Nancy A Nicholson

US Patent:

20040106626, Jun 3, 2004

Filed:

Oct 3, 2002

Appl. No.:

10/263525

Inventors:

Michael South - St. Louis MO, US
Ronald Webber - St. Charles MO, US
Horng-Chih Huang - Chesterfield MO, US
Mihaly Toth - St. Louis MO, US
Alan Moormann - Weldon Springs MO, US
Jeffery Snyder - Manchester MO, US
Jeffrey Scholten - Chesterfield MO, US
Danny Garland - Ballwin MO, US
Melvin Rueppel - St. Louis MO, US
William Neumann - St. Louis MO, US
Scott Long - Ballwin MO, US
Wei Huang - Wildwood MO, US
John Trujillo - St. Peters MO, US
John Parlow - Arnold MO, US
Darin Jones - Ballwin MO, US
Brenda Case - St. Louis MO, US
Michael Hayes - St. Louis MO, US
Qingping Zeng - Thousand Oaks CA, US
Ricky Fenton - Collinsville IL, US
Carrie Kusturin - Kirkwood MO, US
Hayat Rahman - Belleville IL, US
Zaheer Abbas - Chesterfield MO, US
Kirby Sample - St. Louis MO, US
Barbara Schweitzer - St. Louis MO, US
Rhonda Wood - Rock Hill MO, US
Jim Szalony - Hammond IN, US
Osman Suleymanov - Arlington Heights IL, US
Anita Salyers - Palatine IL, US
Nancy Nicholson - Warrenville IL, US

Assignee:

Pharmacia Corporation

International Classification:

A61K031/4965
C 07D 4 3/02

US Classification:

514/255050, 514/255060, 544/405000, 544/407000

Abstract:

The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.