Myles E Pierson

US Patent:

55021646, Mar 26, 1996

Filed:

Aug 22, 1994

Appl. No.:

8/294203

Inventors:

James D. Rosamond - Honeoye NY
Myles E. Pierson - Pittsford NY

Assignee:

Fisons Corporation - Rochester NY

International Classification:

A61K 3800
C07K 700
C07K 706

US Classification:

530329

Abstract:

Compounds of formula I, ##STR1## wherein M is Met, DMet, MeMet, MetO, Ahx, DAhx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala or Lys, G is Gly, DAla, Pro, Ala,. beta. Ala or Sar; W is Trp, MeTrp, Ala or Nal; X is Met, MeMet, MetO, Ahx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala, Phe, Lys or Lys(R. sup. 8); J is Asp, DAsp, MeAsp, Asp(OBn), Ala or MeDAsp; F. sup. 1 is (S)--NH, (R)--NH, (S)--R. sup. 1 N or (R)--R. sup. 2 N; F. sup. 2 is H, Cl, I, Br, F, NO. sub. 2, NH. sub. 2, R. sup. 3 or OR. sup. 4 ; Z is NH. sub. 2, NHR. sup. 5 or NR. sup. 5 R. sup. 6 ; R. sup. 1, R. sup. 2, R. sup. 3, R. sup. 5 and R. sup. 6 are alkyl C. sub. 1-6 ; R. sup. 4 is H or alkyl C. sub. 1-4 ; R. sup. is OH or OSO. sub. 3 H; and pharmaceutically acceptable derivatives thereof; are useful as therapeutic agents, in particular in the inhibition of feeding.