Nicholas P Farrell

US Patent:

6350740, Feb 26, 2002

Filed:

Sep 5, 2000

Appl. No.:

09/654882

Inventors:

Nicholas Farrell - Richmond VA

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 3324

US Classification:

514185, 514184, 514186, 514187, 514188, 514492, 544225, 546 2, 546 10, 556137, 548101, 548108

Abstract:

The invention provides a method for enhancing the water solubility of cytotoxic trans-platinum complexes. The present invention also provides a method for killing tumor cells, and a method for the treatment of tumors by the administration of a cytotoxic platinum coordination complex of the general formula SP4-2-[PtX(L)(Lâ)(B)].

US Patent:

7579373, Aug 25, 2009

Filed:

Aug 22, 2002

Appl. No.:

10/225436

Inventors:

Nicholas Farrell - Richmond VA, US
Alexander Hegmans - Kingston, CA
John D. Roberts - Richmond VA, US

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 31/27
A61K 31/28
C07F 15/00

US Classification:

514478, 514483, 514492, 556137

Abstract:

Pro-drug forms of linear polyamine-bridged platinum compounds and methods for their production and use are provided. The polyamine-bridge portion of the compounds is based on spermine or spermidine, and the central amines of the polyamine-bridge are chemically bonded to labile blocking groups. The presence of the blocking groups serves to minimize the toxicity of the Pt compounds upon administration. Selective removal of the blocking groups and release of the active, unblocked species occurs upon exposure to suitable environmental conditions.

US Patent:

8324197, Dec 4, 2012

Filed:

Aug 11, 2006

Appl. No.:

11/502621

Inventors:

Nicholas P. Farrell - Richmond VA, US

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 31/555
C07F 15/00

US Classification:

514184, 544225, 546 2, 548101

Abstract:

Trans-platinum compounds comprising carboxylato groups are disclosed, with anti-cancer usefulness. The carboxylato groups participate in solubilizing trans-platinum compounds to which they are attached.

US Patent:

50266942, Jun 25, 1991

Filed:

Jun 30, 1989

Appl. No.:

7/374356

Inventors:

Kirsten A. Skov - Vancouver, CA
Nicholas P. Farrell - Winooski VT
David J. Chaplin - Richmond, CA

Assignee:

The British Columbia Cancer Foundation - Vancouver

International Classification:

A61K 31555

US Classification:

514184

Abstract:

Methods to inhibit tumor growth and to radiosensitize hypoxic cells and pharmaceutical compositions therefor are disclosed. These methods and compositions use compounds of the formula PtX. sub. n (NR. sub. 2 H) (L) (1) wherein n is 1 or 2, and wherein when n is 2, X is a monovalent biologically acceptable anion, and when n is 1, X is a divalent biologically acceptable anion; each R is independently H or alkyl, or both Rs together are a piperidino or morpholino residue; and L is a radiosensitizing ligand selected from a mononitro-substituted imidazole, a mononitro-substituted pyrazole, a mononitro-substituted thiazole and a mononitro-substituted isothiazole.

US Patent:

60606169, May 9, 2000

Filed:

Oct 14, 1998

Appl. No.:

9/051468

Inventors:

Nicholas P. Farrell - Richmond VA
Erneston Menta - Cernusco Sul Naviglio, IT
Roberto Di Domenico - Milan, IT
Silvano Spinelli - Monza, IT

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ
Virginia Commonwealth University - Richmond VA

International Classification:

C07F 1500

US Classification:

556137

Abstract:

Bis-platinum(II) complexes with polymethylene derivatives, the method of making the complexes, and the use of the complexes for the treatment of tumors in mammals, are disclosed. The method of making the polymethylene derivatives, is also disclosed.

US Patent:

48717290, Oct 3, 1989

Filed:

Jan 9, 1989

Appl. No.:

7/294790

Inventors:

Nicholas Farrell - Winooski VT
Miles P. Hacker - Williston VT
John J. McCormack - Burlington VT
Sergio G. DeAlmeida - Winooski VT

Assignee:

University of Vermont and State Agricultural College - Burlington VT

International Classification:

A61K 31555

US Classification:

514188

Abstract:

A bis-platinum complex having the structure: ##STR1## wherein X and Y are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate or dicarboxylate. B and C are the same or different and are primary or secondary amines, or pyridine type nitrogens. A is a diamine or polyamine wherein the primary amine N atoms are coordinated to the Pt atom such that platinum is present as Pt. sup. 2+. The complexes are useful in the inhibition of tumors.

US Patent:

47973935, Jan 10, 1989

Filed:

Jul 25, 1986

Appl. No.:

6/889397

Inventors:

Nicholas Farrell - Winooski VT
Miles P. Hacker - Williston VT
John J. McCormack - Burlington VT
Sergio G. DeAlmeida - Winooski VT

Assignee:

University of Vermont and State Agricultural College - Burlington VT

International Classification:

C07F 1500

US Classification:

514188

Abstract:

A bis-platinum complex having the structure: ##STR1## wherein X and Y are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate or dicarboxylate. B and C are the same or different and are primary or secondary amines, or pyridine type nitrogens. A is a diamine or polyamine wherein the primary amine N atoms are coordinated to the Pt atom such that platinum is present as Pt. sup. 2+. The complexes are useful in the inhibition of tumors.

US Patent:

50287265, Jul 2, 1991

Filed:

Feb 7, 1990

Appl. No.:

7/476235

Inventors:

Nicholas P. Farrell - Shelburne VT

Assignee:

The University of Vermont and State Agricultural College - Burlington VT

International Classification:

C07F 1500
A61K 3300

US Classification:

556137

Abstract:

Platinum amine sulfoxide complexes of the formula [PtCl(diam)(R. sub. 2 SO)]. sup. + X. sup. - wherein diam represents a bidentate amine, R is C. sub. 3 -C. sub. 7 alkyl or cycloalkyl and X. sup. - is an anion, exhibit favorable anti-tumor activity in vivo against tumors susceptible to therapy with platinum.