Nancy Beasley Levin

US Patent:

20120282279, Nov 8, 2012

Filed:

Nov 4, 2011

Appl. No.:

13/289533

Inventors:

Tapan Kanti Das - Ballwin MO, US
Tamara Shafer Hodge - Ballwin MO, US
Tetsuya Ishino - Boston MA, US
Nancy Jane Levin - Encinitas CA, US
Erin Kristan Parsons - University City MO, US
Bernard Norman Violand - Wildwood MO, US

Assignee:

COVX TECHNOLOGIES IRELAND LIMITED - County Dublin
PFIZER INC - New York NY

International Classification:

A61K 39/44
A61P 3/10
A61P 3/04
A61P 3/08
A61P 9/12
A61P 1/16
A61P 9/00
A61P 5/48
C07K 19/00
A61P 3/06

US Classification:

4241781, 5303911

Abstract:

The present invention provides a FGF21 molecule covalently attached to the combining site of an antibody via a linker, wherein the linker is covalently attached to the side chain of a linking residue within FGF21. Various uses of the compounds are provided, including methods to prevent or treat diabetes or diabetes-related conditions.

US Patent:

20130164310, Jun 27, 2013

Filed:

Dec 12, 2012

Appl. No.:

13/712873

Inventors:

PFIZER INC. - , US
Rory Francis Finn - Manchester MO, US
Jie Huang - San Diego CA, US
Olivier Alexandre Laurent - San Diego CA, US
Nancy Jane Levin - Encinitas CA, US
Nicholas Gary Luksha - North Andover MA, US
Joseph Patrick Martin, JR. - Wildwood MO, US
Haim Moskowitz - San Diego CA, US
Mark John Pozzo - Chesterfield MO, US
Gregory Allan Waszak - O'Fallon MO, US
Jin Xie - Ballwin MO, US

International Classification:

C12N 9/96

US Classification:

4241781, 435188

Abstract:

The present invention provides a composition of the formula: [FGF21-1Linker]-[Ab]-[2-Linker-Ex4]; wherein FGF21 is an FGF21 homologue; and Ex4 is an Exendin4 homologue; and Ab is an aldolase catalytic antibody or antigen binding portion thereof; and the 1linker is covalently attached to the side chain of a protein-linking residue in FGF21 and to a combining site of the antibody, and the 2linker is covalently attached to the side chain of a peptide-linking residue in Ex4 and to a combining site of the antibody, and wherein the first and second linker are the same or different. Various uses of the compounds are provided, including methods to prevent or treat diabetes or diabetes-related conditions.