Neil F Robbins

US Patent:

20040029264, Feb 12, 2004

Filed:

Aug 8, 2002

Appl. No.:

10/214324

Inventors:

Neil Robbins - Cary NC, US

International Classification:

C12N005/00
C12C001/15
C12C007/06

US Classification:

435/291600

Abstract:

The invention provides an advanced roller bottle system for cell culture that efficiently, continually, and automatically replenishes spent media with fresh media. The roller bottle system optimizes media use by removing spent media in response to a predetermined condition change and replenishing the spent media with fresh.

US Patent:

20060110822, May 25, 2006

Filed:

Sep 16, 2005

Appl. No.:

11/227489

Inventors:

Neil Robbins - Cary NC, US
Jon Rowley - Ann Arbor MI, US
Mark Quinto - Delran NJ, US
Abel Hastings - Durham NC, US
Bryan Towns - Union Bridge MD, US
Bradley Snodgrass - Watertown MA, US

International Classification:

C12M 3/00

US Classification:

435289100, 435305200, 435293100, 435299200

Abstract:

A bioreactor system comprising a multi-well platform including an array of bioreactor units. The bioreactor system comprises a perfusion unit and a fluid source unit fluidly interconnected by a pumping unit. The perfusion unit comprises a multi-well plate including a plurality of main chambers configured to house or contain a cell culture and in each bioreactor unit an independent cell study or experiment may be performed.

US Patent:

20060122104, Jun 8, 2006

Filed:

May 22, 2003

Appl. No.:

10/515421

Inventors:

Sharon Presnell - Raleigh NC, US
Mohammad Heidaran - Cary NC, US
Perry Haaland - Chapel Hill NC, US
Neil Robbins - Cary NC, US
David Scharp - Viejo CA, US
Paul Latta - Irvine CA, US
Margaret Coutts - Irvine CA, US
Catherine McIntyre - Aliso Viejo CA, US

International Classification:

C12N 5/08
A61K 38/18

US Classification:

514012000, 435370000

Abstract:

This invention relates, e.g., to a method for expanding mammalian acinar cells, comprising culturing the cells in a cell culture system comprising a cell culture medium and a cell attachment surface, under conditions wherein the acinar cells undergo a 3-4 fold expansion together with transdifferentiation into a modified cell phenotype (IP cells) showing characteristics of acinar cells and liver cells. The invention also relates to a method for transforming these IP cells to insulin-producing cells in vitro, comprising culturing the cells in a novel, defined medium. Also disclosed are suitable culture media for performing these methods, isolated cells having the phenotype of IP cells and/or produced by these methods, and kits for performing the methods.

US Patent:

20070082390, Apr 12, 2007

Filed:

Sep 18, 2006

Appl. No.:

11/532688

Inventors:

Abel Z. Hastings - Durham NC, US
Neil Robbins - Cary NC, US

International Classification:

C12M 1/22
C12M 1/34

US Classification:

435305200, 435297500, 435288400, 435299100

Abstract:

A scaffold handling system comprising a multi-well carrier including an array of well units wherein, in each well unit, an independent scaffold or tissue slice may be held and a biological experiment may be performed. The carrier may include any number of well units. In operation, the scaffold handling system is configured and dimensioned to mate with a multi-well plate.

US Patent:

20070092861, Apr 26, 2007

Filed:

Sep 10, 2004

Appl. No.:

10/570702

Inventors:

Richard Guarino - Holly Springs NC, US
Sharon Presnell - Raleigh NC, US
Andrea Liebmann-Vinson - Wake Forest NC, US
Mohammed Heidaran - Chatham NC, US
John Hemperly - Apex NC, US
Stewart Jurgensen - Raliegh NC, US
Ronald Laethem - Cary NC, US
Neil Robbins - Cary NC, US

International Classification:

C12Q 1/00
C12N 5/08

US Classification:

435004000, 435370000

Abstract:

