Nicholas Stephen Farrell

US Patent:

6350740, Feb 26, 2002

Filed:

Sep 5, 2000

Appl. No.:

09/654882

Inventors:

Nicholas Farrell - Richmond VA

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 3324

US Classification:

514185, 514184, 514186, 514187, 514188, 514492, 544225, 546 2, 546 10, 556137, 548101, 548108

Abstract:

The invention provides a method for enhancing the water solubility of cytotoxic trans-platinum complexes. The present invention also provides a method for killing tumor cells, and a method for the treatment of tumors by the administration of a cytotoxic platinum coordination complex of the general formula SP4-2-[PtX(L)(Lâ)(B)].

US Patent:

7579373, Aug 25, 2009

Filed:

Aug 22, 2002

Appl. No.:

10/225436

Inventors:

Nicholas Farrell - Richmond VA, US
Alexander Hegmans - Kingston, CA
John D. Roberts - Richmond VA, US

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 31/27
A61K 31/28
C07F 15/00

US Classification:

514478, 514483, 514492, 556137

Abstract:

Pro-drug forms of linear polyamine-bridged platinum compounds and methods for their production and use are provided. The polyamine-bridge portion of the compounds is based on spermine or spermidine, and the central amines of the polyamine-bridge are chemically bonded to labile blocking groups. The presence of the blocking groups serves to minimize the toxicity of the Pt compounds upon administration. Selective removal of the blocking groups and release of the active, unblocked species occurs upon exposure to suitable environmental conditions.

US Patent:

8324197, Dec 4, 2012

Filed:

Aug 11, 2006

Appl. No.:

11/502621

Inventors:

Nicholas P. Farrell - Richmond VA, US

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 31/555
C07F 15/00

US Classification:

514184, 544225, 546 2, 548101

Abstract:

Trans-platinum compounds comprising carboxylato groups are disclosed, with anti-cancer usefulness. The carboxylato groups participate in solubilizing trans-platinum compounds to which they are attached.

US Patent:

60606169, May 9, 2000

Filed:

Oct 14, 1998

Appl. No.:

9/051468

Inventors:

Nicholas P. Farrell - Richmond VA
Erneston Menta - Cernusco Sul Naviglio, IT
Roberto Di Domenico - Milan, IT
Silvano Spinelli - Monza, IT

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ
Virginia Commonwealth University - Richmond VA

International Classification:

C07F 1500

US Classification:

556137

Abstract:

Bis-platinum(II) complexes with polymethylene derivatives, the method of making the complexes, and the use of the complexes for the treatment of tumors in mammals, are disclosed. The method of making the polymethylene derivatives, is also disclosed.

US Patent:

63133334, Nov 6, 2001

Filed:

Apr 27, 2000

Appl. No.:

9/446867

Inventors:

Giovanni Da Re - Milan, IT
Roberto Di Domenico - Milan, IT
Silvano Spinelli - Monza, IT
Nicholas Farrell - Richmond VA

Assignee:

Setanta Therapeutics, Inc. - Richmond VA

International Classification:

C07F 1500
A61K 31282

US Classification:

556137

Abstract:

The present invention relates to tetra- and penta-nuclear platinum complexes with antitumor activity, to a method for preparing them and to pharmaceutical compositions containing them.

US Patent:

61139343, Sep 5, 2000

Filed:

Jun 11, 1998

Appl. No.:

9/095565

Inventors:

Nicholas Farrell - Richmond VA
Ulrich Bierbach - Richmond VA

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A01N 2502
A61K 3324

US Classification:

424405

Abstract:

The present invention relates to treatment of viral infections, such as HIV, with a new class of anti-viral platinum coordination compounds having the general structural formula [PtXA. sub. m B. sub. 3-m ] where X is an anionic ligand, A is an acyclic, nitrogen containing monodentate ligand such as amines, ammines, and quinolines, and B is nucleobase.

US Patent:

60111666, Jan 4, 2000

Filed:

Jul 25, 1997

Appl. No.:

8/836667

Inventors:

Mariella Valsecchi - Monza, IT
Paolo Pavesi - Monza, IT
Carlo Bugatti - Monza, IT
Ernesto Menta - Monza, IT
Fernando Giuliani - Monza, IT
Carla Manzotti - Monza, IT
Silvano Spinelli - Monza, IT
Nicholas Farrell - Richmond VA

Assignee:

F. Hoffmann-La Roche AG - Basel

International Classification:

C07F 1500

US Classification:

556137

Abstract:

The present invention relates to trinuclear cationic platinum complexes with alkylene diamine groups connecting the three platinum moieties. The invention also relates to the antitumor activity of these complexes as well as the processes for the preparation thereof and pharmaceutical compositions containing them.

US Patent:

57444978, Apr 28, 1998

Filed:

Sep 27, 1996

Appl. No.:

8/714083

Inventors:

Mariella Valsecchi - Monza, IT
Marco Conti - Monza, IT
Luisa Del Greco - Monza, IT
Carlo Bugatti - Monza, IT
Ernesto Menta - Monza, IT
Ferdinando Giuliani - Monza, IT
Carla Manzotti - Monza, IT
Silvano Spinelli - Monza, IT
Nicholas Farrell - Richmond VA

Assignee:

Boehringer Mannheim Italia, S.p.A. - Milan

International Classification:

C07F 1500
A61K 3128

US Classification:

514492

Abstract:

Compounds of general formula (I) wherein: n is an integer from 2 to 7 included; Z. sup. -m is an anion selected from chloride, bromide, iodide, nitrate, sulfate; m is the integer 1 or 2. Said compounds have antitumour activity.