Nicholas Edward Simpson

US Patent:

20100172994, Jul 8, 2010

Filed:

Nov 23, 2007

Appl. No.:

12/445299

Inventors:

Wolfgang M. Sigmund - Gainesville FL, US
Yi-Yang Tsai - Brandon FL, US
Ioannis Constantinidis - Gainesville FL, US
Jenny Dorley - Gainesville FL, US
Carol Ann Sweeney - Micanopy FL, US
Nicholas Edward Simpson - Alachua FL, US
Mark A. Atkinson - Gainesville FL, US

Assignee:

UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. - GAINESVILLE FL

International Classification:

A61K 9/14
A61K 35/12
A61K 33/24

US Classification:

424489, 424 937, 424617, 435375, 977773, 977904

Abstract:

The present invention concerns metal oxide semiconductor nanoparticles with free radical scavenging activity, compositions comprising such nanoparticles, methods for their use, and methods for their production. In one aspect, the invention concerns a method for enhancing the survival or viability of transplanted cells, comprising administering an effective amount of metal oxide semiconductor nanoparticles to a target anatomical site of a subject before, during, or after administration of transplant cells to the subject. Preferably, the metal oxide nanoparticle is a cerium oxide (ceria) nanoparticle.

US Patent:

20130023823, Jan 24, 2013

Filed:

Mar 10, 2011

Appl. No.:

13/583648

Inventors:

Nicholas Edward Simpson - Alachua FL, US
Mark John Beveridge - Gainesville FL, US
Nelly Aline Volland - Salt Lake City UT, US

Assignee:

UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC. - GAINESVILLE FL

International Classification:

A61M 31/00
B29C 67/24

US Classification:

604 9301, 264241

Abstract:

The subject invention pertains to an implantable therapeutic device for treating diabetes and methods of making. Upon implantation, the present device secretes insulin in response to blood glucose levels, exquisitely regulates blood glucose levels, reduces hyperglycemia, and includes β-cell regeneration in the host. It is useful for treating or ameliorating diabetes or diabetic conditions of a subject, including but not limited to, type 1 diabetes mellitus, hyperglycemia, impaired glucose tolerance, insulin deficiency, elevated glucose levels, and insulin resistance.

US Patent:

20140105974, Apr 17, 2014

Filed:

Mar 14, 2012

Appl. No.:

14/000471

Inventors:

Collin J. Weber - Atlanta GA, US
Susan A. Safley - Decatur GA, US
Kereen S. Gordon - Alpharetta GA, US
Nicholas E. Simpson - Alachua FL, US

Assignee:

EMORY UNIVERSITY - Atlanta GA

International Classification:

A61K 9/48
A61K 35/39

US Classification:

424463, 424 937, 4241781

Abstract:

This disclosure relates to compositions and methods for encapsulating biomaterials such as cells to prevent immune responses. In certain embodiments the disclosure relates to capsules comprising a cell or cells gelled in alginate coated with a layer that prevents migration of immune molecules to the cell surface and an outer capsule layer comprising non-immunogenic material optionally containing immunosuppressive agents. In certain embodiments, the cells are capable of generating insulin that emanates from the capsule.