Nancy J Levin

US Patent:

20060205660, Sep 14, 2006

Filed:

May 11, 2006

Appl. No.:

11/433186

Inventors:

Frederic Sauvage - Foster City CA, US
Nancy Levin - Newbury Park CA, US
Richard Vandlen - Hillsborough CA, US

International Classification:

A61K 38/17
C07K 14/705
C07H 21/04
C12P 21/06

US Classification:

514012000, 435069100, 435320100, 435325000, 530350000, 536023500

Abstract:

The present invention concerns long-half derivative of the obesity protein OB. The invention specifically concerns OB protein-immunoglobulin chimeras and polyethylene glycol (PEG)-OB derivatives, which have extended half-life as compared to the corresponding native OB proteins. The invention further relates to methods for appetite and/or weight reducion and for treating other physiological conditions by using the long half-life derivatives of OB.

US Patent:

6620413, Sep 16, 2003

Filed:

Dec 27, 1996

Appl. No.:

08/775066

Inventors:

Frederic DeSauvage - Foster City CA
Nancy Levin - Newbury Park CA
Richard Vandlen - Hillsborough CA

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 39395

US Classification:

4241781, 4241791, 514 2, 530350

Abstract:

The present invention concerns long-half derivative of the obesity protein OB. The invention specifically concerns OB protein-immunoglobulin chimeras and polyethylene glycol (PEG)-OB derivatives, which have extended half-life as compared to the corresponding native OB proteins. The invention further relates to methods for treating obesity by using the long half-life derivatives of OB.