Norman A Block

US Patent:

6429204, Aug 6, 2002

Filed:

Apr 3, 2000

Appl. No.:

09/542402

Inventors:

Lorne M. Golub - Smithtown NY
Thomas F. McNamara - Morristown NY
Nungavaram S. Ramamurthy - Smithtown NY
Hsi-Ming Lee - Setauket NY
Sanford Simon - Stony Brook NY
Balakrishna L. Lokeshwar - Miami FL
Marie G. Selzer - Fort Lauderdale FL
Norman L. Block - Miami FL

Assignee:

University of Miami - Miami FL

International Classification:

A61K 3165

US Classification:

514152, 514153

Abstract:

The invention is a method of inhibiting a sarcoma, such as Kaposis sarcoma, in a mammal. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3. ).

US Patent:

8507433, Aug 13, 2013

Filed:

Oct 28, 2010

Appl. No.:

12/914023

Inventors:

Andrew V. Schally - Miami Beach FL, US
Norman L Block - Hollywood FL, US
Joshua Hare - Miami Beach FL, US
Rosemeire Miyuki Kanashiro Takeuchi - Miami FL, US

Assignee:

University of Miami - Miami FL
The United States of America, represented by the Deptartment of Veterans Affairs - Washington DC

International Classification:

A61K 38/25
C07K 14/60
A61P 9/10

US Classification:

514 112, 514 151, 514 213, 530324, 930120

Abstract:

Whether the growth hormone (GH)/Insulin-like growth factor 1(IGF-I) axis exerts cardioprotective effects remains controversial; and the underlying mechanism(s) for such actions are unclear. Here we tested the hypothesis that growth-hormone releasing hormone (GHRH) directly activates cellular reparative mechanisms within the injured heart, in a GH/IGF-I independent fashion. Following experimental myocardial infarction (MI), rats were randomly assigned to receive, during a 4 week period, either placebo (n=14), rat recombinant GH (rrGH, n=8) or JI-38 (n=8; 50 μg/Kg/day), a potent GHRH-agonist. JI-38 did not elevate serum levels of GH or IGF-I, but markedly attenuated the degree of cardiac functional decline and remodeling after injury. In contrast, GH administration markedly elevated body weight, heart weight, circulating GH and IGF-I, but did not offset the decline in cardiac structure and function. Whereas, both JI-38 and GH augmented levels of cardiac precursor cell proliferation, only JI-38 increased anti-apoptotic gene expression.

US Patent:

20100092539, Apr 15, 2010

Filed:

Sep 17, 2009

Appl. No.:

12/562096

Inventors:

Andrew Schally - Miami Beach FL, US
Jozsef Varga - Miami Beach FL, US
Marta Zarandi - Miami Beach FL, US
Ren Zhi Cai - Miami FL, US
Norman L. Block - Hollywood FL, US

International Classification:

A61F 2/00
C07K 14/00
A61K 38/16
A61P 35/04

US Classification:

424423, 530324, 514 12

Abstract:

Novel fluorinated synthetic analogs of hGH-RH(1-30)NHthat inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers through a direct effect on the cancer cells, and to therapeutic compositions containing these novel peptides and their use.

US Patent:

20110066230, Mar 17, 2011

Filed:

Sep 17, 2009

Appl. No.:

12/562010

Inventors:

Andrew Schally - Miami Beach FL, US
Jozsef Varga - Miami Beach FL, US
Marta Zarandi - Miami Beach FL, US
Ren Zhi Cai - Miami FL, US
Norman L. Block - Hollywood FL, US

International Classification:

A61F 2/82
C07K 14/00
A61K 38/16
A61P 9/10
A61P 35/00

US Classification:

623 146, 530324, 514 193, 514 213

Abstract:

Novel fluorinated synthetic analogs of hGH-RH(1-30)NHthat inhibit the release of growth hormone from the pituitary in mammals as well as inhibit the proliferation of human cancers through a direct effect on the cancer cells, and to therapeutic compositions containing these novel peptides and their use.

US Patent:

20130195807, Aug 1, 2013

Filed:

Jun 3, 2011

Appl. No.:

13/701498

Inventors:

Andrew V. Schally - Miami FL, US
Barbara Ludwig - Dresden, DE
Stefan Bornstein - Dresden, DE
Norman L. Block - Miami FL, US

International Classification:

C07K 14/60
A61K 38/25
A61K 35/12

US Classification:

424 937, 435375, 514 67, 514 69, 514 112, 530399

Abstract:

Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.

US Patent:

20130261058, Oct 3, 2013

Filed:

Sep 16, 2011

Appl. No.:

13/823729

Inventors:

Andrew V. Schally - Miami FL, US
Hippokratis Kiaris - Athens, GR
Norman L. Block - Miami FL, US

Assignee:

University of Miami - Miami FL
U.S. Department of Veterans Affairs - Washington DC
National and Kapodistrian University of Athens - Athens

International Classification:

A61K 38/25
A61K 38/16

US Classification:

514 112

Abstract:

Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.

US Patent:

61002488, Aug 8, 2000

Filed:

Jan 15, 1998

Appl. No.:

9/007645

Inventors:

Lorne M. Golub - Smithtown NY
Thomas F. McNamara - Port Jefferson NY
Nungavaram S. Ramamurthy - Smithtown NY
Hsi-Ming Lee - Setauket NY
Sanford Simon - Stony Brook NY
Balakrishna L. Lokeshwar - Miami FL
Marie G. Selzer - Fort Lauderdale FL
Norman L. Block - Miami FL

International Classification:

A01N 3718

US Classification:

514152

Abstract:

The invention is a method of inhibiting cancer growth, by inhibiting cellular proliferation, invasiveness, or metastasis, or by inducing cytotoxicity against cancer in mammals. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.

US Patent:

58376968, Nov 17, 1998

Filed:

Jan 15, 1997

Appl. No.:

8/783655

Inventors:

Lorne M. Golub - Smithtown NY
Thomas F. McNamara - Port Jefferson NY
Nungavaram S. Ramamurthy - Smithtown NY
Hsi-Ming Lee - Setauket NY
Sanford Simon - Stony Brook NY
Balakrishna L. Lokeshwar - Miami FL
Marie G. Selzer - Fort Lauderdale FL
Norman L. Block - Miami FL

Assignee:

The Research Foundation of State University of New York - Albany NY
University of Miami - Miami FL

International Classification:

A01N 3718
A61K 3165

US Classification:

514152

Abstract:

The invention is a method of inhibiting cancer growth, including cellular proliferation, invasiveness, or metastasis in mammals. The method employs 6-demethyl-6-deoxy-4-dedimethylaminotetracycline (CMT-3) and other functionally related chemically modified, preferably non-antibacterial, tetracycline compounds to inhibit cancer growth. The method is particularly effective to inhibit the establishment, growth, and metastasis of solid tumors, such as tumors derived from colon cancer cells, breast cancer cells, melanoma cells, prostatic carcinoma cells, or lung cancer cells.