Parag R Chitnis

US Patent:

20180326097, Nov 15, 2018

Filed:

Jul 10, 2018

Appl. No.:

16/031094

Inventors:

- Arlington VA, US
Michael H. Stewart - Springfield VA, US
Okhil Nag - Alexandria VA, US
Jeffrey R. Deschamps - Laurel MD, US
Kimihiro Susumu - Alexandria VA, US
Eunkeu Oh - Alexandria VA, US
Lauren D. Field - College Park MD, US
Alexander L. Efros - Annandale VA, US
Alan L. Huston - Aldie VA, US
Igor L. Medintz - Springfield VA, US
Philip E. Dawson - San Diego CA, US
Nashaat Rasheed - Fairfax VA, US
Parag V. Chitnis - Fairfax VA, US
John R. Cressman - Fairfax VA, US

International Classification:

A61K 49/22
G01N 33/58

Abstract:

A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be Cfullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.

US Patent:

20180113205, Apr 26, 2018

Filed:

Oct 25, 2017

Appl. No.:

15/793969

Inventors:

- Fairfax VA, US
Parag Chitnis - Fairfax VA, US
Nima Akhlaghi - Sterling VA, US
Elizabeth Tarbox - Nokesville VA, US
Paul Otto - Lorton VA, US
Paul Gammell - Exmore VA, US

International Classification:

G01S 7/52
G01N 29/06
G01N 29/26
G01S 15/89
A61B 8/00

Abstract:

Methods, systems, and apparatuses are disclosed for ultrasound imaging comprising Time Delay Spectrometry. A frequency swept signal can be transmitted through a medium, such as human tissue. The signal can be a low-voltage signal (e.g., 0 volts to 5 volts peak-to-peak) transmitted for long duration (e.g., 20 milliseconds) at various frequencies. As the signal propagates through the medium it can be reflected and delayed. A delay associated with the signal the can cause a change in the associated frequencies. The signal can be filtered to retain only frequencies in an audio frequency range. The signal can be beamformed and processed to produce an image.