Mohamed A Ismail

US Patent:

20100249175, Sep 30, 2010

Filed:

Jun 29, 2006

Appl. No.:

11/478453

Inventors:

W. David Wilson - Atlanta GA, US
David W. Boykin - Atlanta GA, US
Elizabeth W. White - Atlanta GA, US
Mohamed A. Ismail - Atlanta GA, US
Arvind Kumar - Lilburn GA, US
Rupesh Nanjunda - Atlanta GA, US
Richard R. Tidwell - Pittsboro NC, US

International Classification:

A61K 31/437
C12P 19/34
C12N 5/071
C12N 5/02
A61K 31/4178
C07H 21/04
C07D 471/04
C07D 405/14
A61P 35/04

US Classification:

514300, 435 911, 435366, 435375, 514394, 536 231, 546121, 5483047

Abstract:

Dicationic compounds that are highly selective for binding G-quadruplex DNA are described. Several compounds exhibit groove binding toward G-quadruplex DNA and in vitro and in vivo activity versus The compounds represent novel drugs for the treatment of cancer, malaria, leishmania, and trypanosomiasis.