Nicholas M Vernon

US Patent:

6890581, May 10, 2005

Filed:

Apr 5, 2002

Appl. No.:

10/116758

Inventors:

Nicholas M. Vernon - Daphne AL, US
Edward Micinski - Martinez GA, US
Steven J. Catani - Athens GA, US
Juan L. Navia - Doylestown PA, US

Assignee:

Tate & Lyle Public Limited Company - London

International Classification:

A23G003/00
C07H001/06

US Classification:

426658, 426548, 536124, 536127

Abstract:

The present invention relates to novel methods for stabilizing aqueous deacylation, via use of buffers in the production of sucralose. The present invention provides a process for producing sucralose from an acyl-sucralose compound whereby the acyl-sucralose compound is deacylated in the presence of a buffering agent, which stabilizes the pH of the feed mixture and decreases the accumulation of undesired anhydro compounds. Further, the present invention provides a process whereby the acyl-sucralose compound is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination feed mixture. An aqueous solution of sucralose including salts and other compounds is produced, from which sucralose is recovered by extraction and purified by crystallization.

US Patent:

6943248, Sep 13, 2005

Filed:

Apr 30, 2003

Appl. No.:

10/426387

Inventors:

Steven J. Catani - Athens GA, US
Carolyn M. Merkel - North Haledon NJ, US
Nicholas M. Vernon - Daphne AL, US

Assignee:

Tate & Lyle Public Limited Company

International Classification:

C07H001/00
C07H003/04

US Classification:

536124, 53612313, 536127, 536122, 536 41

Abstract:

A crystalline form of sucralose, and a method of making it. The method involves continuously crystallizing sucralose from an aqueous solution by a process providing continuous removal and recirculation of the vessel contents, and providing a long residence time for sucralose in the system. The crystals thus formed are of a relatively low length/diameter ratio, have an unsymmetrical shape, and exhibit good stability. The larger crystals in particular are tapered as compared to the rod-like larger crystals in prior art product.

US Patent:

6998480, Feb 14, 2006

Filed:

Mar 8, 2002

Appl. No.:

10/092730

Inventors:

Steven J. Catani - Athens GA, US
James E. Wiley - Daphne AL, US
Nicholas M. Vernon - Daphne AL, US
Carolyn M. Merkel - North Haledon NJ, US
Edward Micinski - Martinez GA, US

Assignee:

Tate & Lyle Public Limited Company - London

International Classification:

C07H 13/02

US Classification:

536124, 514 53

Abstract:

This invention relates to processes for purifying sucralose by the use of an initial non-crystallization purification procedure followed by three or more sequential crystallization steps and recycle of the mother liquor remaining from each crystallization step to the feed of another crystallization or purification step. This invention also relates to sucralose compositions as well as compositions comprising the sucralose compositions of the present invention. These compositions may be highly pure and have a superior taste profile.

US Patent:

7049435, May 23, 2006

Filed:

Mar 8, 2002

Appl. No.:

10/092715

Inventors:

Steven J. Catani - Athens GA, US
Nicholas M. Vernon - Daphne AL, US
David Saul Neiditch - Athens GA, US
Edward Micinski - Martinez GA, US

Assignee:

Tate & Lyle Public Limited Company - London

International Classification:

C07H 1/06

US Classification:

536124, 536 111, 536127

Abstract:

The present invention relates to novel extractive methods for purifying sucralose. The present invention also relates to compositions comprising the sucralose preparations made by the methods of the present invention.

US Patent:

20040030124, Feb 12, 2004

Filed:

Aug 6, 2002

Appl. No.:

10/213387

Inventors:

Steven Catani - Athens GA, US
Mark Huber - Mobile AL, US
Nicholas Vernon - Daphne AL, US

International Classification:

C07H003/00

US Classification:

536/123130

Abstract:

This invention relates to a crystallization process for sucralose in which a mother liquor is obtained by separating crystalline sucralose from the remaining liquid. A portion of this mother liquor is returned to the same crystallization stage; the amount returned is adjusted so as to maintain the overall related substances level in the process below levels at which yield declines significantly.

US Patent:

20050170069, Aug 4, 2005

Filed:

Mar 25, 2005

Appl. No.:

11/089709

Inventors:

Nicholas Vernon - Daphne AL, US
Edward Micinski - Martinez GA, US
Steven Catani - Athens GA, US
Juan Navia - Doylestown PA, US

International Classification:

A23G003/30

US Classification:

426658000

Abstract:

The present invention relates to novel methods for stabilizing aqueous deacylation, via use of buffers in the production of sucralose. The present invention provides a process for producing sucralose from an acyl-sucralose compound whereby the acyl-sucralose compound is deacylated in the presence of a buffering agent, which stabilizes the pH of the feed mixture and decreases the accumulation of undesired anhydro compounds. Further, the present invention provides a process whereby the acyl-sucralose compound is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination feed mixture. An aqueous solution of sucralose including salts and other compounds is produced, from which sucralose is recovered by extraction and purified by crystallization.

US Patent:

20050203290, Sep 15, 2005

Filed:

May 13, 2005

Appl. No.:

11/128501

Inventors:

Steven Catani - Athens GA, US
Carolyn Merkel - North Haledon NJ, US
Nicholas Vernon - Daphne AL, US

International Classification:

C07H003/00

US Classification:

536123130

Abstract:

A crystalline form of sucralose, and a method of making it. The method involves continuously crystallizing sucralose from an aqueous solution by a process providing continuous removal and recirculation of the vessel contents, and providing a long residence time for sucralose in the system. The crystals thus formed are of a relatively low length/diameter ratio, have an unsymmetrical shape, and exhibit good stability. The larger crystals in particular are tapered as compared to the rod-like larger crystals in prior art product.

US Patent:

49804634, Dec 25, 1990

Filed:

Jul 18, 1989

Appl. No.:

7/382147

Inventors:

Robert E. Walkup - Watkinsville GA
Juan L. Navia - Athens GA
Nicholas M. Vernon - Athens GA

Assignee:

Noramco, Inc. - Atlanta GA

International Classification:

C07H 100
C07H 1300
C07G 300

US Classification:

536124

Abstract:

A process for the chlorination of sucrose-6-esters to produce 6',4,1'-trichlorosucrose-6-esters which comprises the steps of: (a) adding at least seven molar equivalents of an acid chloride to a reaction mixture containing a sucrose-6-ester and a tertiary amide to form initially a chloroformiminium chloride salt which subsequently forms a complex with the hydroxyl groups of the sucrose-6-ester; (b) subjecting the reaction mixture product of step (a) to an elevated temperature not higher than about 85. degree. C. for a period of time sufficient to produce a mixture of chlorinated sucrose-6-ester products consisting essentially of 6'-chlorosucrose-6-ester, 4,6'-dichlorosucrose-6-ester, and 1',6'-dichlorosucrose-6-ester; and (c) subjecting the reaction mixture product of step (b) to an elevated temperature not higher than about 125. degree. C. for a period of time sufficient to produce a chlorinated product consisting essentially of 1',4,6'-trichlorosucrose-6-ester.