Ngoc Hoang Do

US Patent:

7687075, Mar 30, 2010

Filed:

Nov 16, 2004

Appl. No.:

10/988693

Inventors:

Stephen Skiendzielewski - Norristown PA, US
Martin Rose - Bethesda MD, US
Ngoc Do - Bel Air MD, US

Assignee:

Salix Pharmaceuticals, Ltd. - Morrisville NC

International Classification:

A61K 33/42
A61K 9/20
A61K 31/66

US Classification:

424606, 424464, 514 75

Abstract:

This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as polyethylene glycol. Further, this invention relates to methods of using the colonic purgative compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time improving the quality of bowel cleansing. The formulations and methods of this invention are particularly useful to cleanse the bowel prior to diagnostic and surgical procedures and can also be employed in lower dosages as a laxative to promote elimination and/or to relieve constipation.

US Patent:

7718197, May 18, 2010

Filed:

Mar 13, 2008

Appl. No.:

12/075772

Inventors:

Stephen Skiendzielewski - Norristown PA, US
Martin Rose - Bethesda MD, US
Ngoc Do - Bel Air MD, US

Assignee:

Salix Pharmaceuticals, Ltd. - Morrisville NC

International Classification:

A61K 33/42
A61K 9/20
A61K 31/66

US Classification:

424606, 424464, 514 75

Abstract:

This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as polyethylene glycol. Further, this invention relates to methods of using the colonic purgative compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time improving the quality of bowel cleansing. The formulations and methods of this invention are particularly useful to cleanse the bowel prior to diagnostic and surgical procedures and can also be employed in lower dosages as a laxative to promote elimination and/or to relieve constipation.

US Patent:

8110223, Feb 7, 2012

Filed:

Dec 31, 2003

Appl. No.:

10/749339

Inventors:

Larry Augsburger - Severna Park MD, US
Ngoc Do - Bel Air MD, US
Min Michael He - Ellicott City MD, US
Cheng Der Tony Yu - Baltimore MD, US

Assignee:

University of Maryland, Baltimore - Baltimore MD

International Classification:

A61K 9/14
A61K 9/50

US Classification:

424489, 424490, 424494, 424498

Abstract:

Novel methods for making dosages form comprising a cushioning component. The methods of the present invention provides dosage forms which can be compressed to form compressed dosage forms that are substantially uniform in composition and robust and exhibit reduced friability. The invention also relates to methods for making fast-disintegrating dosage forms.

US Patent:

8507009, Aug 13, 2013

Filed:

Jan 20, 2010

Appl. No.:

12/690384

Inventors:

Stephen Skiendzielewski - Norristown PA, US
Martin Rose - Bethesda MD, US
Ngoc Do - Bel Air MD, US

Assignee:

Salix Pharmaceuticals, Inc. - Raleigh NC

International Classification:

A61K 33/42
A61K 9/46
A61K 31/66

US Classification:

424606, 424466, 514 75

Abstract:

This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as polyethylene glycol. Further, this invention relates to methods of using the colonic purgative compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time improving the quality of bowel cleansing. The formulations and methods of this invention are particularly useful to cleanse the bowel prior to diagnostic and surgical procedures and can also be employed in lower dosages as a laxative to promote elimination and/or to relieve constipation.

US Patent:

20040161459, Aug 19, 2004

Filed:

Aug 1, 2003

Appl. No.:

10/633445

Inventors:

Ngoc Do - Bel Air MD, US
Cheng Der Yu - Baltimore MD, US
Larry Augsburger - Severna Park MD, US

International Classification:

A61K009/20
D04H001/00

US Classification:

424/465000, 264/109000

Abstract:

The current invention relies on a process already provided in great detail in U.S. Pat. No. 60/437,507 and an associated CIP filed on May 23, 2003 and hereby incorporated by reference. However, it was noted during additional studies that if the Cushioning Beads™ were milled to a particle size between about 10 mesh and about 50 mesh and to a most preferred size of 30-40 mesh, the Cushioning Beads™ did not loose their ability to protect coated particles during compression, as would be expected because of the fine milling. Moreover, it was also discovered that tablets compressed from the milled Cushioning Beads™ immediately disperse in the mouth. A final advantage of the current invention is the improved hardness and friability. The invention produces a tablet of 2Kp or 20N hardness. A vast improvement because it allows for use of conventional manufacturing and packaging equipment.