Pamela B Maher

US Patent:

8466195, Jun 18, 2013

Filed:

Mar 15, 2010

Appl. No.:

13/255192

Inventors:

Pamela A. Maher - La Jolla CA, US
David R. Schubert - La Jolla CA, US

Assignee:

Salk Institute for Biological Studies - La Jolla CA

International Classification:

A61K 31/353

US Classification:

514456

Abstract:

Disclosed herein, inter alia, are methods and compositions for treating a complication of diabetes or a vascular disease using a 5-desoxy-flavone and/or 5-desoxy-flavonol.

US Patent:

20080021096, Jan 24, 2008

Filed:

Jul 19, 2007

Appl. No.:

11/780350

Inventors:

Pamela A. Maher - La Jolla CA, US

International Classification:

A61K 31/352
A61P 25/00

US Classification:

514456

Abstract:

Described herein are flavonoids (e.g., 5-desoxy flavones and/or 5-desoxy flavonols, including without limitation fisetin and its derivatives) that activate ERK and induce CREB phosphorylation in neuronal cultures, facilitate long-term potentiation in hippocampal slices and enhance object recognition in vivo. Methods of using these flavonoids, for instance, for enhancing memory are described.

US Patent:

20160206609, Jul 21, 2016

Filed:

Feb 26, 2016

Appl. No.:

15/054906

Inventors:

- La Jolla CA, US
Pamela A. Maher - La Jolla CA, US
Chandramouli Chiruta - La Jolla CA, US

Assignee:

Salk Institute for Biological Studies - La Jolla CA

International Classification:

A61K 31/47
A61K 31/352
C07D 311/62
A61K 45/06
A61K 31/4025
C07D 215/233
A61K 31/4709
C07D 311/30
C07D 311/78

Abstract:

The present invention provides neuroprotective polyphenol compounds, which can be synthetic analogs of fisetin, baicalein or chlorogenic acid, that maintain neuroprotective, anti-inflammatory, glutathione promoting, and/or antioxidant properties. The neuroprotective polyphenol compounds are useful for promoting, enhancing and/or increasing neuron protection, growth and/or regeneration. The polyphenol compounds further find use for increasing and or maintaining intracellular glutathione (GSH) levels. The polyphenol compounds are also useful for treating, preventing, mitigating and/or delaying neurodegenerative conditions, including diabetes, Parkinson's disease, Huntington's disease, Alzheimer's disease, non-Alzheimer's dementias, multiple sclerosis, traumatic brain injury, spinal cord injury or ALS.

US Patent:

20140186328, Jul 3, 2014

Filed:

Feb 5, 2014

Appl. No.:

14/173658

Inventors:

- La Jolla CA, US
Pamela A. Maher - La Jolla CA, US
Chandramouli Chiruta - San Diego CA, US

Assignee:

Salk Institute for Biological Studies - La Jolla CA

International Classification:

C07D 311/60
A61K 31/352
A61K 45/06
C07D 311/62
A61K 31/353
A61K 31/4709
C07C 49/835
A61K 31/12
C07C 49/84
C07D 215/233
A61K 31/47
C07D 311/78
A61K 31/4025

US Classification:

424 9464, 549392, 514455, 424 9463, 549400, 514456, 549403, 548525, 514422, 568334, 514685, 568328, 514682, 546153, 514312

Abstract:

The present invention provides neuroprotective polyphenol compounds, which can be synthetic analogs of fisetin, baicalein or chlorogenic acid, that maintain neuroprotective, anti-inflammatory, glutathione promoting, and/or antioxidant properties. The neuroprotective polyphenol compounds are useful for promoting, enhancing and/or increasing neuron protection, growth and/or regeneration. The polyphenol compounds further find use for increasing and or maintaining intracellular glutathione (GSH) levels. The polyphenol compounds are also useful for treating, preventing, mitigating and/or delaying neurodegenerative conditions, including diabetes, Parkinson's disease, Huntington's disease, Alzheimer's disease, non-Alzheimer's dementias, multiple sclerosis, traumatic brain injury, spinal cord injury or ALS.

US Patent:

20140186329, Jul 3, 2014

Filed:

Feb 6, 2014

Appl. No.:

14/174222

Inventors:

Paul A. Lapchak - San Diego CA, US
David R. Schubert - La Jolla CA, US
Pamela A. Maher - La Jolla CA, US
Chandramouli Chiruta - San Diego CA, US

International Classification:

C07D 311/30
C07D 311/92
C07C 49/835
C07D 295/116
A61K 31/4025
A61K 31/352
A61K 31/47
A61K 31/12
A61K 31/402
C07D 215/233
A61K 45/06

US Classification:

424 9464, 514456, 514312, 514455, 514422, 514685, 514682, 514429

Abstract:

The present invention provides methods of use of polyphenol compounds for treating, preventing, mitigating and delaying ischemia or a condition where ischemia occurs. In one embodiment, the method comprises providing a polyphenol analog; and administering the polyphenol analog to a subject to treat ischemia or a condition where ischemia occurs. Various embodiments of the present invention are useful for the treatment of patients having, or at risk for, any of (1) ischemic stroke, (2) hemorrhagic stroke, (3) cardiovascular disease, (4) ischemia related spinal cord injury, (5) ischemia in diabetic patients, or (6) embolic stroke. For example, use of the polyphenol compounds can maintain glutathione levels in the patient.

US Patent:

20140142172, May 22, 2014

Filed:

May 18, 2012

Appl. No.:

14/118187

Inventors:

Gregory M. Cole - Santa Monica CA, US
Sally A. Frautschy - Santa Monica CA, US
David R. Schubert - La Jolla CA, US
Pamela A. Maher - La Jolla CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
DEPARTMENT OF VETERANS AFFAIRS - Washington DC
SALK INSTITUTE FOR BIOLOGICAL STUDIES - La Jolla CA

International Classification:

A61K 31/353
A61K 31/202

US Classification:

514456

Abstract:

Nutraceutical formulations that improve cognitive function in adults diagnosed with neurodegenerative disease are provided, which comprise a combination of fisetin and DHA.