Miroslav Miroslav Petro

US Patent:

6345528, Feb 12, 2002

Filed:

May 24, 2001

Appl. No.:

09/866428

Inventors:

Miroslav Petro - Sunnyvale CA
Adam Safir - Oakland CA
Ralph B. Nielsen - San Jose CA
Eric D. Carlson - Palo Alto CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

G01N 3030

US Classification:

73 6152, 73 6157, 73 6156, 422 70, 210663, 95 87

Abstract:

Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

US Patent:

6406632, Jun 18, 2002

Filed:

Nov 8, 2000

Appl. No.:

09/710801

Inventors:

Adam Safir - Oakland CA
Miroslav Petro - Sunnyvale CA
Ralph B. Nielsen - San Jose CA
Thomas S. Lee - Palo Alto CA
Jean M. J. Fréchet - Oakland CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01D 1508

US Classification:

210656, 2101982, 210739, 73 6152, 422 70, 436161

Abstract:

Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

US Patent:

6436292, Aug 20, 2002

Filed:

Sep 26, 2000

Appl. No.:

09/670503

Inventors:

Miroslav Petro - Sunnyvale CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01D 1508

US Classification:

210656, 210659, 210143, 2101982, 73 6152, 436161, 422 70

Abstract:

High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine parallel chromatographic separation of a plurality of samples with a detection technique that involves post-separation treatment of the plurality of samples to enhance one or more properties of the sample or of a component thereof, followed by detection of the one or more enhanced properties. Selective, tunable detection schemes are achievable, and are particularly advantageous as applied in connection with combinatorial chemistry, combinatorial material science and more particularly, combinatorial synthesis and screening of polymeric materials.

US Patent:

6454947, Sep 24, 2002

Filed:

Nov 28, 2000

Appl. No.:

09/728375

Inventors:

Adam Safir - Berkeley CA
Miroslav Petro - San Jose CA
Ralph B. Nielsen - San Jose CA
Eric Carlson - Palo Alto CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01D 1508

US Classification:

210656, 210659, 436161, 436164, 73 6156

Abstract:

A method is disclosed for characterizing a plurality of non-biological polymer samples. The method includes the steps of injecting a first non-biological polymer sample into a mobile-phase of a liquid chromatography system, chromatographically separating at least one sample component of the injected first sample from other sample components thereof in a chromatographic column, detecting at least one property of the separated sample component of the first sample, injecting a second non-biological polymer sample into the mobile-phase of the liquid chromatography system while advancing the first sample to the chromatographic column, chromatographically separating at least one sample component of the injected second sample from other sample components thereof, and detecting at least one property of the separated sample component of the second sample.

US Patent:

6461515, Oct 8, 2002

Filed:

Nov 28, 2000

Appl. No.:

09/728729

Inventors:

Adam Safir - Berkeley CA
Miroslav Petro - San Jose CA
Ralph B. Nielsen - San Jose CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01D 1508

US Classification:

210656, 210659, 436161, 436164, 73 6156

Abstract:

A method is disclosed for characterizing non-biological polymers using liquid chromatography that is particularly useful in polymer research programs. The method includes the steps of providing a library of four or more non-biological polymer samples, with each of the four or more polymer samples being polymerization product mixtures that result from polymerization reactions that are varied with respect to a factor affecting polymerization. Each of the four or more polymer samples resides in the reaction vessel in which they were formed. The method further includes sampling first and second polymer samples from the reaction vessels in which they were formed, supplying a mobile phase in parallel through each of a first chromatographic column and a second chromatographic column of a liquid chromatography system, injecting the first and second polymer samples into the mobile phase of the first and second chromatographic columns, respectively, simultaneously separating at least one sample component of the injected first and second samples from other sample components thereof in the respective chromatographic columns, and detecting a property of at least one of the separated sample components of each of the first and second samples.

US Patent:

6475391, Nov 5, 2002

Filed:

Feb 6, 2001

Appl. No.:

09/778241

Inventors:

Adam Safir - Oakland CA
Miroslav Petro - Sunnyvale CA
Ralph B. Nielsen - San Jose CA
Thomas S. Lee - Palo Alto CA
Jean M. J. Fréchet - Oakland CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01D 1508

US Classification:

210656, 210635, 436161, 436174, 73 6155, 73 6156

Abstract:

A method is disclosed for characterizing a plurality of non-biological polymer samples. The method includes the steps of injecting four or more non-biological polymer samples into a mobile-phase of a liquid chromatography system, chromatographically separating at least one sample component or polymer molecule of each of the four or more injected polymer samples from other sample components or polymer molecules thereof in a chromatographic column, and serially detecting a property of the four or more non-biological polymer samples or of components or polymer molecules thereof with a flow-through detector at an average sample throughput of not more than about 10 minutes per sample.

US Patent:

6491816, Dec 10, 2002

Filed:

Sep 18, 2001

Appl. No.:

09/956199

Inventors:

Miroslav Petro - Santa Clara CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01D 1508

US Classification:

2101982, 210143, 210656, 210659, 73 6152, 422 70

Abstract:

High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine sequential, serial injection of a plurality of samples into mobile-phases supplied in parallel to two or more chromatographic columns, such that staggered, parallel separation of the plurality of samples is effected. Because injection of samples is relatively fast as compared to separation, substantial efficiencies are gained with respect to overall sample throughput. The disclosed HPLC methods and systems are preferably applied in connection with combinatorial chemistry, combinatorial material science and more particularly, combinatorial synthesis and screening of polymeric materials.

US Patent:

6491823, Dec 10, 2002

Filed:

Nov 28, 2000

Appl. No.:

09/728372

Inventors:

Adam Safir - Berkeley CA
Miroslav Petro - San Jose CA
Ralph B. Nielsen - San Jose CA
Eric Carlson - Palo Alto CA

Assignee:

Symyx Technologies, Inc. - Santa Clara CA

International Classification:

B01D 1508

US Classification:

210656, 2101982, 436161, 73 6152

Abstract:

Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.