tubes.

US Patent:

6958132, Oct 25, 2005

Filed:

May 31, 2002

Appl. No.:

10/161220

Inventors:

Pei Yu Chiou - Los Angeles CA, US
Ming C. Wu - Pacific Palisades CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

B01L003/02
G01N001/10
G01N021/00
G01N021/29
C02F001/40

US Classification:

422100, 422 55, 422 81, 422 8205, 436180, 436164, 204600

Abstract:

The invention is related to methods and apparatus that manipulate droplets in a microfluidic environment. Advantageously, embodiments of the invention manipulate droplets by controlling the electro-wetting characteristics of a surface with light, thereby inducing a gradient in the surface tension of a droplet. The gradient in the surface tension propels the droplet by capillary force. A variety of operations, such as transporting, joining, cutting, and creating can be performed. Advantageously, embodiments of the invention obviate the need to create a relatively large and complex control electrode array. A plurality of photoconductive cells or a layer of a photoconductive material selectively couples an electrode carrying an electrical bias to otherwise floating conductive cells in response to a beam of light. The electrical bias applied to the conductive cell generates a localized electric field, which can change the contact angle of the droplet, thereby permitting the droplet to be propelled.

US Patent:

7003231, Feb 21, 2006

Filed:

Apr 19, 2001

Appl. No.:

09/839693

Inventors:

Winston Way - Irvine CA, US
Ming Chia Wu - Irvine CA, US
Ming-Bing Chen - Irvine CA, US

Assignee:

OpVista, Inc. - Irvine CA

International Classification:

H04B 10/04

US Classification:

398186, 398183

Abstract:

An optical carrier notch filter includes an optical coupler with at least first, second and third ports. The first port is configured to receive an output that includes an optical carrier and interleaved optical single sideband signals. An optical bandpass filter is coupled to a port of the optical coupler. The optical bandpass filter separates the output into a transmitted signal that contains the optical carrier, and a reflected signal that includes the interleaved optical single sideband signals. The reflected signal is reflected from the optical bandpass filter to the third port of the optical coupler.

US Patent:

7053737, May 30, 2006

Filed:

Sep 19, 2002

Appl. No.:

10/251677

Inventors:

Robert N. Schwartz - Costa Mesa CA, US
Ming Wu - Los Angeles CA, US
Tsung-Yuan Hsu - Westlake Village CA, US
Adele E. Schmitz - Newbury Park CA, US
Robert Y. Loo - Agoura Hills CA, US
James H. Schaffner - Chatsworth CA, US
Gregory L. Tangonan - Oxnard CA, US

Assignee:

HRL Laboratories, LLC - Malibu CA
The Regents of the University of California - Oakland CA

International Classification:

H01H 51/22

US Classification:

335 78, 200181

Abstract:

A micro-electromechanical system (MEMS) switch formed on a substrate, the switch comprising a transmission line formed on the substrate, a substrate electrostatic plate formed on the substrate, and an actuating portion. The actuating portion comprises a cantilever anchor formed on the substrate and a cantilevered actuator arm extending from the cantilever anchor. Attraction of the actuator arm toward the substrate brings an electrical contact into engagement with the portions of the transmission line separated by a gap, thus bridging the transmission line gap and closing the circuit. In order to maximize electrical isolation between the transmission line and the electrical contact in an OFF-state while maintaining a low actuation voltage, the actuator arm is bent such that the minimum separation distance between the transmission line and the electrical contact is equal to or greater than the maximum separation distance between the substrate electrostatic plate and arm electrostatic plate.

US Patent:

7206520, Apr 17, 2007

Filed:

Feb 21, 2006

Appl. No.:

11/358990

Inventors:

Winston Way - Irvine CA, US
Ming Chia Wu - Irvine CA, US
Ming-Bing Chen - Irvine CA, US

Assignee:

OpVista Incorporated - Milpitas CA

International Classification:

H04B 10/04

US Classification:

398186, 398183

Abstract:

An optical carrier notch filter includes an optical coupler with at least first, second and third ports. The first port is configured to receive an output that includes an optical carrier and interleaved optical single sideband signals. An optical bandpass filter is coupled to a port of the optical coupler. The optical bandpass filter separates the output into a transmitted signal that contains the optical carrier, and a reflected signal that includes the interleaved optical single sideband signals. The reflected signal is reflected from the optical bandpass filter to the third port of the optical coupler.

US Patent:

7378655, May 27, 2008

Filed:

Apr 9, 2004

Appl. No.:

10/821790

Inventors:

Yu-Chong Tai - Pasadena CA, US
Matthieu Liger - Pasadena CA, US
Ming C. Wu - Orinda CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

G01J 5/00

US Classification:

2503381

Abstract:

A method for manufacturing a sensing device, such as a bolometer device or other devices. The method includes providing a substrate, e. g. , silicon wafer. The method includes forming a first reflection layer overlying the substrate and forming a first electrode layer overlying the substrate. The method includes forming a sacrificial layer overlying a portion of the first reflection layer and a portion of the first electrode layer. The sacrificial layer is patterned using photolithography techniques. The patterned sacrificial layer corresponds to a cavity region. The method also forms a second electrode layer overlying the sacrificial layer and forms an elastic layer overlying the patterned sacrificial layer. The elastic layer encloses the cavity region corresponding to the patterned sacrificial layer. The method releases the sacrificial layer to form an opening in the cavity region.

US Patent:

7612355, Nov 3, 2009

Filed:

Apr 12, 2005

Appl. No.:

11/105304

Inventors:

Ming Chiang Wu - Orinda CA, US
Pei Yu Chiou - Los Angeles CA, US
Aaron T. Ohta - Berkeley CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 21/86
G01V 8/00

US Classification:

25055904, 204547, 204603

Abstract:

An optical image-driven light induced dielectrophoresis (DEP) apparatus and method are described which provide for the manipulation of particles or cells with a diameter on the order of 100 μm or less. The apparatus is referred to as optoelectric tweezers (OET) and provides a number of advantages over conventional optical tweezers, in particular the ability to perform operations in parallel and over a large area without damage to living cells. The OET device generally comprises a planar liquid-filled structure having one or more portions which are photoconductive to convert incoming light to a change in the electric field pattern. The light patterns are dynamically generated to provide a number of manipulation structures that can manipulate single particles and cells or groups of particles/cells. The OET preferably includes a microscopic imaging means to provide feedback for the optical manipulation, such as detecting position and characteristics wherein the light patterns are modulated accordingly.