Norman J Haughey from 5807 Roland Ave, Baltimore, MD 21210, age 58, Phone: 4103234447

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Compositions And Methods For Neuroprotectin
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US Patent:

20080090897, Apr 17, 2008
Filed:

Aug 13, 2007
Appl. No.:

11/893100
Inventors:

Joseph Steiner - Mount Airy MD, US
Avindra Nath - Ellicott City MD, US
Norman Haughey - Baltimore MD, US
Assignee:

The Johns Hopkins University - Baltimore MD
International Classification:

A61K 31/366
US Classification:

514453000, 514456000, 514460000, 514454000
Abstract:

Disclosed herein are neuroprotective compounds. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of neurodegenerative conditions are provided.

Role Of Limonoid Compounds As Neuroprotective Agents
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US Patent:

20100056617, Mar 4, 2010
Filed:

Nov 5, 2009
Appl. No.:

12/590270
Inventors:

Joseph P. Steiner - Baltimore MD, US
Avindra Nath - Ellicott City MD, US
Norman Haughey - Baltimore MD, US
Assignee:

The Johns Hopkins University - Baltimore MD
International Classification:

A61K 31/35
A61P 25/18
A61P 25/28
US Classification:

514453
Abstract:

Disclosed herein are neuroprotective compounds. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of neurodegenerative conditions are provided.

Methods And Compositions For Diagnosis And Treatment Of Multiple Sclerosis
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US Patent:

20100137420, Jun 3, 2010
Filed:

Sep 19, 2007
Appl. No.:

11/857742
Inventors:

Avindra Nath - Baltimore MD, US
Caroline F. Anderson - Columbia MD, US
David Irani - Baltimore MD, US
Robert J. Cotter - Baltimore MD, US
Joseph P. Steiner - Mount Airy MD, US
Norman Haughey - Baltimore MD, US
International Classification:

G01N 33/53
C07K 16/18
A61K 31/352
US Classification:

514453, 435 792, 435 79, 5303879
Abstract:

Biological markers for multiple sclerosis, and their use in the diagnosis and prognosis of the disease, are described. Also described are methods for treating multiple sclerosis by administering an inhibitor of cathepsin B activity or a neuroprotective composition comprising a modified terpenoid compound. Also described are isolated polypeptide biomarkers, polynucleotides encoding the polypeptide biomarkers, and antibodies that bind specifically to the polypeptide biomarkers. Further described are kits that include the above-mentioned isolated polypeptide biomarkers, the polynucleotides encoding them, or specific antibodies against the polypeptide biomarkers.

Antifungal Agents As Neuroprotectants
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US Patent:

20100298394, Nov 25, 2010
Filed:

Jun 14, 2010
Appl. No.:

12/815014
Inventors:

Joseph P. Steiner - Baltimore MD, US
Avindra Nath - Ellicott City MD, US
Norman Haughey - Baltimore MD, US
Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:

A61K 31/4196
A61K 31/4164
C07D 233/60
C07D 249/08
A61P 25/28
A61P 25/02
A61P 25/04
A61P 25/16
A61P 9/10
US Classification:

514383, 514399, 5483421, 5482666
Abstract:

Provided herein are compounds, compositions and methods for protecting neuronal and glial cells.

2,6-Dimethoxy-4-(5-Phenyl-4-Thiophene-2-Yl-1H-Imidazol-2-Yl)-Phenol (Dptip) A Small Molecule Inhibitor Of Neutral Sphingomyelinase 2 (Nsmase-2) For The Treatment Of Neurodegenerative And Oncologic Diseases
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US Patent:

20210000798, Jan 7, 2021
Filed:

Mar 1, 2019
Appl. No.:

16/977305
Inventors:

- Baltimore MD, US
- Bethesda MD, US
Ajit G. Thomas - Baltimore MD, US
Norman Haughey - Baltimore MD, US
International Classification:

A61K 31/4178
A61P 25/28
Abstract:

Methods for treating one or more diseases associated with neutral sphingomyelinase 2 (nSMase2) in a subject in need of treatment thereof, the method comprising administering to the subject a therapeutically effective amount of 2,6-dimethoxy-4-(5-phenyl-4-thiophen-2-yl-1H-imidazol-2-yl)-phenol (DPTIP) or a pharmaceutically acceptable salt thereof, are disclosed.

Detection Of Hiv-1-Associated Neurocognitive Disorders
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US Patent:

20170176408, Jun 22, 2017
Filed:

Mar 24, 2015
Appl. No.:

15/129353
Inventors:

- Philadelphia PA, US
- Baltimore MD, US
Kamel Khalili - Bala Cynwyd PA, US
Jay Rappaport - Somers Point NJ, US
Norman J. Haughey - Baltimore MD, US
Ned Sacktor - Baltimore MD, US
International Classification:

G01N 33/487
G01N 30/88
Abstract:

Provided is a method of detecting mild neurocognitive disturbance (MNCD) or HIV associated dementia (HAD) in a patient comprising detecting the level of acetyl spermine and/or acetyl spermidine from a cerebrospinal fluid test sample of the patient; and comparing the level of acetyl spermine and/or acetyl spermidine in the test sample to the level of the acetyl spermine and/or acetyl spermidine in a cerebrospinal fluid control sample or to a control value for lack of neurocognitive impairment, MNCD or HAD; wherein an elevated level of acetyl spermine and/or acetyl spermidine in the test sample as compared to the level in the control sample or a control value for lack of neurocognitive impairment, or a level of acetyl spermine and/or acetyl spermidine that is similar to that of a control value for MNCD or HAD, indicates that the patient suffers from MNCD or HAD. Also provided are methods for measuring the progression of an HIV-1-associated neurocognitive disorder, as well as methods for staging such a disorder.