Nan J Zhang

US Patent:

6521618, Feb 18, 2003

Filed:

Mar 28, 2001

Appl. No.:

09/820070

Inventors:

Diane Harris Boschelli - New City NY
Yanong Wang - Nanuet NY
Frank Charles Boschelli - New City NY
Dan Maarten Berger - New City NY
Nan Zhang - Bayside NY
Dennis William Powell - Cortlandt Manor NY
Fei Ye - Nanuet NY
Ayako Yamashita - Englewood NJ
Frenel Fils DeMorin - Thousand Oaks CA
Biqi Wu - Nanuet NY
Elsebe Geraldine Overbeek-Klumpers - Bergentheim, NL
Allan Wissner - Ardsley NY

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 315377

US Classification:

5142315, 51425213, 514312, 514313, 514314, 544106, 544111, 546 1, 546153, 546159, 546160

Abstract:

This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R , R , R , R , R , R , and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.

US Patent:

6638929, Oct 28, 2003

Filed:

Dec 29, 2000

Appl. No.:

09/751274

Inventors:

Dan M. Berger - New City NY
Minu D. Dutia - West Nyack NY
Frenel F. DeMorin - Nanuet NY
Diane H. Boschelli - New City NY
Dennis W. Powell - Westchester NY
Allan Wissner - Ardsley NY
Nan Zhang - Eastchester NY
Fei Ye - Nanuet NY
Biqi Wu - Nanuet NY

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31535

US Classification:

5142328, 51425303, 514290, 544259, 544126, 544361, 546101, 546160

Abstract:

This invention provides compounds of formula 1, having the structure which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.

US Patent:

6689772, Feb 10, 2004

Filed:

Dec 12, 2002

Appl. No.:

10/318213

Inventors:

Diane Harris Boschelli - New City NY
Yanong Wang - Nanuet NY
Frank Charles Boschelli - New City NY
Dan Maarten Berger - New City NY
Nan Zhang - Bayside NY
Dennis William Powell - Cortlandt Manor NY
Fei Ye - Audubon PA
Ayako Yamashita - Englewood NJ
Frenel Fils DeMorin - Thousand Oaks CA
Biqi Wu - Nanuet NY
Elsebe Geraldine Overbeek-Klumpers - Baam, NL
Allan Wissner - Ardsley NY

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 3133

US Classification:

514183, 5142315, 514313, 514300, 514314, 546122

Abstract:

This invention provides compounds of Formula (I), having the structure where T, Z, X, A, R , R , R , R , R , R , and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.

US Patent:

6987116, Jan 17, 2006

Filed:

Nov 21, 2003

Appl. No.:

10/719359

Inventors:

Diane Harris Boschelli - New City NY, US
Nan Zhang - Bayside NY, US
Ana Carolina Barrios Sosa - Warwick NY, US
Haris Durutlic - New Windsor NY, US
Biqi Wu - Nanuet NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/4365
A61K 31/496
A61K 31/5377
C07D 495/04
C07D 498/02

US Classification:

514301, 5142282, 5142338, 51425304, 546114, 544 61, 544127, 544362

Abstract:

This invention provides compounds of Formula (1a)-(1f) wherein:.

US Patent:

7105531, Sep 12, 2006

Filed:

Jul 10, 2003

Appl. No.:

10/618044

Inventors:

Dan M. Berger - New City NY, US
Minu D. Dutia - West Nyack NY, US
Frenel F. DeMorin - Nanuet NY, US
Diane H. Boschelli - New City NY, US
Dennis W. Powell - Westchester NY, US
Allan Wissner - Ardsley NY, US
Nan Zhang - Eastchester NY, US
Fei Ye - Nanuet NY, US
Biqi Wu - Nanuet NY, US

Assignee:

WYETH - Madison NJ

International Classification:

A61K 31/44
C07D 471/04

US Classification:

514292, 546 81

Abstract:

This invention provides compounds of formula 1, having the structure.

US Patent:

7276519, Oct 2, 2007

Filed:

May 14, 2004

Appl. No.:

10/845710

Inventors:

Diane Harris Boschelli - New City NY, US
Nan Zhang - Bayside NY, US
Ana Carolina Barrios Sosa - Scotch Plains NJ, US
Haris Durutlic - New Windsor NY, US
Biqi Wu - Nanuet NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/4365
C07D 495/06

US Classification:

514301, 546114

Abstract:

This invention provides compounds of Formula (1)–(1), II.

US Patent:

7285555, Oct 23, 2007

Filed:

Sep 24, 2004

Appl. No.:

10/950542

Inventors:

Nan Zhang - Bayside NY, US

Assignee:

Wyeth Holdings Corporation - Madison NJ

International Classification:

A61K 31/519
C07D 487/04
A61P 35/04

US Classification:

5142591, 544281

Abstract:

This invention relates to certain 6-aryl-7-halo-imidazo[1,2-a]pyrimidines or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals by promotion of microtubule polymerization. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof.

US Patent:

7507739, Mar 24, 2009

Filed:

Sep 24, 2004

Appl. No.:

10/950543

Inventors:

Nan Zhang - Bayside NY, US
Thai Nguyen - Fair Lawn NJ, US
Yanzhong Wu - Bronx NY, US
Wei Tong - Suffern NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 487/04
A61K 31/519
A61P 35/04

US Classification:

5142593, 544263

Abstract:

This invention relates to certain 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. The present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.