Nancy Harper

US Patent:

20170273932, Sep 28, 2017

Filed:

Aug 24, 2015

Appl. No.:

15/505308

Inventors:

- Boston MA, US
Nancy Harper - Taunton MA, US
David Dresback - Stonington CT, US
Thomas Crawford - Essex CT, US
Gary Elliott - Portland ME, US
Walter Lunsmann - Harvard MA, US
Grant Wilson - San Diego CA, US
Jose Casillas - Chula Vista CA, US

International Classification:

A61K 31/336
A61K 47/10
A61K 47/26
A61K 47/14
A61K 9/00
A61K 47/24
A61K 47/32
A61K 47/38
A61K 47/02
A61K 9/19
A61K 47/44

Abstract:

This disclosure features compositions (e.g., re-constitutable solids, such as lyophilized cakes; or liquid compositions, such as solutions or suspensions, e.g., reconstituted lyophilized cakes) that are suitable for subcutaneous administration. The compositions include a crystalline form (e.g., Form A) of 6-O-(4-dimethylaminoethoxy)cinnamoyl fumagillol, free base and one or more pharmaceutically acceptable excipients and/or one or more pharmaceutically acceptable carriers (e.g., one or more bulking agents; one or more dispersing agents; one or more buffers; one or more suspending agents; water, e.g., water for injection (“WFI”)).