Paola P Grandi

age ~52

from Cambridge, MA

Paola Grandi Phones & Addresses

  • Cambridge, MA
  • 729 Copeland St, Pittsburgh, PA 15232
  • 369 Hanover St, Boston, MA 02113
  • 5220 5Th Ave, Pittsburgh, PA 15232

Resumes

Paola Grandi Photo 1

Assistant Professor

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Location:
Pittsburgh, PA
Industry:
Higher Education
Work:
Nature Publishing Group Jan 2005 - Mar 2009
Editor Assistant, Gene Therapy

University of Pittsburgh Jan 2005 - Mar 2009
Assistant Professor

Massachusetts General Hospital Apr 2001 - Dec 2004
Post-Doc
Skills:
Research
Stem Cell Research
Paola Grandi Photo 2

Chief Strategy Officer

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Location:
Cambridge, MA
Industry:
Biotechnology
Work:
Cold Genesys
Chief Strategy Officer

Revitope
Consultant

Oncorus Jan 2017 - Jan 2018
Director Immunology and Virology

Oncorus Jan 2016 - Jan 2018
Scientific Founder Oncorus

University of Pittsburgh School of Medicine Apr 2005 - Dec 2016
Assistant Professor and Reseach Associate, Neurological Surgery and Molecular Genetics and Biochemistry
Education:
Harvard Medical School
Università Degli Studi Di Ferrara
Doctorates, Doctor of Philosophy, Biochemistry, Philosophy
Università Degli Studi Di Ferrara
Master of Science, Masters, Genetics
Babson College
Master of Business Administration, Masters
Skills:
Tumor Immunology
Oncolytic Vectors
Strategic Planning
Cell Biology
Research
Cross Functional Team Leadership
Managing Partner Relationships
Clinical Research
Pre Clinical Studies
Immunology
Cancer Immunotherapy
Viral Vectors
Drug Discovery
Clinical Study Design
Collaborative R&D
Infectious Diseases
Molecular Pharmacology
Safety Pharmacology
Cell Lines
Mirna
Immunocytochemistry
Animal Models
Virology
Molecular Virology
Molecular Genetics
Molecular Biology
Product Validation
Cell Culture Development
Stem Cells
Data Analysis
Cancer
Cancer Biology
Biotechnology
In Vivo
Cancer Research
Oncology
Biochemistry
Strategy
Life Sciences
Biomarkers
Clinical Development
Business Strategy
Strategic Communications
Interpersonal Skills
Initiation
Paola Grandi Photo 3

Responsabile Marketing Strategico

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Industry:
Financial Services
Work:
Linea S.p.A.
Responsabile Marketing Strategico

Us Patents

  • Oncolytic Hsv Vector

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  • US Patent:
    20190262410, Aug 29, 2019
  • Filed:
    Nov 14, 2018
  • Appl. No.:
    16/191141
  • Inventors:
    - Pittsburgh PA, US
    Justus B. Cohen - Allison Park PA, US
    Paola Grandi - Pittsburgh PA, US
  • Assignee:
    University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
  • International Classification:
    A61K 35/763
    C07K 14/005
    C12N 7/00
  • Abstract:
    The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more microRNA target sequences inserted into a locus of an HSV gene required for HSV replication, wherein said target sequence is the reverse complement of microRNA miR-124 and wherein said target sequence is present in the ICP4 gene, and (c) a transgene encoding a matrix metalloproteinase. The present invention also provides a method of killing a cancerous cell using a recombinant HSV according to the invention and a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a recombinant HSV according to the invention.
  • Oncolytic Hsv Vector

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  • US Patent:
    20170274025, Sep 28, 2017
  • Filed:
    Jun 7, 2017
  • Appl. No.:
    15/616585
  • Inventors:
    - Pittsburgh PA, US
    Justus B. Cohen - Allison Park PA, US
    Paola Grandi - Pittsburgh PA, US
  • International Classification:
    A61K 35/763
    C07K 14/005
    C12N 7/00
  • Abstract:
    The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more microRNA target sequences inserted into a locus of an HSV gene required for HSV replication, wherein said target sequence is the reverse complement of microRNA miR-124 and wherein said target sequence is present in the ICP4 gene, and (c) a transgene encoding a matrix metalloproteinase. The present invention also provides a method of killing a cancerous cell using a recombinant HSV according to the invention and a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a recombinant HSV according to the invention.
  • Oncolytic Hsv Vector

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  • US Patent:
    20170035819, Feb 9, 2017
  • Filed:
    Jul 7, 2016
  • Appl. No.:
    15/204350
  • Inventors:
    - Pittsburgh PA, US
    Justus B. Cohen - Allison Park PA, US
    Paola Grandi - Pittsburgh PA, US
  • International Classification:
    A61K 35/763
    C12N 7/00
  • Abstract:
    The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.
  • Oncolytic Hsv Vector

    view source
  • US Patent:
    20160250267, Sep 1, 2016
  • Filed:
    Oct 28, 2014
  • Appl. No.:
    15/032958
  • Inventors:
    - Pittsburgh PA, US
    Justus B. COHEN - Allison Park PA, US
    Paola GRANDI - Pittsburgh PA, US
  • International Classification:
    A61K 35/763
    C12N 7/00
  • Abstract:
    The present invention provides a recombinant oncolytic Herpes Simplex Virus (oHSV) comprising a non-HSV ligand specific for a molecule (protein, lipid, or carbohydrate determinant) present on the surface of a cell (such as a cancer cell) and one or more copies of one or more microRNA target sequences inserted into one or more HSV gene loci, preferably one or more HSV gene(s) required for replication of HSV in normal (i.e., non-cancerous) cells. The invention further provides stocks and pharmaceutical compositions comprising the inventive oHSV and methods for killing tumor cells employing the inventive oHSV.

Googleplus

Paola Grandi Photo 4

Paola Grandi

Work:
COMMERCIALISTA
About:
ODIO L'IPOCRISIA
Tagline:
VIVI E LASCIA VIVERE
Bragging Rights:
ARRIVARE A FINE MESE
Paola Grandi Photo 5

Paola Grandi

Work:
Atelier "Orto della Vecchia Strega" - Titolare unico
Paola Grandi Photo 6

Paola Grandi

Paola Grandi Photo 7

Paola Grandi

Paola Grandi Photo 8

Paola Grandi

Paola Grandi Photo 9

Paola Grandi

Paola Grandi Photo 10

Paola Grandi

Work:
University of Pittsburgh Medical Center
Education:
University of Ferrara
Relationship:
Married

Youtube

Stairbook - Chapter 5 - La maschera della gra...

Sandro Gros-Pietro intervista Paola Grandi, autrice del libro "La masc...

  • Duration:
    19m 14s

PAOLA CORTELLESI a casa dei Me contro Te

*SEGUICI SU INSTAGRAM!* ME CONTRO TE (@mecontrote) SOF (@sofi.scali...

  • Duration:
    2m 37s

Gianna Nannini, Emma & Irene Grandi - I Masch...

Il progetto nato da un'ideadiLoredan... Bert (in occasione dei suoi ...

  • Duration:
    4m 18s

Paola Giovetti: "Assagioli e i grandi iniziat...

Conferenza tenutasi a Conegliano, il 10 ottobre 2015, a cura dell'Isti...

  • Duration:
    1h 26s

Nonna paola..

Nonna talking about the old days ..

  • Duration:
    3m 50s

Aeroccino 4 Nespresso

  • Duration:
    1m 9s

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