Nebojsa J Duric

US Patent:

8376946, Feb 19, 2013

Filed:

May 16, 2003

Appl. No.:

10/440427

Inventors:

Peter J. Littrup - Bloomfield Hills MI, US
Nebojsa Duric - Albuquerque NM, US
Earle Holsapple, III - Grosse Pointe Farms MI, US

Assignee:

Barbara Ann Karamanos Cancer Institute - Detroit MI

International Classification:

A61B 8/00

US Classification:

600437, 600438, 600439, 600485, 601 2, 601 3, 606 28, 606 41

Abstract:

A method for treating a medical pathology includes receiving a first set of acoustic radiation scattered by a volume of tissue containing at least a portion of the medical pathology and thereafter, changing a temperature of the volume of tissue. The method also includes thereafter, receiving a second set of acoustic radiation scattered by the volume of tissue and localizing the portion of the medical pathology from the first and second sets of received acoustic radiation. Localizing the portion of the medical pathology comprises identifying the medical pathology from differences in the first and second sets of received acoustic radiation resulting from the change in temperature. The method also includes insonifying the portion of the medical pathology with sufficient energy to damage the portion of the medical pathology.

US Patent:

20040122325, Jun 24, 2004

Filed:

Dec 18, 2002

Appl. No.:

10/323467

Inventors:

David Chambers - Livermore CA, US
Jeffrey Mast - Loveland CO, US
Stephen Azevedo - Livermore CA, US
Frank Wuebbeling - Billerbeck, DE
Frank Natterer - Muenster, DE
Nebojsa Duric - Albuquerque NM, US
Peter Littrup - Bloomfield MI, US
Earle Holsapple - Grosse Pointe Farms MI, US

Assignee:

Barbara Ann Karmanos Cancer Institute - Detroit MI

International Classification:

A61B008/14

US Classification:

600/467000

Abstract:

A method and apparatus are provided for investigating tissue in which acoustic data are derived from scattering a plurality of pulsed spherical or cylindrical acoustic waves from a plurality of transmission elements through the tissue to a plurality of receiving elements. The acoustic data, which include a mix of reflected and transmitted acoustic waves, are received and digitized, and a representation of a portion of the tissue is generated from the digitized acoustic data.

US Patent:

20080275344, Nov 6, 2008

Filed:

May 5, 2008

Appl. No.:

12/115174

Inventors:

Nebojsa Duric - Bloomfield Hills MI, US
Peter J. Littrup - Bloomfield Hills MI, US

Assignee:

Barbara Ann Karmanos Cancer Institute - Detroit MI

International Classification:

A61B 8/00

US Classification:

600442

Abstract:

A method for categorizing whole-breast density is disclosed. The method includes the steps of exposing breast tissue to an acoustic signal; measuring a distribution of an acoustic parameter by analyzing the acoustic signal; and obtaining a measure of whole-breast density from said measuring step. An apparatus is also disclosed.

US Patent:

20110201928, Aug 18, 2011

Filed:

Feb 14, 2011

Appl. No.:

13/027036

Inventors:

Nebojsa Duric - Bloomfield Hills MI, US
Peter John Littrup - Bloomfield Hills MI, US

International Classification:

A61B 8/00

US Classification:

600438

Abstract:

A method of characterizing the pathological response of tissue to a treatment plan, including: obtaining a set of sequential morphology renderings of the tissue, wherein each rendering corresponds to a particular point in time during the treatment plan; generating a set of representative values of a biomechanical property of the tissue for the set of renderings, wherein each representative value is based on a corresponding rendering; determining a trend of the biomechanical property based on the set of representative values; and predicting response of the tissue to the treatment plan based on the trend of the biomechanical property.

US Patent:

20110201932, Aug 18, 2011

Filed:

Feb 14, 2011

Appl. No.:

13/027070

Inventors:

Nebojsa Duric - Bloomfield Hills MI, US
Peter John Littrup - Bloomfield Hills MI, US

International Classification:

A61B 8/14

US Classification:

600443

Abstract:

A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.

US Patent:

20130041261, Feb 14, 2013

Filed:

Aug 3, 2012

Appl. No.:

13/566778

Inventors:

Cuiping Li - Troy MI, US
Nebojsa Duric - Bloomfield Hills MI, US

International Classification:

A61B 8/15

US Classification:

600442, 600447

Abstract:

The method of one embodiment for multi-grid tomographic inversion tissue imaging comprises receiving acoustic waveform data characterizing a volume of tissue, determining and refining models of the distributions of a first and second acoustomechanical parameter within the volume of tissue using a series of grids with progressively finer discretization levels, and generating an image based on at least one of the refined models of the first and second acoustomechanical parameters. The system of one embodiment for multi-grid tomographic inversion tissue imaging comprises ultrasound emitters configured to surround and emit acoustic waveforms toward a volume of tissue, ultrasound receivers configured to surround tissue and receive acoustic waveforms, and a processor configured to determine and refine models of the distributions of a first and second acoustomechanical parameter within a volume of tissue, and generate an image based on at least one of the refined models of the first and second acoustomechanical parameters.

US Patent:

20130204137, Aug 8, 2013

Filed:

Feb 1, 2013

Appl. No.:

13/756864

Inventors:

Cuiping Li - Troy MI, US
Nebojsa Duric - Bloomfield Hills MI, US

Assignee:

DELPHINUS MEDICAL TECHNOLOGIES, INC. - Plymouth MI

International Classification:

A61B 8/15

US Classification:

600448

Abstract:

A method and system for denoising acoustic travel times and imaging a volume of tissue comprising receiving a dataset representative of acoustic waveforms originating from an array of ultrasound emitters and received with an array of ultrasound receivers; for each ultrasound emitter in the array of ultrasound emitters, forming an empirical relative travel time matrix, from the dataset, including a set of relative empirical travel times, each relative empirical travel time corresponding to a pair of ultrasound receivers receiving an acoustic waveform, generating a denoised empirical relative travel time matrix, and extracting a set of denoised absolute travel times from the denoised empirical relative travel time matrix; and rendering an image of the volume of tissue based on an acoustomechanical parameter and the set of denoised absolute travel times corresponding to each ultrasound emitter in the array of ultrasound emitters.

US Patent:

20130303895, Nov 14, 2013

Filed:

May 14, 2013

Appl. No.:

13/894202

Inventors:

Nebojsa Duric - Bloomfield Hills MI, US
Gerrit Lee Littrup - East Lansing MI, US

Assignee:

Delphinus Medical Technologies, Inc. - Plymouth MI

International Classification:

A61B 19/00

US Classification:

600424

Abstract:

A system and method for performing an image-guided biopsy of a target mass of a volume of tissue comprising: a transducer array comprising a set of ultrasound emitters and a set of ultrasound receivers configured to generate a set of acoustic data based upon acoustic waveforms received from the volume of tissue, wherein the transducer array is configured to enable determination of a location of the target mass based on the set of acoustic data; a base proximate to the transducer array; a fixation plate coupled to the base and cooperating with the base and the transducer array to at least partially define an adjustable receiving space configured to receive the volume of tissue; and a guiding module coupled to the base and comprising an aperture configured to align a biopsy tool with the location of the target mass.