Nehal D Shah

US Patent:

20150291647, Oct 15, 2015

Filed:

Oct 24, 2014

Appl. No.:

14/522905

Inventors:

- Oakland CA, US
Aparna Baranwal - Cerritos CA, US
Nehal Mahendra Shah - Irvine CA, US

International Classification:

C07H 15/26
C07C 215/16
A61K 51/04
C07C 245/08
C07D 471/08
C07C 213/02
C07D 207/09
C07D 277/66

Abstract:

Various compositions and methods for Quasi-Amadori products and derivatives thereof are contemplated in which a halogenated carbohydrate is reacted with a primary amino group of an affinity ligand. In especially preferred aspects, the Quasi-Amadori product is formed from 2-fluorodeoxyglucose and an affinity moiety that preferentially or selectively binds to a neural cell or neural structure. Where contemplated compounds include F, PET imaging using compounds presented herein is especially preferred.