Nancy C Mello

US Patent:

55524060, Sep 3, 1996

Filed:

Jun 17, 1994

Appl. No.:

8/261770

Inventors:

Jack H. Mendelson - Rockport MA
Nancy K. Mello - Rockport MA

Assignee:

The McLean Hospital Corporation - Belmont MA

International Classification:

A61K 3156
C07D48912

US Classification:

514279

Abstract:

A method for treating pain and brain perfusion abnormalities using mixed opiate agonist/antagonists is provided.

US Patent:

50753410, Dec 24, 1991

Filed:

Dec 1, 1989

Appl. No.:

7/441913

Inventors:

Jack H. Mendelson - Rockport MA
Nancy K. Mello - Rockport MA

Assignee:

The McLean Hospital Corporation - Belmont MA

International Classification:

A61K 3144

US Classification:

514282

Abstract:

Mixed opiate agonist/antagonists, particularly buprenorphine, is provided for the treatment of cocaine dependence and concurrent cocaine and opiate abuse and dependence.

US Patent:

58664270, Feb 2, 1999

Filed:

Jun 13, 1997

Appl. No.:

8/873896

Inventors:

Jack H. Mendelson - Rockport MA
Nancy K. Mello - Rockport MA
Tak-Ming Chiu - Belmont MA

Assignee:

The McLean Hospital Corporation - Belmont MA

International Classification:

G01N 3398
G01N 3348
G01N 3349

US Classification:

436 63

Abstract:

In the method of the invention, in vitro proton MRS is employed to determine the measurable ethanol concentrations in ethanol-treated erythrocyte samples of occasional and heavy drinkers. An erythrocyte to plasma ethanol concentration ratio is determined based upon the MRS measured erythrocyte concentration. Erythrocyte to plasma ethanol concentration ratios are significantly greater for heavy drinkers (a subset of alcohol tolerant individuals) as compared to the ratios calculated for occasional drinkers (non-tolerant individuals) when erythrocyte ethanol concentration is determined by MRS. Thus, the method of the present invention discriminates between alcohol tolerant individuals and alcohol non-tolerant individuals based upon the magnitude of the erythrocyte to plasma ethanol concentration ratio obtained according to the methods disclosed herein.