Pamala M Gahr

US Patent:

6835818, Dec 28, 2004

Filed:

Jul 14, 1999

Appl. No.:

09/308829

Inventors:

Patrick M. Schlievert - Edina MN
Douglas Ohlendorf - Eden Prairie MN
David T. Mitchell - Vadnais Heights MN
Pamala J. Gahr - Woodbury MN

Assignee:

Regents of the University of Minnesota - Minneapolis MN

International Classification:

A01N 6300

US Classification:

5303884, 424 9344, 4241651, 4241831, 4241841, 4241901, 4242001, 4242031, 4242361, 4242371, 4242441, 424832, 435 731, 435 734, 435 36, 435 693, 4352534, 435340, 930200

Abstract:

This invention is directed to mutant SPE-C toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-C toxin has at least one amino acid change and is substantially non-lethal compared with the wild type SPE-C toxin. The mutant SPE-C toxins can form vaccine compositions useful to protect animals against the biological activities of wild type SPE-C toxin.