Natasja Brooijmans from Boston, MA, age 50

Resumes

Vice President

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Location:

215 1St St, Cambridge, MA 02142

Industry:

Pharmaceuticals

Work:

Blueprint Medicines - Cambridge, MA since May 2011
Senior Scientist
Novartis Institutes for BioMedical Research Mar 2010 - May 2011
Investigator III
Pfizer Pharmaceuticals Oct 2009 - Feb 2010
Principal Research Scientist
Wyeth Research - Pearl River, NY Jan 2009 - Oct 2009
Principal Research Scientist
Wyeth Research Jan 2006 - Dec 2008
Senior Research Scientist II

Education:

University of California, San Francisco 1999 - 2003
Ph.D., Chemistry & Chemical Biology University of Utrecht 1993 - 1998
M.Pharm., Pharmacy Columbia University in the City of New York
University of California, Berkeley - Walter A. Haas School of Business

Skills:

Computational Chemistry
Drug Design
Drug Discovery
Biochemistry
Medicinal Chemistry
Molecular Modeling
Drug Development
High Throughput Screening
Lead Change
Biophysics
Cheminformatics
Life Sciences
Pharmaceutical Industry
Virtual Screening
Adme
Biotechnology
Knime
Drug Metabolism

At Blueprint Medicines

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Position:

Senior Scientist at Blueprint Medicines

Location:

Greater Boston Area

Industry:

Pharmaceuticals

Work:

Education:

Skills:

Drug Discovery
Medicinal Chemistry
Drug Design
Computational Chemistry
Virtual Screening

Us Patents

3H-[1,2,3]Triazolo[4,5-D]Pyrimidine Compounds, Their Use As Mtor Kinase And Pi3 Kinase Inhibitors, And Their Syntheses
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US Patent:

20090181963, Jul 16, 2009
Filed:

Jan 15, 2009
Appl. No.:

12/354027
Inventors:

Christoph Martin Dehnhardt - New York NY, US
Aranapakam Mudumbai Venkatesan - Rego Park NY, US
Efren Guillermo Delos Santos - Nanuet NY, US
Zecheng Chen - New City NY, US
Osvaldo Dos Santos - Astoria NY, US
Natasja Brooijmans - New York NY, US
Arie Zask - New York NY, US
Jeroen Cunera Verheijen - Highland Mills NY, US
Assignee:

Wyeth - Madison NJ
International Classification:

A61K 31/5377
C07D 413/14
A61P 35/00
US Classification:

5142342, 544118
Abstract:

The invention relates to 3H-[1,2,3]triazolo[4,5-d]pyrimidine compounds of the Formula 1:or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

7H-Pyrrolo[2,3-H]Quinazoline Compounds, Their Use As Mtor Kinase And Pi3 Kinase Inhibitors, And Their Synthesis
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US Patent:

20090227575, Sep 10, 2009
Filed:

Mar 4, 2009
Appl. No.:

12/397590
Inventors:

Aranapakam Mudumbai Venkatesan - Rego Park NY, US
Zecheng Chen - New City NY, US
Osvaldo Dos Santos - Astoria NY, US
Natasja Brooijmans - New York NY, US
Ariamala Gopalsamy - Mahwah NJ, US
Assignee:

Wyeth - Madison NJ
International Classification:

A61K 31/5377
C07D 487/04
A61P 35/00
US Classification:

5142328, 544115
Abstract:

A 7H-pyrrolo[2,3-h]quinazoline compound of the formula Iwherein Ar, R, R, R, R, R, R, R, R, and n are as defined in the specification, and methods for making same.

3-Substituted-1H-Pyrrolo[2,3-B]Pyridine And 3-Substituted-1H-Pyrrolo[3,2-B]Pyridine Compounds, Their Use As Mtor Kinase And Pi3 Kinase Inhibitors, And Their Syntheses
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US Patent:

20090298820, Dec 3, 2009
Filed:

May 28, 2009
Appl. No.:

12/473658
Inventors:

