Nicholas J Simpson

US Patent:

20140105974, Apr 17, 2014

Filed:

Mar 14, 2012

Appl. No.:

14/000471

Inventors:

Collin J. Weber - Atlanta GA, US
Susan A. Safley - Decatur GA, US
Kereen S. Gordon - Alpharetta GA, US
Nicholas E. Simpson - Alachua FL, US

Assignee:

EMORY UNIVERSITY - Atlanta GA

International Classification:

A61K 9/48
A61K 35/39

US Classification:

424463, 424 937, 4241781

Abstract:

This disclosure relates to compositions and methods for encapsulating biomaterials such as cells to prevent immune responses. In certain embodiments the disclosure relates to capsules comprising a cell or cells gelled in alginate coated with a layer that prevents migration of immune molecules to the cell surface and an outer capsule layer comprising non-immunogenic material optionally containing immunosuppressive agents. In certain embodiments, the cells are capable of generating insulin that emanates from the capsule.