Nancy Meade Gray

US Patent:

55611516, Oct 1, 1996

Filed:

Jan 4, 1995

Appl. No.:

8/368735

Inventors:

James W. Young - Palo Alto CA
Nancy M. Gray - Marlborough MA
William J. Wechter - Redlands CA

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A61K 3140

US Classification:

514411

Abstract:

Methods are disclosed utilizing optically pure R(-) etodolac for the treatment of pain, including but not limited to pain associated with toothaches, headaches, sprains, joint pain and surgical pain, for example dental pain and ophthalmic pain, while substantially reducing adverse effects which are associated with the administration of the racemic mixture of etodolac. The optically pure R(-) etodolac is also useful in treating pyrexia while substantially reducing the adverse effects associated with the administration of the racemic mixture of etodolac.

US Patent:

53310004, Jul 19, 1994

Filed:

Mar 1, 1993

Appl. No.:

8/024728

Inventors:

James W. Young - Palo Alto CA
Nancy M. Gray - Marlborough MA
William J. Wechter - Redlands CA

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A61K 3119

US Classification:

514570

Abstract:

Methods and compositions are disclosed utilizing optically pure R(-) ketoprofen for the treatment of pain including, but not limited to, pain associated with toothaches, headaches, sprains, joint pain and post-surgical pain, for example dental pain and ophthalmic pain, while substantially reducing adverse effects including, but not limited to, gastrointestinal, renal and hepatic toxicities, and leukopenia, which are associated with the administration of racemic ketoprofen. Optically pure R(-) ketoprofen is also useful in treating pyrexia while substantially reducing the adverse effects associated with the administration of racemic ketoprofen.