Ning Fam Li

US Patent:

20030097670, May 22, 2003

Filed:

Nov 21, 2001

Appl. No.:

09/990185

Inventors:

Krzysztof Palczewski - Bellevue WA, US
Ning Li - San Diego CA, US
Juan Ballesteros - Encinitas CA, US

International Classification:

A01K067/027
C12P021/02
C12N005/06
C07K014/705

US Classification:

800/018000, 435/354000, 435/320100, 530/350000

Abstract:

The invention provides a gene targeting construct containing a transgene encoding a polypeptide that contains a rod outer segment (ROS) targeting signal. The transgene is flanked by 5′ and 3′ DNA sequences that are homologous to the rhodopsin gene. Homologous recombination between the construct and a rhodopsin gene results in operable association between the transgene and a rod-specific regulatory sequence. The invention also provides cells and animals whose genome contain a functional disruption of one or both endogenous rhodopsin gene alleles, and a transgene encoding a polypeptide that contains a ROS targeting signal operably associated with a rod-specific regulatory sequence. The invention constructs, cell and animals can be used to isolate transgenic polypeptides from the ROS membrane.

US Patent:

20040244070, Dec 2, 2004

Filed:

Apr 22, 2004

Appl. No.:

10/830908

Inventors:

Krzysztof Palczewski - Bellevue WA, US
Ning Li - San Diego CA, US
Juan Ballesteros - Encinitas CA, US

Assignee:

Novasite Pharmaceuticals, Inc.

International Classification:

A01K067/027
C12Q001/68
C07H021/04
C12N005/06
C07K014/705

US Classification:

800/018000, 435/006000, 435/069100, 435/320100, 435/354000, 536/023500, 530/350000

Abstract:

The invention provides a gene targeting construct containing a transgene encoding a polypeptide that contains a rod outer segment (ROS) targeting signal. The transgene is flanked by 5′ and 3′ DNA sequences that are homologous to the rhodopsin gene. Homologous recombination between the construct and a rhodopsin gene results in operable association between the transgene and a rod-specific regulatory sequence. The invention also provides cells and animals whose genome contain a functional disruption of one or both endogenous rhodopsin gene alleles, and a transgene encoding a polypeptide that contains a ROS targeting signal operably associated with a rod-specific regulatory sequence. The invention constructs, cell and animals can be used to isolate transgenic polypeptides from the ROS membrane.

US Patent:

20050091702, Apr 28, 2005

Filed:

Apr 23, 2004

Appl. No.:

10/831773

Inventors:

Krzysztof Palczewski - Bellevue WA, US
Ning Li - San Diego CA, US
Juan Ballesteros - Encinitas CA, US

International Classification:

A01K067/00
C12N015/85

US Classification:

800008000, 435320100, 435455000, 435325000

Abstract:

The invention provides a transgene construct consisting of a transgene encoding a membrane polypeptide comprising a rod outer segment (ROS) targeting signal, and an operably associated species specific rod-specific regulatory sequence, wherein said polypeptide is not rhodopsin. The membrane polypeptide can be a G protein-coupled receptor (GPCR). Transgenic membrane polypeptides include a receptor selected from 5HT, 5HT, 5HT, 5HT, 5HT, 5HT, 5HT, 5HT, 5HT, 5HT, 5HT, 5HT, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, CB2, FMLP and MC4. The invention also provides a cell whose genome contains a transgene encoding a membrane polypeptide comprising a ROS targeting signal operably associated with a rod-specific regulatory sequence, wherein said polypeptide is not a rhodopsin. A tadpole or adult whose genome contains a transgene encoding a membrane polypeptide comprising a ROS targeting signal operably associated with a rod-specific regulatory sequence, wherein said polypeptide is not a rhodopsin is further provided.

