Nan Suk Lee

US Patent:

20180148789, May 31, 2018

Filed:

Dec 1, 2015

Appl. No.:

15/532303

Inventors:

- Los Angeles CA, US
Nan Sook LEE - Pasadena CA, US
Robert H. CHOW - Pasadena CA, US

International Classification:

C12Q 1/6886
C12N 15/113
A61P 35/00

Abstract:

Provided herein are methods, such as diagnostic methods, for evaluating a tissue sample, such as a biopsy or cytology specimen of a subject to determine a likelihood of metastasis, a risk of tumor or cancer occurrence, or combinations thereof and provided herein are methods, such as a screening method, for determining the efficacy of a drug in reducing cell invasiveness. Also provided are methods of treatment, drugs, primers, and kits.

US Patent:

20180143180, May 24, 2018

Filed:

Jun 7, 2017

Appl. No.:

15/616275

Inventors:

- Los Angeles CA, US
Jae Youn HWANG - Los Angeles CA, US
Nan Sook LEE - Pasadena CA, US
K. Kirk SHUNG - Monterey Park CA, US
Andrew C. WEITZ - Pasadena CA, US

International Classification:

G01N 33/50

Abstract:

A method of determining invasion potential of a tumor cell includes exposing a tumor cell to an activity sensor; after exposing the tumor cell to the activity sensor, stimulating the tumor cell to cause a response in the cell that is reported by the activity sensor; detecting the level of response after stimulation of the tumor cell; and determining the invasion potential of the tumor cell based on the response. A system for determining the invasion potential of a tumor cell includes a sample stage that supports the tumor cell; a stimulator that focuses energy on the tumor cell to stimulate the tumor cell; and an imaging apparatus that observes an effect of the beam on the tumor cell.

US Patent:

20140087411, Mar 27, 2014

Filed:

Sep 27, 2013

Appl. No.:

14/040253

Inventors:

Andrew C. Weitz - Pasadena CA, US
Nan Sook Lee - Pasadena CA, US
Jae Youn Hwang - Los Angeles CA, US
Robert H. Chow - Pasadena CA, US
K. Kirk Shung - Monterey Park CA, US

Assignee:

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA

International Classification:

G01N 33/50

US Classification:

435 29, 4352887

Abstract:

A method of determining invasion potential of a tumor cell includes exposing a tumor cell to an activity sensor; after exposing the tumor cell to the activity sensor, stimulating the tumor cell to cause a response in the cell that is reported by the activity sensor; detecting the level of response after stimulation of the tumor cell; and determining the invasion potential of the tumor cell based on the response. A system for determining the invasion potential of a tumor cell includes a sample stage that supports the tumor cell; a stimulator that focuses energy on the tumor cell to stimulate the tumor cell; and an imaging apparatus that observes an effect of the beam on the tumor cell.