Noah F Shroyer

US Patent:

7141420, Nov 28, 2006

Filed:

Jan 10, 2003

Appl. No.:

10/340097

Inventors:

Rando Allikmets - Frederick MD, US
Kent L. Anderson - Houston TX, US
Michael Dean - Frederick MD, US
Mark Leppert - Salt Lake City UT, US
Richard A. Lewis - Houston TX, US
Yixin Li - Houston TX, US
James R. Lupski - Houston TX, US
Jeremy Nathans - Baltimore MD, US
Amir Rattner - Baltimore MD, US
Noah F. Shroyer - Houston TX, US
Nanda Singh - Salt Lake City UT, US
Philip Smallwood - Woodbine MD, US
Hui Sun - Baltimore MD, US

Assignee:

University of Utah Research Foundation - Salt Lake City UT
Baylor College of Medicine - Houston TX
John Hopkins University - Baltiomore MD
The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C12N 5/00
C12N 15/00
C12N 15/63
C07H 21/02
C07H 21/04
C12P 21/06
C07K 1/00

US Classification:

435325, 435 691, 4353201, 435455, 536 231, 536 235, 530350

Abstract:

The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.

US Patent:

7189511, Mar 13, 2007

Filed:

Jan 3, 2003

Appl. No.:

10/336215

Inventors:

Rando Allikmets - Frederick MD, US
Kent L. Anderson - Houston TX, US
Michael Dean - Frederick MD, US
Mark Leppert - Salt Lake City UT, US
Richard A. Lewis - Houston TX, US
Yixin Li - Houston TX, US
James R. Lupski - Houston TX, US
Jeremy Nathans - Baltimore MD, US
Amir Rattner - Baltimore MD, US
Noah F. Shroyer - Houston TX, US
Nanda Singh - Salt Lake City UT, US
Philip Smallwood - Woodbine MD, US
Hui Sun - Baltimore MD, US

Assignee:

Baylor College of Medicine - Houston TX
The United States of America as represented by the Department of Health and Human Services - Washington DC
University of Utah Research Foundation - Salt Lake City UT
John Hopkins University - Baltimore MD

International Classification:

C12Q 1/68
C12Q 1/00
C07H 21/02
C07H 21/04
C12P 21/06

US Classification:

435 6, 435 4, 435 691, 536 231, 536 235, 536 243, 536 2433

Abstract:

The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.

US Patent:

7192579, Mar 20, 2007

Filed:

Jan 3, 2003

Appl. No.:

10/336219

Inventors:

Rando Allikmets - Frederick MD, US
Kent L. Anderson - Houston TX, US
Michael Dean - Frederick MD, US
Mark Leppert - Salt Lake City UT, US
Richard A. Lewis - Houston TX, US
Yixin Li - Houston TX, US
James R. Lupski - Houston TX, US
Jeremy Nathans - Baltimore MD, US
Amir Rattner - Baltimore MD, US
Noah F. Shroyer - Houston TX, US
Nanda Singh - Salt Lake City UT, US
Philip Smallwood - Woodbine MD, US
Hui Sun - Baltimore MD, US

Assignee:

Baylor College of Medicine - Houston TX
Johns Hopkins University - Baltimore MD
University of Utah Research Foundation - Salt Lake City UT
United States of America, Represented by the Secretary, Department of Health and Human Services, c/o National Institute of Health - Washington DC

International Classification:

A01N 63/00
A01N 43/04
C12P 21/06
C12N 5/00
C12N 15/00
C12N 15/63
C07H 21/04

US Classification:

424 931, 424 932, 435 691, 4353201, 435325, 435455, 514 44, 536 231, 536 235

Abstract:

The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.

US Patent:

8129353, Mar 6, 2012

Filed:

Dec 11, 2006

Appl. No.:

11/636909

Inventors:

Rando Allikmets - Frederick MD, US
Kent L. Anderson - Houston TX, US
Michael Dean - Frederick MD, US
Mark Leppert - Salt Lake City UT, US
Richard A. Lewis - Houston TX, US
Yixin Li - Houston TX, US
James R. Lupski - Houston TX, US
Jeremy Nathans - Baltimore MD, US
Amir Rattner - Baltimore MD, US
Noah F. Shroyer - Houston TX, US
Nanda Singh - Salt Lake City UT, US
Philip Smallwood - Woodbine MD, US
Hui Sun - Baltimore MD, US

Assignee:

Baylor College of Medicine - Houston TX
John Hopkins University - Baltimore MD
The United States of America as represented by the Secretary, Department of Health and Human Services - Washington DC
University of Utah Research Foundation - Salt Lake City UT

International Classification:

A61K 48/00
A61K 38/43
C07H 21/02

US Classification:

514 44R, 536 231, 424 941

Abstract:

The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.

