Neal A Scott

US Patent:

6355055, Mar 12, 2002

Filed:

Oct 21, 1997

Appl. No.:

08/967331

Inventors:

Ron Waksman - Atlanta GA
Neal A. Scott - Atlanta GA

Assignee:

Emory University - Atlanta GA

International Classification:

A61F 206

US Classification:

623 113, 623 139, 623 142, 623 144, 623 141, 600 36

Abstract:

An endovascular support device adapted for local delivery of a therapeutic agent and for minimizing the rate of restinosis having a cylindrical support body with an inside surface and an opposite outside surface, and at least one layer of pericardial tissue covering at least a portion of at least a selected one of the inside surface or the outside surface of the cylindrical support body. At least one therapeutic agent is disposed on a portion of the support device.

US Patent:

6475644, Nov 5, 2002

Filed:

Aug 31, 1999

Appl. No.:

09/386779

Inventors:

Janet M. Hampikian - Decatur GA
Neal A. Scott - Stone Mountain GA

Assignee:

Radiovascular Systems, L.L.C. - Atlanta GA

International Classification:

B23B 1500

US Classification:

428655, 106 112, 106 113, 106 115, 106 118, 106 121, 106 127, 205 80, 205170, 205181, 205187, 205188, 205191, 205197, 205261, 427 5, 427304, 427305, 427405, 427437, 428680, 428686, 428457, 428926, 428935, 428936, 604509, 606 7

Abstract:

Radioactive coating solutions and sol-gels, and corresponding methods for making a substrate radioactive by the application of the radioactive coating solutions and sol-gels thereto. The radioactive coating solution comprises at least one carrier metal and a radioisotope, which may be soluble or insoluble, and may further comprise a reducing agent. The radioactive sol-gel comprises at least one metal alkoxide and a radioisotope, which may be soluble or insoluble. Methods of making a substrate radioactive by coating with radioactive coating solutions or sol-gels are also disclosed, including electrodeposition, electroless deposition, spin coating and dip coating. In a particular embodiment, the radioactive coating formed by the method is a composite coating. Radioactive substrates are also disclosed, comprising a substrate and one or more radioactive coatings, which coatings may be the same or different. Suitable substrates include medical devices, such as catheters, stents, brachytherapy devices and guidewires, or components thereof Medical devices capable of generating asymmetric, or targeted, radiation fields are also disclosed.

US Patent:

7292885, Nov 6, 2007

Filed:

Apr 30, 2002

Appl. No.:

10/135709

Inventors:

Neal Scott - Houston TX, US
Jerome Segal - Chevy Chase CA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61N 1/30
A61M 29/00

US Classification:

604 21, 604104

Abstract:

A mechanical dilatation and medicament delivery device for enlarging a flow passage of a vessel by dilating and delivering a liposome or micelle-encapsulated therapeutic agent or medicament to an obstruction in the vessel. The present invention comprises a substantially cylindrically shaped expansion member and includes a means engaged to the expansion member for altering the distance between the proximal end and the distal end of the expansion member thereby transforming the expansion member between a diametrically contracted configuration to diametrically expanded configuration. A liposome or micelle-encapsulated therapeutic agent or medicament is coated on either the expansion member, or incorporated into a substrate coated on the expansion member.

US Patent:

7488313, Feb 10, 2009

Filed:

Nov 29, 2001

Appl. No.:

09/997855

Inventors:

Jerome Segal - Chevy Chase MD, US
Neal Scott - Houston TX, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61M 31/00

US Classification:

604509

Abstract:

A mechanical dilatation and medicament delivery device for enlarging a flow passage of a vessel by dilating and delivering a therapeutic agent or medicament to an obstruction in the vessel. The present invention comprises a substantially cylindrically shaped expansion member and includes a means engaged to the expansion member for altering the distance between the proximal end and the distal end of the expansion member thereby transforming the expansion member between a diametrically contracted configuration to diametrically expanded configuration. A therapeutic agent or medicament is coated on either the expansion member, or incorporated into a substrate coated on the expansion member. The present method comprises the steps of advancing the coated expansion member to the obstruction in a vessel and applying opposed forces on said expansion member in an axial direction to move the expansion member to an expanded configuration wherein the expansion member dilates the obstruction and the expansion member either passively or actively delivers a therapeutic agent or medicament to the obstruction.

