Nicholas C Farrell

US Patent:

50266942, Jun 25, 1991

Filed:

Jun 30, 1989

Appl. No.:

7/374356

Inventors:

Kirsten A. Skov - Vancouver, CA
Nicholas P. Farrell - Winooski VT
David J. Chaplin - Richmond, CA

Assignee:

The British Columbia Cancer Foundation - Vancouver

International Classification:

A61K 31555

US Classification:

514184

Abstract:

Methods to inhibit tumor growth and to radiosensitize hypoxic cells and pharmaceutical compositions therefor are disclosed. These methods and compositions use compounds of the formula PtX. sub. n (NR. sub. 2 H) (L) (1) wherein n is 1 or 2, and wherein when n is 2, X is a monovalent biologically acceptable anion, and when n is 1, X is a divalent biologically acceptable anion; each R is independently H or alkyl, or both Rs together are a piperidino or morpholino residue; and L is a radiosensitizing ligand selected from a mononitro-substituted imidazole, a mononitro-substituted pyrazole, a mononitro-substituted thiazole and a mononitro-substituted isothiazole.

US Patent:

48717290, Oct 3, 1989

Filed:

Jan 9, 1989

Appl. No.:

7/294790

Inventors:

Nicholas Farrell - Winooski VT
Miles P. Hacker - Williston VT
John J. McCormack - Burlington VT
Sergio G. DeAlmeida - Winooski VT

Assignee:

University of Vermont and State Agricultural College - Burlington VT

International Classification:

A61K 31555

US Classification:

514188

Abstract:

A bis-platinum complex having the structure: ##STR1## wherein X and Y are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate or dicarboxylate. B and C are the same or different and are primary or secondary amines, or pyridine type nitrogens. A is a diamine or polyamine wherein the primary amine N atoms are coordinated to the Pt atom such that platinum is present as Pt. sup. 2+. The complexes are useful in the inhibition of tumors.

US Patent:

47973935, Jan 10, 1989

Filed:

Jul 25, 1986

Appl. No.:

6/889397

Inventors:

Nicholas Farrell - Winooski VT
Miles P. Hacker - Williston VT
John J. McCormack - Burlington VT
Sergio G. DeAlmeida - Winooski VT

Assignee:

University of Vermont and State Agricultural College - Burlington VT

International Classification:

C07F 1500

US Classification:

514188

Abstract:

A bis-platinum complex having the structure: ##STR1## wherein X and Y are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate or dicarboxylate. B and C are the same or different and are primary or secondary amines, or pyridine type nitrogens. A is a diamine or polyamine wherein the primary amine N atoms are coordinated to the Pt atom such that platinum is present as Pt. sup. 2+. The complexes are useful in the inhibition of tumors.

US Patent:

50287265, Jul 2, 1991

Filed:

Feb 7, 1990

Appl. No.:

7/476235

Inventors:

Nicholas P. Farrell - Shelburne VT

Assignee:

The University of Vermont and State Agricultural College - Burlington VT

International Classification:

C07F 1500
A61K 3300

US Classification:

556137

Abstract:

Platinum amine sulfoxide complexes of the formula [PtCl(diam)(R. sub. 2 SO)]. sup. + X. sup. - wherein diam represents a bidentate amine, R is C. sub. 3 -C. sub. 7 alkyl or cycloalkyl and X. sup. - is an anion, exhibit favorable anti-tumor activity in vivo against tumors susceptible to therapy with platinum.

US Patent:

57705917, Jun 23, 1998

Filed:

Nov 10, 1994

Appl. No.:

8/339291

Inventors:

Nicholas Farrell - Winooski VT

Assignee:

The University of Vermont and State Agricultural College - Burlington VT

International Classification:

C07F 1500
A61K 31555

US Classification:

514187

Abstract:

A bis(platinum) complex having the structure: ##STR1## wherein X, Y, Z, X', Y', and Z' are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate, dicarboxylate, substituted dicarboxylate primary or secondary amine, sulfoxide, phosphine, pyridine-type nitrogen and the like; preferably, there is at least one Pt-anion bond on each Pt molecule; and A is a diamine or polyamine. Complexes of trans geometry �PtX. sub. 2 (L)(L')! where at least L is a planar ligand such as pyridine but preferably quinoline and L' may be amine, sulfoxide or substituted sulfoxide and X is a chloride, nitrate or carboxylate. A process for obtaining bis(platinum) complexes where the two platinum coordination spheres may contain different ligands in each sphere and where the geometry of each platinum coordination sphere may be the same or different.

US Patent:

49219634, May 1, 1990

Filed:

Apr 13, 1987

Appl. No.:

7/037498

Inventors:

Kirsten A. Skov - Vancouver, CA
Nicholas P. Farrell - Winooski VT
David J. Chaplin - Richmond, CA

Assignee:

British Columbia Cancer Foundation - Vancouver

International Classification:

C07F 1702

US Classification:

548101

Abstract:

Complexes of platinum II containing a single radiosensitizer ligand and an amino or ammine substituent shows superior binding to DNA and are useful in chemotherapy and sensitization of hypoxic tumors to radiation. The chemotherapeutic value of these compounds is enhanced by administration of vasoactive agents.

US Patent:

51070073, Apr 21, 1992

Filed:

Sep 1, 1989

Appl. No.:

7/401919

Inventors:

Nicholas Farrell - Winooski VT

Assignee:

The University of Vermont and State Agricultural College - Burlington VT

International Classification:

C07F 1500

US Classification:

556137

Abstract:

A bis(platinum) complex having the structure: ##STR1## wherein X, Y, Z, X', Y', and Z' are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate, dicarboxylate, substituted dicarboxylate primary or secondary amine, sulfoxide, phosphine, pyridine-type nitrogen and the like; preferably, there is at least one Pt-anion bond on each Pt molecule; and A is a diamine or polyamine. Complexes of trans geometry [PtX. sub. 2 (L)(L')] where at least L is a planar ligand such as pyridine but preferably quinoline and L' may be amine, sulfoxide or substituted sulfoxide and X is a chloride, nitrate or carboxylate. A process for obtaining bis(platinum) complexes where the two platinum coordination spheres may contain different ligands in each sphere and where the geometry of each platinum coordination sphere may be the same or different.

US Patent:

53808975, Jan 10, 1995

Filed:

May 25, 1993

Appl. No.:

8/066581

Inventors:

James D. Hoeschele - Canton MI
Yun Qu - Burlington VT
Nicholas Farrell - Shelburne VT

International Classification:

C07F 1500
A61K 3128
A61K 3166

US Classification:

556137

Abstract:

Novel tri(platinum) complexes containing three platinum coordination spheres coupled via diamine or triamine bridging agents are taught as well as methods for their preparation. These complexes are to be used as pharmaceutical agents, e. g. , for the treatment of cancer and parasitic diseases.