US Patent:

20120040456, Feb 16, 2012

Filed:

Jun 2, 2011

Appl. No.:

13/151375

Inventors:

Rando Allikmets - Frederick MD, US
Kent L. Anderson - Houston TX, US
Michael Dean - Frederick MD, US
Mark Leppert - Salt Lake City UT, US
Richard A. Lewis - Houston TX, US
Yixin Li - Houston TX, US
James R. Lupski - Houston TX, US
Jeremy Nathans - Baltimore MD, US
Amir Rattner - Baltimore MD, US
Noah F. Shroyer - Houston TX, US
Nanda Singh - Salt Lake City UT, US
Philip Smallwood - Woodbine MD, US
Hui Sun - Baltimore MD, US

Assignee:

Baylor College of Medicine - Houston TX

International Classification:

C12N 1/21
C12N 15/11
C12N 15/63
C12N 5/10
C12N 1/19

US Classification:

435348, 435349, 435358, 435363, 435367, 4352523, 43525231, 43525233, 43525234, 4352542, 43525421, 4353201, 536 231

Abstract:

The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.

US Patent:

20130137130, May 30, 2013

Filed:

May 6, 2011

Appl. No.:

13/695887

Inventors:

James M. Wells - Cincinnati OH, US
Jason R. Spence - Cincinnati OH, US
Aaron M. Zorn - Cincinnati OH, US
Noah F. Shroyer - Cincinnati OH, US

Assignee:

CHILDREN'S HOSPITAL MEDICAL CENTER - Cincinnati OH

International Classification:

C12N 5/071

US Classification:

435 29, 435377

Abstract:

The generation of complex organ tissues from human embryonic and pluripotent stem cells (PSCs) remains a major challenge for translational studies. It is shown that PSCs can be directed to differentiate into intestinal tissue in vitro by modulating the combinatorial activities of several signaling pathways in a step-wise fashion, effectively recapitulating in vivo fetal intestinal al development. The resulting intestinal “organoids” were three-dimensional structures consisting of a polarized, columnar epithelium surrounded by mesenchyme that included a smooth muscle-like layer. The epithelium was patterned into crypt-like SOX9-positive proliferative zones and villus-like structures with all of the major functional cell types of the intestine. The culture system is used to demonstrate that expression of NEUROG3, a pro-endocrine transcription factor mutated in enteric anendocrinosis is sufficient to promote differentiation towards the enteroendocrine cell lineage. In conclusion, PSC-derived human intestinal tissue should allow for unprecedented studies of human intestinal development, homeostasis and disease.

US Patent:

6713300, Mar 30, 2004

Filed:

Feb 27, 1998

Appl. No.:

09/032438

Inventors:

Rando Allikmets - Frederick MD
Kent L. Anderson - Houston TX
Michael Dean - Frederick MD
Mark Leppert - Salt Lake City UT
Richard A. Lewis - Houston TX
Yixin Li - Houston TX
James R. Lupski - Houston TX
Jeremy Nathans - Baltimore MD
Amir Rattner - Baltimore MD
Noah F. Shroyer - Houston TX
Nanda Singh - Salt Lake City UT
Philip Smallwood - Woodbine MD
Hui Sun - Baltimore MD

Assignee:

University of Utah Research Foundation - Salt Lake City UT
Baylor College of Medicine - Houston TX
Johns Hopkins University - Baltimore MD
The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C12N 1500

US Classification:

435325, 435 691, 4353201, 435455, 536 231, 536 235

Abstract:

The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.

US Patent:

20200269230, Aug 27, 2020

Filed:

Oct 26, 2018

Appl. No.:

16/757577

Inventors:

- Houston TX, US
Reid Laurence Wilson - Houston TX, US
Christopher Stewart - Houston TX, US
Joseph Petrosino - Houston TX, US
Robert Allen Britton - Houston TX, US
Jane Grande-Allen - Houston TX, US
Noah F. Shroyer - Houston TX, US
Mary K. Estes - Houston TX, US

International Classification:

B01L 1/02
B01L 3/00
C12Q 1/18
C12Q 1/70
G01N 33/50

Abstract:

An anaerobic chamber system to evaluate human enteric disease is described herein that can be used to test therapeutic components. In specific embodiments, the anaerobic chamber is used to determine the effect of one or more bacterial communities on ex vivo enteroid cultures. In one application, the anaerobic chamber system is used to determine the efficacy of therapeutic components in ameliorating human enteric disease using personalized medicine.