US Patent:

7488314, Feb 10, 2009

Filed:

Sep 27, 2004

Appl. No.:

10/950606

Inventors:

Jerome Segal - Chevy Chase MD, US
Neal Scott - Houston TX, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61M 31/00

US Classification:

604509

Abstract:

The present method comprises the steps of advancing the coated expansion member to the obstruction in a vessel and applying opposed forces on said expansion member in an axial direction to move the expansion member to an expanded configuration wherein the expansion member dilates the obstruction and the expansion member either passively or actively delivers a therapeutic agent or medicament to the obstruction.

US Patent:

7517342, Apr 14, 2009

Filed:

Apr 29, 2003

Appl. No.:

10/425170

Inventors:

Neal Scott - Mountain View CA, US
Jerome Segal - Mountain View CA, US
Terry L. Burkoth - Palo Alto CA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61B 17/20

US Classification:

604501, 604 20

Abstract:

The present invention relates to a catheter with an expandable distal end for delivering one or more medicaments. The catheter is manufactured with materials of construction that allow the transfer of electrical energy from the proximal end of the catheter to the distal expandable end. The catheter also has a means for controlling or manipulating the expandable distal end to expand and contract into various configurations. The distal end of the catheter is processed by a specific method of manufacturing whereby the expandable distal end is coated with one or more layers of a hydrogel copolymer wherein at least one layer of which coating encapsulates one or more medicaments and zero or more charged carriers to facilitate the electrophoretic and electro-osmostic mobilities of the medicaments.

US Patent:

7519418, Apr 14, 2009

Filed:

Jun 10, 2004

Appl. No.:

10/865222

Inventors:

Neal Scott - Houston TX, US
Jerome Segal - Chevy Chase CA, US

Assignee:

Boston Scientific Scimed, Inc. - Maple Grove MN

International Classification:

A61N 1/30

US Classification:

604 20, 604 9601

Abstract:

An apparatus for delivering a medicament, such as a liposome or micelle-encapsulated therapeutic agent or medicament, to an obstruction within a vascular segment or a body passageway. The apparatus may include a substantially cylindrically shaped expansion member. A distance between the proximal and distal ends of the expansion member may be altered to transform the expansion member between a diametrically contracted configuration to a diametrically expanded configuration. The liposome or micelle-encapsulated therapeutic agent or medicament can be coated on the expansion member and/or incorporated into a substrate coated on the expansion member.

US Patent:

20030092957, May 15, 2003

Filed:

Apr 2, 2002

Appl. No.:

10/112764

Inventors:

Neal Scott - Stone Mountain GA, US
Janet Hampikian - Decatur GA, US

International Classification:

C23C018/00
C23C020/00
A61N005/00

US Classification:

600/003000, 428/457000, 428/680000, 428/686000, 428/926000, 428/655000, 106/001260, 427/405000

Abstract:

The present invention is directed to a brachytherapy device comprising a substrate comprising at least one radioactive coating layer formed thereon. The radioactive coating layer has a total radioactivity that varies in at least one dimension of the device. Methods of making radioactive coatings, such as electrochemical deposition, electroless deposition and sol-gel are also disclosed. Suitable substrates include medical devices, such as catheters, stents, brachytherapy devices and guidewires, or components thereof. The disclosed methods produce medical devices capable of generating asymmetric, or targeted, radiation fields that correspond to the morphology of a tumor. Methods of using these devices to treat cancer of the breast, brain, prostate, uterine, head and neck are also disclosed.