Pamela A Lane

US Patent:

20010014458, Aug 16, 2001

Filed:

Mar 1, 2001

Appl. No.:

09/796965

Inventors:

Nabil Elshourbagy - West Chester PA, US
Pamela Lane - Norristown PA, US
Ping Tsui - Berwyn PA, US

International Classification:

A61K038/00
A61K031/70
A01N043/04
C12P021/06

US Classification:

435/007210, 435/006000, 435/069100, 514/012000, 514/044000

Abstract:

GPR6sb polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing GPR6sb polypeptides and polynucleotides in therapy, and diagnostic assays for such.

US Patent:

20020045214, Apr 18, 2002

Filed:

Mar 20, 2001

Appl. No.:

09/812272

Inventors:

Nabil Elshourbagy - West Chester PA, US
Pamela Lane - Norristown PA, US
Ping Tsui - Berwyn PA, US

International Classification:

C12P021/02
C12N005/06
C07K014/705
C07H021/04

US Classification:

435/069100, 435/325000, 530/350000, 536/023500

Abstract:

Rattus norvegus AXOR29 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize rattus norvegus AXOR29. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome.

US Patent:

20020045216, Apr 18, 2002

Filed:

Jun 12, 2001

Appl. No.:

09/879017

Inventors:

Nabil Elshourbagy - West Chester PA, US
Pamela Lane - Harleysville PA, US
Ping Tsui - Berwyn PA, US

International Classification:

C07K014/705
C07H021/04
C12P021/02
C12N005/06

US Classification:

435/069100, 435/325000, 435/320100, 530/350000, 536/023500

Abstract:

Mus Musculus FMRL-3 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Mus Musculus FMRL-3. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome.

US Patent:

20020061558, May 23, 2002

Filed:

Jun 12, 2001

Appl. No.:

09/879225

Inventors:

Nabil Elshourbagy - West Chester PA, US
Pamela Lane - Harleysville PA, US
Ping Tsui - Berwyn PA, US

International Classification:

C12P021/02
C12N005/06
C07H021/04
C07K014/705

US Classification:

435/069100, 435/325000, 435/320100, 530/350000, 536/023500

Abstract:

Mus musculus EDG7 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Mus musculus EDG7. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome.

US Patent:

20020090691, Jul 11, 2002

Filed:

Jul 12, 2001

Appl. No.:

09/903799

Inventors:

Nabil Elshourbagy - West Chester PA, US
Pamela Lane - Harleysville PA, US
Ping Tsui - Berwyn PA, US

International Classification:

C12N009/00
C07H021/04
C12P021/02
C12N005/06

US Classification:

435/183000, 435/325000, 435/320100, 435/069100, 536/023200

Abstract:

Mus musculus EDG4 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize Mus musculus EDG4. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; diabetes, obesity; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; stroke; ulcers; asthma; allergies; benign prostatic hypertrophy; migraine; vomiting; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, depression, delirium, dementia, and severe mental retardation; and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome.

US Patent:

61803650, Jan 30, 2001

Filed:

Nov 6, 1998

Appl. No.:

9/187710

Inventors:

Nabil Elshourbagy - West Chester PA
Pamela Lane - Norristown PA
Ping Tsui - Berwyn PA
Lisa Vawter - Coopersburg PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12P 2106
C12P 2104
C12N 120
C12N 1500
C07H 2104

US Classification:

435 691

Abstract:

The mouse GPR43 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing mouse GPR43 polypeptides and polynucleotides in therapy, and diagnostic assays for such.