Neil K Cook

US Patent:

8372654, Feb 12, 2013

Filed:

Jun 12, 2001

Appl. No.:

10/311108

Inventors:

Neil Cook - Dover MA, US
Albie Santos - Cardiff, GB
Nigel Bosworth - Cardiff, GB
Jan Wolber - Cardiff, GB
Mike Looker - Cardiff, GB
Peter Knox - Wokingham, GB
Jan Jenrik Ardenkjaer-Larsen - Malmo, SE
Klaes Golman - Malmo, SE

Assignee:

GE Healthcare Limited - Buckinghamshire

International Classification:

G01N 1/00

US Classification:

436174, 600410, 324307, 324309, 436173, 424 93

Abstract:

The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarization methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.

US Patent:

20040018579, Jan 29, 2004

Filed:

Jul 31, 2003

Appl. No.:

10/398438

Inventors:

Neil Cook - Dover MA, US

International Classification:

C12Q001/37
C07K014/47
C07K007/08

US Classification:

435/023000, 530/324000

Abstract:

Disclosed is a peptide chain containing one or more dye molecules covalently bonded thereto, characterised in that at least one dye molecule is interposed in the amino sequence forming the peptide chain such that there is at least one amino acid covalently linked to and on each side of the said at least one dye molecule. Also disclosed is an assay method employing the dye-labelled compounds of the invention.

US Patent:

20110295764, Dec 1, 2011

Filed:

May 27, 2010

Appl. No.:

12/788456

Inventors:

Neil Cook - Cambridge MA, US
Raymond Ferrara - Concord MA, US

International Classification:

G06Q 10/00

US Classification:

705348

Abstract:

Generating a product layout includes obtaining attributes of a retail location; correlating the attributes of the retail location to information relating to a product in order to determine whether the product is appropriate for the retail location; and if the product is appropriate for the retail location, generating a layout of the product within the retail location relative to like products according to one or more predefined rules.