Massachusetts Institute of Technology (Mit)
Mcgovern Institute Fellow
Broad Institute May 2014 - Jan 2019
Medical Doctor and Phd Student In Feng Zhang's Lab
Sherlock Biosciences May 2014 - Jan 2019
Co-Founder
Modalyst Apr 2012 - Mar 2013
Co-Founder and Vice President of Engineering
Education:
Harvard Medical School 2012 - 2019
Doctor of Medicine, Doctorates, Doctor of Philosophy, Biomedical Engineering, Bioengineering
Massachusetts Institute of Technology 2014 - 2018
Doctorates, Doctor of Philosophy, Physics, Medical Engineering, Philosophy
Massachusetts Institute of Technology 2008 - 2012
Bachelors, Bachelor of Science, Biological Engineering, Mechanical Engineering
Harvard University
Portage Central High School
Kalamazoo Area Mathematics and Science Center
Skills:
Genetics Biomedical Engineering Matlab Nanotechnology Python Biotechnology Lifesciences Systems Biology
Interests:
Genetics The Killers (Band) Systems Biology Molecular Engineering Coldplay (Band) Kvcc Cancer Nanotechnology
The present disclosure provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides mutated Cas13 proteins and their use in modifying target sequences as well as mutated Cas13 nucleic acid sequences and vectors encoding mutated Cas13 proteins and vector systems or CRISPR-Cas13 systems.
Crispr Effector System Based Coronavirus Diagnostics
Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.
- Cambridge MA, US - New Brunswick NJ, US - Moscow, RU - Bethesda MD, US Leonid Minakhin - New Brunswick MD, US Kira S. Makarova - Bethesda MD, US Silvana Konermann - Cambridge MA, US Julia Joung - Cambridge MA, US Jonathan S. Gootenberg - Cambridge MA, US Omar O. Abudayyeh - Cambridge MA, US
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
- Cambridge MA, US - New Brunswick NJ, US - Moscow, RU - Bethesda MD, US Leonid Minakhin - New Brunswick MD, US Kira S. Makarova - Bethesda MD, US Silvana Konermann - Cambridge MA, US Julia Joung - Cambridge MA, US Jonathan S. Gootenberg - Cambridge MA, US Omar O. Abudayyeh - Cambridge MA, US
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
Feng Zhang - Cambridge MA, US Jonathan Gootenberg - Cambridge MA, US Omar Abudayyeh - Cambridge MA, US Julia Joung - Cambridge MA, US Alim Ladha - Cambridge MA, US Guilhem Faure - Cambridge MA, US
International Classification:
C12N 9/22 C12N 9/12 C12N 9/78
Abstract:
Engineered or non-naturally occurring systems and compositions comprising a novel Cas12b and a guide molecule. Also provided include methods of use the systems and compositions, including in treating and diagnosing diseases.
Feng Zhang - Cambridge MA, US Jonathan Gootenberg - Cambridge MA, US Omar Abudayyeh - Cambridge MA, US Julia Joung - Cambridge MA, US Alim Ladha - Cambridge MA, US Guilhem Faure - Cambridge MA, US
International Classification:
C12Q 1/6844 B01L 7/00 B01L 3/00
Abstract:
Systems and methods for rapid diagnostics related to the use of isothermal amplification reagents for detection of microbial species, including coronavirus, and methods of use, are provided.
Omar Abudayyeh 12, PhD 18, a recent McGovern Fellow at the McGovern Institute for Brain Research at MIT who is now an assistant professor at Harvard Medical School, shares an equally riveting story about his vanity plate, CRISPR, which adorns his sport utility vehicle.
Date: Jul 22, 2024
Category: Science
Source: Google
CRISPR 2.0: a new wave of gene editors heads for clinical trials
This opens the door to replacing entire genes, says Omar Abudayyeh, a biological engineer at the Massachusetts Institute of Technology in Cambridge thereby making it easier to develop a therapy to treat genetic disorders, such as cystic fibrosis, that can be caused by many different mutations in
Date: Dec 07, 2023
Category: Health
Source: Google
Thousands of programmable DNA-cutters found in algae, snails, and other organisms
RNA-guided biology is what lets you make programmable tools that are really easy to use. So the more we can find, the better, says McGovern Fellow Omar Abudayyeh, who led the research with McGovern Fellow Jonathan Gootenberg.
Date: Oct 13, 2023
Category: Science
Source: Google
CRISPR-based Covid-19 test could be a simple, cheap diagnostic
ing in the U.S. It takes about an hour to get results, requires minimal handling, and in preliminary studies has been highly accurate, Zhang told STAT. He and his colleagues, led by the McGoverns Jonathan Gootenberg and Omar Abudayyeh, released the protocol on their STOPCovid.science website.
Date: May 05, 2020
Category: More news
Source: Google
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