Surfaces useful for cell culture comprise a support to which is bound a CAR material, and, bound to the CAR material, an ECM protein, or a biologically active fragment or variant thereof such as elastin, fibronectin, vitronectin, lamninin, collagen I, collagen III, collagen IV, and collagen VI. Also, optionally present on the surface is an active factor, preferably a polycationic polymer or a biologically active fragment or variant thereof, such as polyethyleneimine (PEI), poly-D-lysine (PDL), poly-L-lysine (PLL), poly-D-ornithine (PDO) or poly-L-ornithine (PLO). This surface is used in cell culture to promote cell attachment, survival, maintenance of function, and/or proliferation of primary liver cells. The invention also relates to methods utilizing this surface, such as methods for attachment, survival, maintenance of function, and/or proliferation of cells. Further disclosed is the use of the surface in cell culture with serum-free medium. Methods of screening using the surface of the invention are also disclosed.

US Patent:

20130330364, Dec 12, 2013

Filed:

Nov 10, 2011

Appl. No.:

13/883433

Inventors:

Joydeep Basu - Winston-Salem NC, US
Richard Payne - Winston-Salem NC, US
Neil F. Robbins - Winston-Salem NC, US
Oluwatoyin A. Knight - Winston-Salem NC, US
Deepak Jain - Winston-Salem NC, US
Craig R. Halberstadt - Winston-Salem NC, US
Monica A. Serban - Winston-Salem NC, US

Assignee:

TENGION, INC. - Winston-Salem NC

International Classification:

A61K 35/22
A61K 45/06

US Classification:

4241841, 424 937

Abstract:

The present invention concerns therapeutic formulations containing active agents, such bioactive cell populations, and methods of making and using the same.

US Patent:

20170368102, Dec 28, 2017

Filed:

Jul 6, 2017

Appl. No.:

15/643145

Inventors:

- George Town, KY
Richard Payne - Winston-Salem NC, US
Neil F. Robbins - Winston-Salem NC, US
Oluwatoyin A. Knight - Winston-Salem NC, US
Deepak Jain - Winston-Salem NC, US
Craig R. Halberstadt - Winston-Salem NC, US
Monica A. Serban - Winston-Salem NC, US

International Classification:

A61K 35/22
A61L 27/22
A61K 45/06
A61L 27/54

Abstract:

The present invention concerns therapeutic formulations containing active agents, such bioactive cell populations, and methods of making and using the same.

US Patent:

20150030657, Jan 29, 2015

Filed:

May 3, 2011

Appl. No.:

13/696051

Inventors:

John W. Ludlow - Carrboro NC, US
Manuel J. Jayo - Winston-Salem NC, US
Joydeep Basu - Winston-Salem NC, US
Timothy A. Bertram - Winston-Salem NC, US
Christopher W. Genheimer - Colfax NC, US
Kelly I. Guthrie - Winston-Salem NC, US
Roger M. Ilagan - Burlington NC, US
Deepak Jain - Winston-Salem NC, US
Oluwatoyin A. Knight - Winston-Salem NC, US
Richard Payne - Winston-Salem NC, US
Sarah F. Quinlan - Clemmons NC, US
H. Scott Rapoport - Sopelana Vizkaya, ES
Namrata D. Sangha - Winston-Salem NC, US
Jacob E. Shokes - Winston-Salem NC, US
Teresa B. Burnette - High Point NC, US
Sarah A. Boyd - Mooresville NC, US
Craig R. Halberstadt - Clemmons NC, US
Dominic M. Justewicz - Winston-Salem NC, US
Elias A. Rivera - Oak Ridge NC, US
Wendy Sharp - Winston-Salem NC, US
Neil F. Robbins - Blue Ash OH, US

Assignee:

TENGION, INC. - Winston-Salem NC

International Classification:

A61K 35/34

US Classification:

424424, 424 937

Abstract:

The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.