Gary Harold Birnberg - Tuxedo Park NY, US
Gloria Jean MacEwan - Monroe NY, US
Matthew Gregory Bursavich - Salt Lake City UT, US
Sabrina Lombardi - New Haven CT, US
Nan Zhang - Bayside NY, US
Adam Matthew Gilbert - Congers NY, US
George Theordore Grosu - Pearl River NY, US
Natasja Brooijmans - New York NY, US
Thai Hiep Nguyen - Fair Lawn NJ, US
Assignee:

Wyeth - Madison NJ
International Classification:

A61K 31/437
A61K 31/5375
A61K 31/5377
A61K 31/496
C07D 471/04
A61P 35/00
C07D 498/08
A61P 29/00
A61P 17/00
A61P 19/00
US Classification:

5142305, 5142345, 51425304, 514300, 544105, 544127, 544362, 546113
Abstract:

The invention relates to 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula 1:

3-Substituted-1H-Indole Compounds, Their Use As Mtor Kinase And Pi3 Kinase Inhibitors, And Their Syntheses
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US Patent:

20090311217, Dec 17, 2009
Filed:

May 28, 2009
Appl. No.:

12/473605
Inventors:

Matthew Gregory Bursavich - Salt Lake City UT, US
Nan Zhang - Bayside NY, US
James Thomas Anderson - Hillsdale NJ, US
Thai Hiep Nguyen - Fair Lawn NJ, US
Sabrina Lombardi - New Haven CT, US
David Malwitz - Hopewell Junction NY, US
Natasja Brooijmans - New York NY, US
Derek Cecil Cole - New City NY, US
Adam Matthew Gilbert - Congers NY, US
Pawel Wojciech Nowak - Woodcliff Lake NJ, US
Kaapjoo Park - Congers NY, US
Sasmita Das - West Nyack NY, US
Aranapakam Mudumbai Venkatesan - Rego Park NY, US
Mercy Adufa Otteng - Pearl River NY, US
Gary Harold Birnberg - Tuxedo Park NY, US
Gloria Jean MacEwan - Monroe NY, US
Assignee:

Wyeth - Madison NJ
International Classification:

A61K 31/404
C07D 405/02
C07D 403/14
C07D 413/02
A61K 31/496
A61K 31/5377
A61K 38/21
A61K 39/395
A61P 35/00
US Classification:

424 856, 548454, 544373, 544121, 514414, 51425409, 5142352, 4241331
Abstract:

The invention relates to 3-substituted-1H-indole compounds of the Formula I:or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

4-Phenoxy-6-Aryl-1H-Pyrazolo[3,4-D]Pyrimidine And N-Aryl-6-Aryl-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine Compounds, Their Use As Mtor Kinase And Pi3 Kinase Inhibitors, And Their Syntheses
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US Patent:

20100015141, Jan 21, 2010
Filed:

Jul 21, 2009
Appl. No.:

12/506291
Inventors:

Matthew Gregory Bursavich - Salt Lake City UT, US
Pawel Wojciech Nowak - Woodcliff Lake NJ, US
David Malwitz - Hopewell Junction NY, US
Sabrina Lombardi - New Haven CT, US
Adam Matthew Gilbert - Congers NY, US
Nan Zhang - Bayside NY, US
James Thomas Anderson - Hillsdale NJ, US
Natasja Brooijmans - New York NY, US
Assignee:

Wyeth - Madison NJ
International Classification:

A61K 31/519
C07D 487/04
A61K 39/395
A61P 35/00
US Classification:

4241331, 544262, 5142621
Abstract:

The invention relates to 4,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidin-4-amine compounds, including 4-phenoxy-6-aryl-1H-pyrazolo[3,4-d]pyrimidine and N-aryl-6-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-amine compounds of the Formula I:or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

Imidazolopyrimidine Analogs And Their Use As Pi3 Kinase And Mtor Inhibitors
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US Patent:

20080233127, Sep 25, 2008
Filed:

Mar 7, 2008
Appl. No.:

12/044500
Inventors:

Matthew Gregory Bursavich - Sandy UT, US
Aranapakam Mudumbai Venkatesan - Rego Park NY, US
Pawel Wojciech Nowak - Montvale NJ, US
Sabrina Lombardi - New Haven CT, US
Adam Matthew Gilbert - Congers NY, US
Christoph Martin Denhardt - New York NY, US
Osvaldo Dos Santos - Astoria NY, US
Efren Guillermo Delos Santos - Nanuet NY, US
Natasja Brooijmans - New York NY, US
Zecheng Chen - New City NY, US
Jeroen Cunera Verheijen - Highland Mills NY, US
Joshua Kaplan - Nyack NY, US
Arie Zask - New York NY, US
Assignee:

