Nathan Daniel Wolfe

US Patent:

8541221, Sep 24, 2013

Filed:

Jul 1, 2010

Appl. No.:

12/829125

Inventors:

William M. Switzer - Stone Mountain GA, US
Walid Heneine - Atlanta GA, US
Thomas M. Folks - Helotes TX, US
Nathan D. Wolfe - Los Angeles CA, US
Donald S. Burke - Pittsburgh PA, US
Eitel Mpoudi Ngole - Yaoundé, CM

Assignee:

The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention - Washington DC
Johns Hopkins University - Baltimore MD

International Classification:

C12N 7/00
C12N 7/04

US Classification:

435236, 4352351, 930 10, 930220, 930221

Abstract:

Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.

US Patent:

20080292657, Nov 27, 2008

Filed:

Feb 24, 2007

Appl. No.:

11/678596

Inventors:

William M. Switzer - Stone Mountain GA, US
Walid Heneine - Atlanta GA, US
Thomas M. Folks - Helotes TX, US
Nathan D. Wolfe - Los Angeles CA, US
Donald S. Burke - Pittsburgh PA, US
Eitel Mpoudi-Ngole - Yaounde, CM

International Classification:

A61K 39/00
C12N 15/11
C12N 7/00
A61P 37/00
C12Q 1/70
C12N 15/00

US Classification:

4242041, 536 2372, 4352351, 4353201, 435 5

Abstract:

Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.

US Patent:

20100160420, Jun 24, 2010

Filed:

May 20, 2008

Appl. No.:

12/600995

Inventors:

William M. Switzer - Stone Mountain GA, US
Walid Heneine - Atlanta GA, US
Thomas M. Folks - Lithonia GA, US
Nathan D. Wolfe - Los Angeles CA, US
Donald S. Burke - Pittsburgh PA, US
David M. Sintasath - Atlanta GA, US

International Classification:

A61K 31/7088
C07H 21/00
C12N 15/74
C12N 5/10
C12N 7/01
C12N 9/48
C12N 9/10
C07K 14/00
C07K 16/00
C12N 9/00
C12Q 1/68
G01N 33/53
A61P 31/12
A61P 37/04

US Classification:

514 44 R, 536 231, 4353201, 435325, 4352351, 435212, 435193, 530300, 5303871, 5303913, 5303917, 435183, 435 6, 435 71

Abstract:

Disclosed are the simian T-cell lymphotropic virus type 3 subtype D (STLV-3 subtype D), isolated nucleic acid molecules encoding STLV-3 subtype D polypeptides, such as STLV-3 subtype D envelope, protease, polymerase, tax, rex, and capsid polypeptides, isolated polypeptides encoded by such nucleic acids. Methods are also disclosed for detecting STLV-3 subtype D, for example by detecting a STLV-3 subtype D nucleic acid or polypeptide in the sample. Accordingly, probes, primers, and antibodies for use in detecting STLV-3 subtype D nucleic acids or polypeptides are disclosed. Therapeutic compositions which included isolated nucleic acid molecules encoding a STLV-3 subtype D polypeptides or isolated polypeptides encoded by such nucleic acid molecules are also disclosed.

US Patent:

20140080121, Mar 20, 2014

Filed:

Sep 20, 2013

Appl. No.:

14/032914

Inventors:

Thomas M. Folks - Helotes TX, US
Nathan D. Wolfe - Los Angeles CA, US
Donald S. Burke - Pittsburgh PA, US
Eitel Mpoudi Ngole - Yaounde, CM

Assignee:

Johns Hopkins University - Baltimore MD
The Government of the United States of America as represented by the Secretary of the Department of - Atlanta GA

International Classification:

C12Q 1/70

US Classification:

435 5

Abstract:

Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.

US Patent:

20140186383, Jul 3, 2014

Filed:

Aug 29, 2013

Appl. No.:

14/013947

Inventors:

- Baltimore MD, US
- Atlanta GA, US
Thomas M. Folks - Helotes TX, US
Nathan D. Wolfe - Los Angeles CA, US
Donald S. Burke - Pittsburgh PA, US
David M. Sintasath - Atlanta GA, US

Assignee:

Johns Hopkins University - Baltimore MD
The Government of the U.S.A as Represented by the Secretary of the Department of He - Atlanta GA

International Classification:

C07K 14/005
G01N 33/569
C07K 16/10

US Classification:

4241871, 530350, 5303879, 5303913, 435188, 435 5

Abstract:

Disclosed are the simian T-cell lymphotropic virus type 3 subtype D (STLV-3 subtype D), isolated nucleic acid molecules encoding STLV-3 subtype D polypeptides, such as STLV-3 subtype D envelope, protease, polymerase, tax, rex, and capsid polypeptides, isolated polypeptides encoded by such nucleic acids. Methods are also disclosed for detecting STLV-3 subtype D, for example by detecting a STLV-3 subtype D nucleic acid or polypeptide in the sample. Accordingly, probes, primers, and antibodies for use in detecting STLV-3 subtype D nucleic acids or polypeptides are disclosed. Therapeutic compositions which include isolated nucleic acid molecules encoding a STLV-3 subtype D polypeptides or isolated polypeptides encoded by such nucleic acid molecules are also disclosed.