US Patent:

20050124792, Jun 9, 2005

Filed:

Nov 21, 2002

Appl. No.:

10/495994

Inventors:

Krzysztof Palczewski - Bellevue WA, US
Ning Li - San Diego CA, US
Juan Ballesteros - Encinitas CA, US

International Classification:

C07K014/705
C07H021/04
C12N005/06

US Classification:

530350000, 536023500, 435069100, 435320100, 435325000, 435354000

Abstract:

The invention provides a transgene construct, containing a nucleic acid encoding a photoreceptor specific regulatory sequence, a membrane-associated polypeptide, and a photoreceptor outer segment targeting signal. For example, the invention pro-vides a transgene construct, containing a nucleic acid encoding a rhodopsin promoter, a membrane-associated polypeptide, and a rod outer segment (ROS) targeting signal. In addition, the invention provides a gene targeting construct containing a transgene encoding a polypeptide that contains a rod outer segment (ROS) targeting signal. The transgene is flanked by 5′ and 3′ DNA sequences that are homologous to the rhodopsin gene. Homologous recombination between the construct and a rhodopsin gene results in operable association between the transgene and a rod-specific regulatory sequence. The invention also provides cells and animals whose genome contain a functional disruption of one or both endogenous rhodopsin gene alleles, and a transgene encoding a polypeptide that contains a ROS targeting signal operably associated with a rod-specific regulatory sequence. The invention constructs, cell and animals can be used to isolate transgenic polypeptides from the ROS membrane.

US Patent:

20180228425, Aug 16, 2018

Filed:

Feb 15, 2018

Appl. No.:

15/897905

Inventors:

- ELGIN IL, US
Randall Iverson PAUL - Mission Viejo CA, US
Cynthia L. BELL - Woodridge IL, US
Marianela SPUNG - Wauconda IL, US
Caren S. BUSEN - Timewell IL, US
Bradley Joshua BELL - Aurora IL, US
Ning Xiang LI - Sequim WA, US
Anne Catherine URMANSKI - Roswell GA, US

Assignee:

CLINICAL COMPUTER SYSTEMS, INC. - ELGIN IL

International Classification:

A61B 5/00
A61B 5/0488

Abstract:

Uterine activity tools and methods of use thereof. The uterine activity tools of this invention are designed to provide clinicians with information to evaluate uterine activity of a pregnant patient utilizing a fetal monitor with a tocodynamometer external pressure sensor (“TOCO”) and/or an intrauterine pressure catheter (“IUPC”). The tool of this invention displays vital information for assessment and documentation of uterine activity including date, time, mode, contraction frequency, contraction duration, contraction intensity, resting tone, relax time, calculated Montevideo units, and number of contractions in a selected time period.

US Patent:

20170040240, Feb 9, 2017

Filed:

Aug 7, 2015

Appl. No.:

14/821271

Inventors:

- Armonk NY, US
Jeehwan Kim - Los Angeles CA, US
Ning Li - White Plains NY, US
Wencong Liu - Shandong, CN
Devendra K. Sadana - Pleasantville NY, US

International Classification:

H01L 23/31
H01L 21/56
H01L 29/06
H01S 5/22
H01S 5/028

Abstract:

A semiconductor device includes a mesa structure having vertical sidewalls, the mesa structure including an active area comprising a portion of its height. A stressed passivation liner is formed on the vertical sidewalls of the mesa structure and over the portion of the active area. The stressed passivation liner induces strain in the active area to permit tuning of performance parameters of the mesa structure.

US Patent:

20170033305, Feb 2, 2017

Filed:

Jul 31, 2015

Appl. No.:

14/815556

Inventors:

- Armonk NY, US
Jeehwan Kim - Los Angeles CA, US
Ning Li - White Plains NY, US

International Classification:

H01L 51/44
H01L 51/42

Abstract:

A photovoltaic device that includes an organic or quantum dot sensitizer layer for absorbing light spectra and providing excitons. The sensitizer layer may include metal particles embedded therein for increased exciton transfer efficiency. The photovoltaic device may further include a junction comprising an electron donor layer and electron acceptor layer for charge carrier transport.

US Patent:

20170005229, Jan 5, 2017

Filed:

Jun 30, 2015

Appl. No.:

14/788018

Inventors:

- Armonk NY, US
Jeehwan Kim - Los Angeles CA, US
Ning Li - White Plains NY, US
Devendra K. Sadana - Pleasantville NY, US

International Classification:

H01L 33/30
H01L 33/38
H01L 33/14
H01L 33/42
H01L 33/00

Abstract:

A light emitting diode (LED) includes a p-type ohmic contact and a p-type substrate in contact with the p-type ohmic contact. A p-type confinement layer is provided on the p-type substrate. An emission layer is provided on the p-type confinement layer. An n-type confinement layer is provided on the emission layer. A transparent II-VI n-type contact layer is formed on the n-type confinement layer as a replacement for a current spreading layer, a III-V contact layer and an n-type ohmic contact.