Wyeth - Madison NJ
International Classification:

A61K 39/395
C07D 473/00
A61K 31/5377
A61P 35/04
A61P 3/00
A61P 1/00
A61P 29/00
A61P 19/00
A61K 31/52
US Classification:

4241451, 544264, 544122, 5142342, 5142631
Abstract:

The present invention relates to Imidazolopyrimidine Analogs, methods of making Imidazolopyrimidine Analogs, compositions comprising an Imidazolopyrimidine Analog, and methods for treating or preventing a PI3K-related disorder comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog. The invention also relates to methods for treating or preventing mTOR-related disorders comprising administering to a subject in need thereof an effective amount of an Imidazolopyrimidine Analog.

Egfr Inhibitors
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US Patent:

20230056541, Feb 23, 2023
Filed:

Oct 29, 2021
Appl. No.:

17/514457
Inventors:

- Cambridge MA, US
Thomas A. Dineen - Cambridge MA, US
Natasja Brooijmans - Cambridge MA, US
Jason D. Brubaker - Cambridge MA, US
Meredith Suzanne Eno - Cambridge MA, US
Joseph L. Kim - Cambridge MA, US
Emanuele Perola - Cambridge MA, US
Brett D. Williams - Cambridge MA, US
Douglas Wilson - Cambridge MA, US
Kevin J. Wilson - Cambridge MA, US
Christopher De Savi - Cambridge MA, US
International Classification:

C07D 401/14
C07D 471/04
C07D 491/048
C07D 471/08
C07D 498/08
C07D 519/00
C07D 491/107
C07D 491/113
Abstract:

The present disclosure provides a compound represented by structural formula (I): or a pharmaceutically acceptable salt thereof useful for treating a cancer.

Inhibitors Of The Fibroblast Growth Factor Receptor
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US Patent:

20190359682, Nov 28, 2019
Filed:

Dec 21, 2018
Appl. No.:

16/231184
Inventors:

- Cambridge MA, US
Natasja BROOIJMANS - Boston MA, US
Brian L. HODOUS - Arlington MA, US
Joseph L. KIM - Wayland MA, US
Chandrasekhar V. MIDUTURU - Cambridge MA, US
Assignee:

BLUEPRINT MEDICINES CORPORATION - Cambridge MA
International Classification:

C07K 14/71
A61K 31/519
A61K 31/517
A61K 31/4375
C07D 401/04
C07D 475/04
C07D 239/42
C07D 487/04
C07D 475/00
C07D 471/04
C07D 239/84
C07D 295/155
Abstract:

Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.

Natasja Brooijmans

Natasja Brooijmans Phones & Addresses

Resumes

Vice President

At Blueprint Medicines

Us Patents

3H-[1,2,3]Triazolo[4,5-D]Pyrimidine Compounds, Their Use As Mtor Kinase And Pi3 Kinase Inhibitors, And Their Syntheses

7H-Pyrrolo[2,3-H]Quinazoline Compounds, Their Use As Mtor Kinase And Pi3 Kinase Inhibitors, And Their Synthesis

3-Substituted-1H-Pyrrolo[2,3-B]Pyridine And 3-Substituted-1H-Pyrrolo[3,2-B]Pyridine Compounds, Their Use As Mtor Kinase And Pi3 Kinase Inhibitors, And Their Syntheses

3-Substituted-1H-Indole Compounds, Their Use As Mtor Kinase And Pi3 Kinase Inhibitors, And Their Syntheses

4-Phenoxy-6-Aryl-1H-Pyrazolo[3,4-D]Pyrimidine And N-Aryl-6-Aryl-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine Compounds, Their Use As Mtor Kinase And Pi3 Kinase Inhibitors, And Their Syntheses

Imidazolopyrimidine Analogs And Their Use As Pi3 Kinase And Mtor Inhibitors

Egfr Inhibitors

Inhibitors Of The Fibroblast Growth Factor Receptor

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