Neil S Goldstein

US Patent:

6365157, Apr 2, 2002

Filed:

Sep 22, 1999

Appl. No.:

09/401163

Inventors:

Patricia Rockwell - West Readding CT
Neil I. Goldstein - Maplewood NJ

Assignee:

ImClone Systems, Inc. - New York NY

International Classification:

A01N 3718

US Classification:

4241561, 4241381, 4241431, 514 2, 435330, 435334

Abstract:

Monoclonal antibodies that specifically bind to an extracellular domain of a flt-1 receptor and neutralize activation of the receptor are provided. In vitro and in vivo methods of using these antibodies are also provided.

US Patent:

6413717, Jul 2, 2002

Filed:

Mar 18, 1998

Appl. No.:

09/040981

Inventors:

Yilong Sun - Fort Lee NJ
Paul B. Fisher - Scarsdale NY
Neil I. Goldstein - Maplewood NJ

Assignee:

Corixa Corporation - Seattle WA

International Classification:

C12Q 168

US Classification:

435 6, 435 912

Abstract:

Methods are provided for identifying agents that modulate the expression of genes, such as genes encoding tumor suppressor or tumor-promoting proteins. The methods generally comprise screening candidate agents for the ability to enhance expression of a tumor suppressor gene, such as mda-7, or for the ability to inhibit expression of a tumor-promoting gene within a cell. Modulating agents may be used, for example, within anti-cancer therapies.

US Patent:

7060808, Jun 13, 2006

Filed:

Jun 7, 1996

Appl. No.:

08/973065

Inventors:

Neil I. Goldstein - Maplewood NJ, US
Nicholas A. Giorgio - New York NY, US
Steven Tarran Jones - Radlett, GB
Jose William Saldanha - Enfield, GB

Assignee:

ImClone Systems Incorporated - New York NY

International Classification:

C07H 21/04

US Classification:

536 231, 536 2353, 5303873, 53038885, 435 691, 435 696, 435325, 4352523

Abstract:

A nucleic acid is provided which encodes a humanized antibody or fragment thereof, which encodes a protein which binds to human EGF-receptor. Monoclonal antibody 225 is the complementary determining region (CDR) donor.

US Patent:

20030219821, Nov 27, 2003

Filed:

May 6, 2002

Appl. No.:

10/139732

Inventors:

Paul Fisher - Scarsdale NY, US
Neil Goldstein - Maplewood NJ, US

International Classification:

G01N033/53
C07H021/04
C12P021/02
C12N005/06
C07K016/30

US Classification:

435/007100, 435/069100, 435/326000, 435/320100, 530/388800, 536/023530

Abstract:

This invention provides a method for preparing antibodies directed against a protein associated with a cancer, comprising the steps of: (a) transfecting non-tumorigenic cells with a cDNA library comprising cDNA molecules derived from mRNA of cancer cells; (b) masking the transfected cells with antibodies raised against non-tumorigenic cells transfected with a cDNA library derived from normal cells; and (c) generating antibodies against the masked cells, and thereby generating antibodies directed against a protein associated with a cancer.

US Patent:

20030224001, Dec 4, 2003

Filed:

Feb 25, 2003

Appl. No.:

10/374600

Inventors:

Neil Goldstein - Maplewood NJ, US
Nicholas Giorgio - New York NY, US
Steven Jones - Radlett, GB
Jose Saldanha - Enfield, GB

International Classification:

A61K039/395
C07H021/04
C07K016/30
C07K016/46

US Classification:

424/178100, 530/388800, 530/391100, 536/023530

Abstract:

Chimerized and humanized versions of anti EGF receptor antibody 225 and fragments thereof for treatment of tumors.

US Patent:

20040006212, Jan 8, 2004

Filed:

Feb 25, 2003

Appl. No.:

10/374531

Inventors:

Neil Goldstein - Maplewood NJ, US
Nicholas Giorgio - New York NY, US
Steven Jones - Radlett, GB
Jose Saldanha - Enfield, GB

International Classification:

C07K016/30

US Classification:

530/387100, 530/391100

Abstract:

Chimerized and humanized versions of anti EGF receptor antibody 225 and fragments thereof for treatment of tumors.

US Patent:

20070116707, May 24, 2007

Filed:

Jun 13, 2006

Appl. No.:

11/453345

Inventors:

Neil Goldstein - Maplewood NJ, US
Nicholas Giorgio - New York NY, US
Steven Jones - Radlett, GB
Jose Saldanha - Enfield, GB

International Classification:

A61K 39/395
C07H 21/04
C12P 21/06
C12N 5/06
C07K 16/30
C07K 16/46
A61K 33/24

US Classification:

424155100, 424178100, 424649000, 530388800, 530391100, 536023530, 435069100, 435338000, 435320100

Abstract:

Chimerized and humanized versions of anti EGF receptor antibody 225 and fragments thereof for treatment of tumors.

US Patent:

20090099339, Apr 16, 2009

Filed:

Jul 9, 2008

Appl. No.:

12/170080

Inventors:

Neil I. Goldstein - Maplewood NJ, US
Nicholas A. Giorgio - New York NY, US
Steven Tarran Jones - Radlett, GB
Jose William Saldanha - Enfield, GB

Assignee:

ImClone Systems Incorporated - New York NY

International Classification:

C07K 16/18

US Classification:

5303871, 5303917

Abstract:

Chimerized and humanized versions of anti EGF receptor antibody 225 and fragments thereof for treatment of tumors.