Pamela S Nuccitelli

US Patent:

8597187, Dec 3, 2013

Filed:

Jun 15, 2009

Appl. No.:

12/484971

Inventors:

Richard Lee Nuccitelli - Millbrae CA, US
Pamela Nuccitelli - Millbrae CA, US
Suman Narsing - Herndon VA, US
Brian Athos - Pleasanton CA, US
Saleh Sheikh - Hampton VA, US

Assignee:

BioElectroMed Corp. - Burlingame CA

International Classification:

A61B 5/103

US Classification:

600306, 600300

Abstract:

The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface.

US Patent:

20090281411, Nov 12, 2009

Filed:

May 8, 2008

Appl. No.:

12/117598

Inventors:

Richard Nuccitelli - Millbrae CA, US
Pamela Nuccitelli - Millbrae CA, US
Uwe F. Pliquett - Heilbad Heiligenstadt, DE
Changyi Li - Laurel MD, US
Suman Narsing - Herndon VA, US
Brian Athos - Pleasanton CA, US
Saleh Sheikh - Hampton VA, US

Assignee:

BioElectroMed Corp. - Burlingame CA

International Classification:

A61B 5/05

US Classification:

600407

Abstract:

The present invention provides a hand-held, noninvasive diagnostic device for measuring the electric fields in mammalian skin and other epithelial structures. The device includes an outer housing that contacts the skin, providing stability and allowing the device to move along with minor movement of the skin. Recessed within the outer housing is a probe that acts as a sensor to measure the electric field in the skin through an aperture in the bottom surface of the outer housing. By applying a series of known voltages while the probe is vibrating, the skin's local surface potential can be measured and the lateral electric field can be calculated from the spatial distribution of surface potential measurements. Active feedback is used to maintain a constant distance between the probe and the skin surface.

US Patent:

20100240995, Sep 23, 2010

Filed:

Mar 17, 2010

Appl. No.:

12/726037

Inventors:

Richard Lee NUCCITELLI - Millbrae CA, US
Pamela NUCCITELLI - Millbrae CA, US
Saleh SHEIKH - Hampton VA, US
Kevin Tran - San Jose CA, US
Brian Athos - Pleasanton CA, US
Mark Kreis - San Francisco CA, US

Assignee:

BIOELECTROMED CORP. - Burlingame CA

International Classification:

A61B 18/14
A61B 8/00

US Classification:

600439, 606 41

Abstract:

Systems and methods for treating tumors on or within internal organs of mammals that have been imaged with endoscopic ultrasound are described. The system uses an expandable bipolar electrode assembly that can be imaged by ultrasound and can penetrate, e.g., the stomach, intestine or bowel wall, etc. and be positioned in or around the tumor on an internal organ while being guided by an operator who visualizes its position with ultrasound imaging. It utilizes an electrode assembly that extends down an internal cavity in the endoscope to allow the operator to spread the electrodes for pulse delivery of a nanosecond pulsed electric field (nsPEF) to the tumor.

US Patent:

20100318082, Dec 16, 2010

Filed:

Mar 11, 2010

Appl. No.:

12/722441

Inventors:

Richard Lee NUCCITELLI - Millbrae CA, US
Pamela NUCCITELLI - Millbrae CA, US
Saleh SHEIKH - Hampton VA, US
Kevin TRAN - San Jose CA, US
Brian Athos - Pleasanton CA, US
Mark KREIS - San Francisco CA, US

Assignee:

BIOELECTROMED CORP. - Burlingame CA

International Classification:

A61B 18/04

US Classification:

606 41

Abstract:

Nanosecond pulsed electric field (nsPEF) parameters for destroying tumors with a single treatment are described. A nsPEF generator may be used with an electrode assembly to apply the pulses to one or more tumors where the parameters for the nsPEF are optimized for treating such tumors.

