Omar F Laterza

US Patent:

8481277, Jul 9, 2013

Filed:

Aug 21, 2008

Appl. No.:

12/674153

Inventors:

Jack H. Ladenson - St. Louis MO, US
Omar Laterza - New York NY, US
Vijay Modur - Acton MA, US

Assignee:

Washington University - St. Louis MO

International Classification:

G01N 33/53
G01N 33/567
G01N 33/566

US Classification:

435 792, 435 71, 435 721, 435 78, 435 79, 436501, 436503

Abstract:

Evaluation of VLP-I levels in combination with at least one of amyloid-β peptide (AB), hyperphosphorylated tau (pTau) or total tau (tTau) levels in samples of biological fluid improves the accuracy of diagnosis of Alzheimer's disease.

US Patent:

20110111976, May 12, 2011

Filed:

Apr 24, 2009

Appl. No.:

12/989246

Inventors:

Thomas L. Fare - Furlong PA, US
Philip W. Garrett-Engele - Needham MA, US
Warren E. Glaab - Doylestown PA, US
Jason M. Johnson - Needham MA, US
Omar F. Laterza - New York NY, US
Lee Lim - San Francisco CA, US
Steve W. Ludmerer - North Wales PA, US
David B. Olsen - Lansdale PA, US
Joseph F. Sina - Maple Glen PA, US
Frank D. Sistare - Collegeville PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C40B 30/04
C12Q 1/68
G01N 33/53

US Classification:

506 9, 435 6, 436 94

Abstract:

One aspect of the invention generally relates to use of tissue enriched miRNAs as biomarker to estimate tissue damage in a fluid sample. In a second aspect, methods are provided for monitoring a subject who is exposed or might have been exposed to an agent that has a risk of causing tissue injury. In a third aspect, methods are provided for identifying an agent as having a risk of causing tissue injury to a vertebrate subject. In a fourth aspect, kits are provided for practicing the methods of above-listed aspects. The contents of this ABSTRACT are not intended to in anyway limit the scope of the inventions claimed herein.

US Patent:

20130288280, Oct 31, 2013

Filed:

Jun 27, 2013

Appl. No.:

13/929600

Inventors:

Omar LATERZA - New York NY, US
Vijay MODUR - Acton MA, US

International Classification:

G01N 33/68

US Classification:

435 794, 436501, 435 792

Abstract:

Evaluation of VLP-1 levels in combination with at least one of amyloid-β peptide (Aβ), hyperphosphorylated tau (pTau) or total tau (tTau) levels in samples of biological fluid improves the accuracy of diagnosis of Alzheimer's disease.

US Patent:

20160069900, Mar 10, 2016

Filed:

Sep 2, 2015

Appl. No.:

14/843285

Inventors:

Gulesi Ayanoglu - Palo Alto CA, US
Xiaoyan Du, JR. - Burlingame CA, US
Vinita Gupta - Edison NJ, US
Omar Laterza - New York NY, US
Linda Liang - Mountainview CA, US
Eric Rimmer - Pacifica CA, US

International Classification:

G01N 33/68
G01N 33/574

Abstract:

The present disclosure describes two matched antibody pairs for use in a sandwich immunoassay for detecting and quantifying soluble PD-L1 in liquid samples, as well as an electrochemiluminescence sandwich immunoassay that has been optimized and validated with one of the matched pairs.

US Patent:

20150253341, Sep 10, 2015

Filed:

Feb 6, 2015

Appl. No.:

14/615480

Inventors:

- Rahway NJ, US
Michael E. Lassman - Scotch Plains NJ, US
Omar F. Laterza - New York NY, US

Assignee:

MERCK SHARP & DOHME CORP. - Rahway NJ

International Classification:

G01N 33/68
C07K 14/47

Abstract:

The present invention provides a quantitative immunoaffinity LC-MS/MS assay for detection and quantification of Tau protein in a biological sample.