Pamela D Pierce

US Patent:

6413961, Jul 2, 2002

Filed:

Sep 1, 1999

Appl. No.:

09/388837

Inventors:

Gregory A. Demopulos - Mercer Island WA
Pamela Anne Pierce - San Francisco CA
Jeffrey M. Herz - Mill Creek WA

Assignee:

Omeros Medical Systems, Inc. - Seattle WA

International Classification:

A61K 31535

US Classification:

5142392, 514304, 514311, 514330, 514535, 514537, 514619, 514626

Abstract:

A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general surgical, therapeutic and diagnostic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents, including at least one local anesthetic agent, and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringers solution. Specific preferred embodiments of the solution of the present invention for use in cardiovascular and general vascular procedures also include anti-restenosis agents.

US Patent:

6420432, Jul 16, 2002

Filed:

Apr 17, 2001

Appl. No.:

09/837141

Inventors:

Gregory A. Demopulos - Mercer Island WA
Pamela A. Pierce - Tiburon CA
Jeffrey M. Herz - Mill Creek WA

Assignee:

Omeros Corporation - Seattle WA

International Classification:

A61K 31135

US Classification:

514654, 514415, 514619

Abstract:

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringers solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin antagonist, a serotonin antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin antagonist, a neurokinin antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin antagonist, a bradykinin antagonist and a -opioid agonist.

US Patent:

6645168, Nov 11, 2003

Filed:

Jul 12, 2002

Appl. No.:

10/195625

Inventors:

Gregory A. Demopulos - Mercer Island WA
Pamela A. Pierce - Tiburon CA
Jeffrey M. Herz - Mill Creek WA

Assignee:

Omeros Corporation - Seattle WA

International Classification:

A61M 3100

US Classification:

604 49, 604500, 514654

Abstract:

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringers solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin antagonist, a serotonin antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin antagonist, a neurokinin antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin antagonist, a bradykinin antagonist and a -opioid agonist.

US Patent:

20030105126, Jun 5, 2003

Filed:

Jun 25, 2002

Appl. No.:

10/180815

Inventors:

Gregory Demopulos - Mercer Island WA, US
Pamela Pierce - San Francisco CA, US
Jeffrey Herz - Mill Creek WA, US

Assignee:

Omeros Medical Systems, Inc.

International Classification:

A61K031/46
A61K031/24

US Classification:

514/304000, 514/535000

Abstract:

A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general surgical, therapeutic and diagnostic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents, including at least one local anesthetic agent, and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. Specific preferred embodiments of the solution of the present invention for use in cardiovascular and general vascular procedures also include anti-restenosis agents.

US Patent:

20080167388, Jul 10, 2008

Filed:

Dec 14, 2007

Appl. No.:

12/002227

Inventors:

Gregory A. Demopulos - Mercer Island WA, US
Pamela A. Pierce - San Francisco CA, US
Jeffrey M. Herz - Mill Creek WA, US

International Classification:

A61K 35/00
A61P 29/00
A61P 9/00

US Classification:

514789

Abstract:

A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general vascular therapeutic and diagnostic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. Specific preferred embodiments of the solution of the present invention for use in cardiovascular and general vascular procedures also include anti-restenosis agents. The solution is introduced luminally to continuously irrigate an arterial site during an operative/interventional or diagnostic procedure for preemptive inhibition of pain and inflammation, vascular and non-vascular smooth muscle spasm, and restenosis while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain, inflammation, vasospasm and restenosis includes a serotoninantagonist, a cyclooxygenase inhibitor, an endothelin antagonist, an ATP-sensitive K channel antagonist, a Ca channel antagonist, a nitric oxide donor, an anti-thrombin agent, a glycoprotein IIb/IIIa receptor blocker, a PKC inhibitor and a protein tyrosine kinase inhibitor.

US Patent:

20100029712, Feb 4, 2010

Filed:

Jan 21, 2009

Appl. No.:

12/321488

Inventors:

Gregory A. Demopulos - Mercer Island WA, US
Pamela Anne Pierce - San Francisco CA, US
Jeffrey M. Herz - Mill Creek WA, US

International Classification:

A61K 31/4418
A61K 31/245
A61K 31/164
A61K 31/445
A61P 25/00

US Classification:

514305, 514535, 514626, 514331

Abstract:

A method and solution for perioperatively inhibiting a variety of pain, inflammation, spasm and restenosis processes resulting from cardiovascular or general surgical, therapeutic and diagnostic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents, including at least one local anesthetic agent, and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. Specific preferred embodiments of the solution of the present invention for use in cardiovascular and general vascular procedures also include anti-restenosis agents.

US Patent:

62424475, Jun 5, 2001

Filed:

May 4, 1998

Appl. No.:

9/072843

Inventors:

Gregory A. Demopulos - Mercer Island WA
Pamela A. Pierce - Tiburon CA
Jeffrey M. Herz - Mill Creek WA

Assignee:

Omeros Medical Systems, Inc. - Seattle WA

International Classification:

A61K 3150
A61K 31495
A61K 3144
A61K 31405

US Classification:

514250

Abstract:

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin. sub. 2 antagonist, a serotonin. sub. 3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin. sub.

US Patent:

62612794, Jul 17, 2001

Filed:

May 4, 1998

Appl. No.:

9/072913

Inventors:

Gregory A. Demopulos - Mercer Island WA
Pamela A. Pierce - Tiburon CA
Jeffrey M. Herz - Mill Creek WA

Assignee:

Omeros Medical Systems, Inc. - Seattle WA

International Classification:

A61M 3100

US Classification:

604500

Abstract:

A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin. sub. 2 antagonist, a serotonin. sub. 3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin. sub.