Noriaki Tatsuta

US Patent:

6458406, Oct 1, 2002

Filed:

Jan 21, 2000

Appl. No.:

09/489059

Inventors:

Mitsunori Ono - Lexington MA 02420
Keizo Koya - Brookline MA 02446
Noriaki Tatsuta - Lexington MA 02420
Naoto Yamaguchi - Lexington MA 02421
Lan Bo Chen - Lexington MA 02420

International Classification:

A23L 120

US Classification:

426634, 426629, 426655, 426539, 426594, 426599, 426590, 426 3, 426631

Abstract:

This invention relates to a water-soluble bean-based extract including one or more isoflavone glycosides. Also included is a method of preparing such a water-soluble bean-based extract.

US Patent:

6541062, Apr 1, 2003

Filed:

Dec 18, 2000

Appl. No.:

09/739067

Inventors:

Mitsunori Ono - Lexington MA 02420
Keizo Koya - Brookline MA 02446
Noriaki Tatsuta - Lexington MA 02420
Naoto Yamaguchi - Lexington MA 02421
Lan Bo Chen - Lexington MA 02420

International Classification:

A23L 128

US Classification:

426655, 426431, 426589, 426594, 426597, 426599, 426590, 426 3, 426631, 426634

Abstract:

This invention relates to a water-soluble soybean-based extract including one or more isoflavone glycosides. Also described is a method of preparing such a water-soluble soybean-based extract.

US Patent:

6616959, Sep 9, 2003

Filed:

Nov 13, 2001

Appl. No.:

10/006326

Inventors:

Mitsunori Ono - Lexington MA 02420
Keizo Koya - Brookline MA 02446
Noriaki Tatsuta - Lexington MA 02420
Naoto Yamaguchi - Lexington MA 02421
Lan Bo Chen - Lexington MA 02420

International Classification:

A23L 120

US Classification:

426431, 426634, 426629, 426655, 426590

Abstract:

This invention relates to a water-soluble bean-based extract including one or more isoflavone glycosides. Also shown is a method of preparing such a water-soluble bean-based extract.

US Patent:

6762204, Jul 13, 2004

Filed:

Jul 10, 2002

Appl. No.:

10/193639

Inventors:

Keizo Koya - Brookline MA
Lijun Sun - Harvard MA
Shoujun Chen - Billerica MA
Noriaki Tatsuta - Lexington MA
Yaming Wu - Lexington MA
Mitsunori Ono - Lexington MA
Zhi-Qiang Xia - Dedham MA

Assignee:

Synta Pharmaceuticals, Inc. - Lexington MA

International Classification:

A61K 3116

US Classification:

514599, 564148, 564149, 564151

Abstract:

One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both C Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or âC(R R )â. R is an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, or a substituted non-aromatic heterocyclic group, R -R are independently âH, an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, a substituted non-aromatic heterocyclic group, an aryl group or a substituted aryl group, or R and R taken together with the carbon and nitrogen atoms to which they are bonded, and/or R and R taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. R -R are independently âH, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R and R are each independently âH, an aliphatic or substituted aliphatic group, or R is âH and R is a substituted or unsubstituted aryl group, or, R and R , taken together, are a C2-C6 substituted or unsubstituted alkylene group.

US Patent:

6800660, Oct 5, 2004

Filed:

Jul 10, 2002

Appl. No.:

10/193075

Inventors:

Keizo Koya - Brookline MA
Lijun Sun - Harvard MA
Shoujun Chen - Billerica MA
Noriaki Tatsuta - Lexington MA
Yaming Wu - Lexington MA
Mitsunori Ono - Lexington MA

Assignee:

Synta Pharmaceuticals Corp. - Lexington MA

International Classification:

A61K 3116

US Classification:

514614, 514615, 564148, 564149

Abstract:

Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both C Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or âC(R R )â. R and R are independently an aryl group or a substituted aryl group, R and R are independently âH, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R -R are independently âH, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R and R are each independently âH, an aliphatic or substituted aliphatic group, or R is âH and R is a substituted or unsubstituted aryl group, or, R and R , taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is O or S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent.

US Patent:

6924312, Aug 2, 2005

Filed:

Jan 15, 2003

Appl. No.:

10/345885

Inventors:

Keizo Koya - Chestnut Hill MA, US
Lijun Sun - Harvard MA, US
Shoujun Chen - Bedford MA, US
Noriaki Tatsuta - Lexington MA, US
Yaming Wu - Lexington MA, US
Mitsunori Ono - Lexington MA, US

Assignee:

Synta Pharmaceuticals Corp. - Lexington MA

International Classification:

A61K031/16
C07C241/00

US Classification:

514614, 514615, 564148, 564149

Abstract:

Disclosed is a compound represented by the Structural Formula (I): Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with taxol or an analog of taxol.

US Patent:

7001923, Feb 21, 2006

Filed:

Mar 18, 2004

Appl. No.:

10/803798

Inventors:

Keizo Koya - Brookline MA, US
Lijun Sun - Harvard MA, US
Shoujun Chen - Billerica MA, US
Noriaki Tatsuta - Lexington MA, US
Yaming Wu - Lexington MA, US
Mitsunori Ono - Lexington MA, US
Zhi-Qiang Xia - Dedham MA, US

Assignee:

Synta Pharmaceuticals Corp. - Lexington MA

International Classification:

A61K 31/16
A61K 31/335
C07C 327/00
C07D 305/00

US Classification:

514599, 514449, 564 74, 549510

Abstract:

One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C=Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(RR)—. Ris an aliphatic group, a substituted aliphatic group, a non-aromatic hetereocyclic group, or a substituted non-aromatic hetereocyclic group, R–Rare independently —H, an aliphatic group, a substituted aliphatic group, a non-aromatic hetereocyclic group, a substituted non-aromatic hetereocyclic group, an aryl group or a substituted aryl group, or Rand Rtaken together with the carbon and nitrogen atoms to which they are bonded, and/or Rand Rtaken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. R–Rare independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. Rand Rare each independently —H, an aliphatic or substituted aliphatic group, or Ris —H and Ris a substituted or unsubstituted aryl group, or, Rand R, taken together, are a C2–C6 substituted or unsubstituted alkylene group.

US Patent:

7037940, May 2, 2006

Filed:

May 14, 2004

Appl. No.:

10/846152

Inventors:

Keizo Koya - Brookline MA, US
Lijun Sun - Harvard MA, US
Shoujun Chen - Billerica MA, US
Noriaki Tatsuta - Lexington MA, US
Yaming Wu - Lexington MA, US
Mitsunori Ono - Lexington MA, US

Assignee:

Synta Pharmaceuticals Corp. - Lexington MA

International Classification:

A61K 31/16
A61K 31/335
C07C 327/00
C07D 305/00

US Classification:

514599, 514449, 564 74, 549510

Abstract:

Disclosed is a compound represented by the Structural Formula (I):.