Nicholas X Vernon

US Patent:

6943248, Sep 13, 2005

Filed:

Apr 30, 2003

Appl. No.:

10/426387

Inventors:

Steven J. Catani - Athens GA, US
Carolyn M. Merkel - North Haledon NJ, US
Nicholas M. Vernon - Daphne AL, US

Assignee:

Tate & Lyle Public Limited Company

International Classification:

C07H001/00
C07H003/04

US Classification:

536124, 53612313, 536127, 536122, 536 41

Abstract:

A crystalline form of sucralose, and a method of making it. The method involves continuously crystallizing sucralose from an aqueous solution by a process providing continuous removal and recirculation of the vessel contents, and providing a long residence time for sucralose in the system. The crystals thus formed are of a relatively low length/diameter ratio, have an unsymmetrical shape, and exhibit good stability. The larger crystals in particular are tapered as compared to the rod-like larger crystals in prior art product.

US Patent:

6998480, Feb 14, 2006

Filed:

Mar 8, 2002

Appl. No.:

10/092730

Inventors:

Steven J. Catani - Athens GA, US
James E. Wiley - Daphne AL, US
Nicholas M. Vernon - Daphne AL, US
Carolyn M. Merkel - North Haledon NJ, US
Edward Micinski - Martinez GA, US

Assignee:

Tate & Lyle Public Limited Company - London

International Classification:

C07H 13/02

US Classification:

536124, 514 53

Abstract:

This invention relates to processes for purifying sucralose by the use of an initial non-crystallization purification procedure followed by three or more sequential crystallization steps and recycle of the mother liquor remaining from each crystallization step to the feed of another crystallization or purification step. This invention also relates to sucralose compositions as well as compositions comprising the sucralose compositions of the present invention. These compositions may be highly pure and have a superior taste profile.

US Patent:

7049435, May 23, 2006

Filed:

Mar 8, 2002

Appl. No.:

10/092715

Inventors:

Steven J. Catani - Athens GA, US
Nicholas M. Vernon - Daphne AL, US
David Saul Neiditch - Athens GA, US
Edward Micinski - Martinez GA, US

Assignee:

Tate & Lyle Public Limited Company - London

International Classification:

C07H 1/06

US Classification:

536124, 536 111, 536127

Abstract:

The present invention relates to novel extractive methods for purifying sucralose. The present invention also relates to compositions comprising the sucralose preparations made by the methods of the present invention.

US Patent:

20040030124, Feb 12, 2004

Filed:

Aug 6, 2002

Appl. No.:

10/213387

Inventors:

Steven Catani - Athens GA, US
Mark Huber - Mobile AL, US
Nicholas Vernon - Daphne AL, US

International Classification:

C07H003/00

US Classification:

536/123130

Abstract:

This invention relates to a crystallization process for sucralose in which a mother liquor is obtained by separating crystalline sucralose from the remaining liquid. A portion of this mother liquor is returned to the same crystallization stage; the amount returned is adjusted so as to maintain the overall related substances level in the process below levels at which yield declines significantly.

US Patent:

20050203290, Sep 15, 2005

Filed:

May 13, 2005

Appl. No.:

11/128501

Inventors:

Steven Catani - Athens GA, US
Carolyn Merkel - North Haledon NJ, US
Nicholas Vernon - Daphne AL, US

International Classification:

C07H003/00

US Classification:

536123130

Abstract:

A crystalline form of sucralose, and a method of making it. The method involves continuously crystallizing sucralose from an aqueous solution by a process providing continuous removal and recirculation of the vessel contents, and providing a long residence time for sucralose in the system. The crystals thus formed are of a relatively low length/diameter ratio, have an unsymmetrical shape, and exhibit good stability. The larger crystals in particular are tapered as compared to the rod-like larger crystals in prior art product.

US Patent:

49804634, Dec 25, 1990

Filed:

Jul 18, 1989

Appl. No.:

7/382147

Inventors:

Robert E. Walkup - Watkinsville GA
Juan L. Navia - Athens GA
Nicholas M. Vernon - Athens GA

Assignee:

Noramco, Inc. - Atlanta GA

International Classification:

C07H 100
C07H 1300
C07G 300

US Classification:

536124

Abstract:

A process for the chlorination of sucrose-6-esters to produce 6',4,1'-trichlorosucrose-6-esters which comprises the steps of: (a) adding at least seven molar equivalents of an acid chloride to a reaction mixture containing a sucrose-6-ester and a tertiary amide to form initially a chloroformiminium chloride salt which subsequently forms a complex with the hydroxyl groups of the sucrose-6-ester; (b) subjecting the reaction mixture product of step (a) to an elevated temperature not higher than about 85. degree. C. for a period of time sufficient to produce a mixture of chlorinated sucrose-6-ester products consisting essentially of 6'-chlorosucrose-6-ester, 4,6'-dichlorosucrose-6-ester, and 1',6'-dichlorosucrose-6-ester; and (c) subjecting the reaction mixture product of step (b) to an elevated temperature not higher than about 125. degree. C. for a period of time sufficient to produce a chlorinated product consisting essentially of 1',4,6'-trichlorosucrose-6-ester.

US Patent:

50345516, Jul 23, 1991

Filed:

Apr 23, 1990

Appl. No.:

7/512690

Inventors:

Nicholas M. Vernon - Athens GA
Robert E. Walkup - Watkinsville GA

Assignee:

Noramco, Inc. - Athens GA

International Classification:

C07H 722

US Classification:

556 89

Abstract:

A process which comprises extracting 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl) distannoxane from a mixture containing 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane, a sucrose-6-ester, and polar aprotic solvent, which process comprises the steps of: (a) contacting said mixture, in the presence of a small amount of water, with an organic solvent that is substantially immiscible with water to form thereby an extraction mixture, wherein the amount of water employed is sufficient to cause efficient partitioning of said 1,3-diacyloxy-1,1,3,3-tetra(hydrocarbyl)distannoxane from a first phase comprising said polar aprotic solvent into second phase comprising said organic solvent; (b) agitating the extraction mixture for a period of time and at a temperature sufficient to form thereby a two-phase mixture wherein the preponderance of the 1,3-diacyloxy-1,1,3,3-tetra(hydrocabyl)distannoxane in the extraction mixture is contained in said second phase and essentially all of the sucrose-6-ester in the extraction mixture is contained in said first phase; and (c) separating said first phase from said second phase.

US Patent:

54987091, Mar 12, 1996

Filed:

May 24, 1995

Appl. No.:

8/448710

Inventors:

Juan L. Navia - Athens GA
Robert E. Walkup - Watkinsville GA
Nicholas M. Vernon - Watkinsville GA
David S. Neiditch - Athens GA

Assignee:

McNeil-PPC, Inc. - Milltown NJ

International Classification:

C07G 1700
C07H 100
C07H 300

US Classification:

536124

Abstract:

There is disclosed a process for producing sucralose from sucralose-6-ester whereby the sucralose-6-ester is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination reaction mixture, to produce an aqueous solution of sucralose plus salts and impurities, from which sucralose is recovered by extraction and is then preferably purified by crystallization.