Minh Vo - Sugar Hill GA, US Cory Anderson - Alpharetta GA, US
Assignee:
Syntheon, LLC. - Miami FL
International Classification:
A61F 7/12 A61F 7/00 A61M 29/00
US Classification:
604 9601, 604113, 607104
Abstract:
A catheter for treatment of chronic total occlusions includes an occlusion breach device, a catheter body made of a temperature-dependent softening, shape-memory, thermoplastic polymer having a first flexible state and a second stiff state. The catheter body has a heat transfer conduit and a conduit for slidably receiving the breach device. A heat-transferring device selectively changes a temperature of the heat transfer conduit to, thereby, change stiffness of the catheter body between the two states. To treat a CTO with the catheter, it is warmed above the glass-transition temperature and below the melting-temperature to make the catheter flexible. The catheter has a shape when inserted at the occlusion site and is cooled to, thereby, stiffen. Breaching of the occlusion is assisted with the stiff catheter. The catheter is removed by warming the polymer.
Method And System For Maintaining Aseptic Conditions In The Storage Of Biologics
Technologies are generally described for the storage of biologics and other fluid materials while maintaining aseptic conditions. A system may include a storage body providing a reservoir for containing the materials. A cap may couple to the storage body forming a fluid-tight seal. A port may be provided for transferring the materials. A seal, or valve, may be provided within the port. The seal may be configured to close off the reservoir unless acted upon to release the materials through the port. A movable member may make up part of the storage body. The movable member may be configured to change a reservoir volume of the storage body in response to changes in a volume of the materials. The reservoir may become smaller as the materials are released. Multi-dose volumes of fluid materials may be stored for repeated access with reduced risk of contamination and reduction in shelf life.
A prosthetic valve comprising a conical shaped sheet member comprising an extracellular matrix (ECM) composition, the sheet member having a plurality of open slit regions that are disposed uniformly on linear planes that are parallel to the sheet member longitudinal axis, and a proximal annulus engagement end diameter and length ratio in the range of 5:1 to 2:1.
A prosthetic valve comprising a conical shaped sheet member comprising an extracellular matrix (ECM) composition, the sheet member having a plurality of ribbons projecting the sheet member proximal end, the distal ends of the ribbons being positioned proximate each other, wherein the sheet member comprises a conical shape.
A prosthetic valve comprising a conical shaped sheet member comprising an extracellular matrix (ECM) composition, the sheet member having a plurality of open slit regions that are disposed uniformly on linear planes that are parallel to the sheet member longitudinal axis, a proximal annulus engagement end diameter and length ratio in the range of 5:1 to 2:1 and at least one valve leaflet.
- Roswell GA, US Minh X Vo - Sugar Hill GA, US Carlos C Chang - Atlanta GA, US Selvamuthu k Natarajan - Alpharetta GA, US
International Classification:
A61F 2/24 A61L 27/36 A61L 27/18 A61L 27/54
Abstract:
A prosthetic valve comprising a plurality of ribbons comprising an extracellular matrix (ECM) composition, the proximal ends of the plurality of ribbons being positioned circumferentially and proximate each other, the distal ends of the plurality of ribbons also being positioned proximate each other, wherein a conical shaped valve member is formed.
A prosthetic valve comprising a conical shaped sheet member comprising an extracellular matrix (ECM) composition and an internal multi-link support stent structure, the sheet member having a plurality of open slit regions that are disposed uniformly on linear planes that are parallel to the sheet member longitudinal axis, and a proximal annulus engagement end diameter and length ratio in the range of 5:1 to 2:1.
Complete Human Skin Organ Generated From Culture-Expanded Cells
- Atlanta GA, US Bryan T. Marshall - Atlanta GA, US Minh Vo - Sugar Hill GA, US
International Classification:
A61K 35/36
US Classification:
424 937
Abstract:
Systems and methods can support generation of a full-thickness, human skin organ from tissue culture expanded cells. Human dermal and epidermal progenitor cells can be isolated from human tissues. Isolated cells may be cultured as epidermal cells while other isolated cells may be separately cultured as dermal cells. The cultured epidermal cells and dermal cells may be combined for co-culturing. The co-cultured cells may be suspended within a slurry. The co-cultured cells may be implanted onto a recipient organism for generation of a full-thickness skin organ comprising fully cycling hair follicles, adipose tissue, and other skin organ structures.
Isbn (Books And Publications)
Roadmap to Enlightenment: A New Path for the Spirit