US Patent:

20110009929, Jan 13, 2011

Filed:

May 9, 2008

Appl. No.:

12/599259

Inventors:

Richard L. Nuccitelli - Burlingame CA, US
Uwe F. Pliquett - Heilbad Heiligenstadt, DE
Pamela Nuccitelli - Burlingame CA, US
Changyi Li - Norfolk VA, US
Saleh H. Sheikh - Norfolk VA, US

International Classification:

A61N 1/04

US Classification:

607 72, 607 2

Abstract:

A medical instrument for delivering electrotherapy is provided. The instrument includes an outer support member having an open distal end and a base wall portion within the support member arranged to form a cup-like volume at the distal end. The instrument also includes at least one aperture formed in the cup-like volume for applying a suction to the cup-like region. The instrument further includes a first and a second electrode having at least a portion within the cup region or proximate to the cup region for providing an electric field in the cup region when a bias signal is applied between the first and second electrodes.

US Patent:

20200315687, Oct 8, 2020

Filed:

Jun 23, 2020

Appl. No.:

16/909948

Inventors:

- Hayward CA, US
Pamela S. Nuccitelli - Millbrae CA, US
Joanne Lum - San Francisco CA, US
Kaying Lui - Millbrae CA, US
Brian G. Athos - San Francisco CA, US
Mark P. Kreis - San Francisco CA, US
Zachary R. Mallon - San Francisco CA, US
Jon Berridge - Oakland CA, US

Assignee:

Pulse Biosciences, Inc. - Hayward CA

International Classification:

A61B 18/14
C12N 13/00
A61N 1/05
A61N 1/32
A61K 39/395
A61K 31/704
A61K 35/13
C07K 16/28
C12N 5/09
G01N 33/574
A61N 1/00

Abstract:

Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on a size and type of the tumor to stimulate an immune response against the tumor and other tumors in the subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.

US Patent:

20190350971, Nov 21, 2019

Filed:

Jul 11, 2019

Appl. No.:

16/509281

Inventors:

- Hayward CA, US
Pamela S. Nuccitelli - Millbrae CA, US
Joanne Lum - San Francisco CA, US
Kaying Lui - Millbrae CA, US
Brian G. Athos - San Francisco CA, US
Mark P. Kreis - San Francisco CA, US
Zachary R. Mallon - San Francisco CA, US
Jon Berridge - Oakland CA, US

Assignee:

Pulse Biosciences, Inc. - Hayward CA

International Classification:

A61K 35/13
C12N 13/00
A61K 31/704
A61B 18/14
A61N 1/32
C07K 16/28
A61K 39/395
G01N 33/574
C12N 5/09
A61N 1/36
A61N 1/05
A61N 1/00

Abstract:

Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on a size and type of the tumor to stimulate an immune response against the tumor and other tumors in the subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.

US Patent:

20190239949, Aug 8, 2019

Filed:

Apr 15, 2019

Appl. No.:

16/384676

Inventors:

- Hayward CA, US
Jon Casey Berridge - Oakland CA, US
Zachary Mallon - San Francisco CA, US
Mark Kreis - San Francisco CA, US
Brian Athos - San Francisco CA, US
Pamela Nuccitelli - Millbrae CA, US

Assignee:

Pulse Biosciences, Inc. - Hayward CA

International Classification:

A61B 18/14
A61B 1/05
A61N 1/32
A61N 1/40
A61B 90/00
A61B 34/20
A61B 1/04
A61B 1/00

Abstract:

Techniques for treating a tumor and vaccinating against cancer are described. The techniques include treating the tumor by positioning electrodes over an interface between the tumor and non-tumor tissue and applying sub-microsecond pulsed electric fields. The positioning is facilitated by an imaginary contour line of a threshold value of the electric field. In an example, the imaginary contour line is overlaid over images that include the tumor such that the electrodes are properly positioned over the tumor. The techniques also include vaccinating against cancer by passing sub-microsecond pulsed electric fields through tumor cells of a subject sufficient to cause the tumor cells to express calreticulin on surface membranes. The tumor cells are extracted and introduced with the expressed calreticulin into the subject or another subject, thereby providing a vaccination.