Nan M Zhang

US Patent:

7285555, Oct 23, 2007

Filed:

Sep 24, 2004

Appl. No.:

10/950542

Inventors:

Nan Zhang - Bayside NY, US

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

A61K 31/519
C07D 487/04
A61P 35/04

US Classification:

5142591, 544281

Abstract:

This invention relates to certain 6-aryl-7-halo-imidazo[1,2-a]pyrimidines or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals by promotion of microtubule polymerization. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof.

US Patent:

7507739, Mar 24, 2009

Filed:

Sep 24, 2004

Appl. No.:

10/950543

Inventors:

Nan Zhang - Bayside NY, US
Thai Nguyen - Fair Lawn NJ, US
Yanzhong Wu - Bronx NY, US
Wei Tong - Suffern NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 487/04
A61K 31/519
A61P 35/04

US Classification:

5142593, 544263

Abstract:

This invention relates to certain 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. The present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.

US Patent:

7524849, Apr 28, 2009

Filed:

Sep 24, 2004

Appl. No.:

10/950375

Inventors:

Nan Zhang - Bayside NY, US
Thai Nguyen - Fair Lawn NJ, US

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

C07D 239/42
C07D 239/48
A61K 31/505

US Classification:

51425505, 514256, 514275, 544295, 544323, 544324, 544328, 544330, 544331

Abstract:

This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or a pharmaceutically acceptable salt thereof. More specifically, the present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.

US Patent:

7915266, Mar 29, 2011

Filed:

Sep 19, 2007

Appl. No.:

11/903100

Inventors:

Nan Zhang - Bayside NY, US

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

A61P 35/00
A61K 31/519
C07D 487/04

US Classification:

5142591, 544281

Abstract:

This invention relates to methods for treating or inhibiting cancers in a mammal in need thereof, which comprises administering an effective amount of a 6-Aryl-7-halo-imidazo[1,2 -a]pyrimidine compound of the formula:.

US Patent:

RE42376, May 17, 2011

Filed:

May 21, 2010

Appl. No.:

12/785269

Inventors:

Allan Wissner - Ardsley NY, US
Dan M. Berger - New City NY, US
Philip R. Hamann - Thiells NY, US
Nan Zhang - Bayside NY, US
Philip Frost - Morris Township NJ, US

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

A61K 31/47
C07D 215/44

US Classification:

514313, 5142282, 5142352, 51425301, 514278, 514312, 546 19, 546153, 546159, 546160, 546171, 544 586, 544128, 544328, 544331, 544363

Abstract:

This invention provides compounds of formula I having the structure.

US Patent:

20060063784, Mar 23, 2006

Filed:

Sep 9, 2005

Appl. No.:

11/221846

Inventors:

Yanong Wang - Green Brook NJ, US
Ariamala Gopalsamy - Mahwah NJ, US
Erick Honores - Hoboken NJ, US
Lee Jennings - Chestnut Ridge NY, US
Steven Johnson - Amherst NY, US
Dennis Powell - Cortlandt Manor NY, US
Fuk-Wah Sum - Pomona NY, US
Biqi Wu - Nanuet NY, US
Nan Zhang - Bayside NY, US

International Classification:

A61K 31/519
C07D 487/04

US Classification:

514259300, 544281000

Abstract:

This invention relates to novel methods of use of certain pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. This invention also relates to novel methods of using these compounds as anti-proliferative agents in mammals, including humans.

US Patent:

20060063785, Mar 23, 2006

Filed:

Sep 9, 2005

Appl. No.:

11/221847

Inventors:

Yanong Wang - Green Brook NJ, US
Ariamala Gopalsamy - Mahwah NJ, US
Dennis Powell - Cortlandt Manor NY, US
Nan Zhang - Bayside NY, US

International Classification:

A61K 31/519
C07D 487/04

US Classification:

514259300, 544281000

Abstract:

This invention relates to novel pyrazolo[1,5-a]pyrimidine compounds and the therapeutically acceptable salts thereof. These compounds are useful as anti-proliferative agents in mammals, including humans.

US Patent:

20090192147, Jul 30, 2009

Filed:

Jan 30, 2009

Appl. No.:

12/363013

Inventors:

Nan Zhang - Bayside NY, US
Aranapakam Mudumbai Venkatesan - Rego Park NY, US
Tarek Suhayl Mansour - New City NY, US
Thai Hiep Nguyen - Fair Lawn NJ, US
James Thomas Anderson - Hillsdale NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/5383
C07D 471/00
A61K 31/437
C07D 487/00
A61K 31/4985

US Classification:

5142302, 546 94, 514294, 544344, 514250, 544101

Abstract:

The invention relates to [a]-fused indole compounds of the Formula II,or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein. The invention also relates to compositions comprising the compounds of Formula II, and methods for making and using the compounds.